Wednesday, 09 October 2019 17:14

The Centro Nacional de Biotecnología (CNB-CSIC) will host the 27th edition of the traditional conference “Advances in Molecular Biology by Young Researchers Abroad” next 19th of December 2019.

Tuesday, 08 October 2019 09:14
  • Investigadoras del CNB identifican mecanismos que generan conexiones inesperadas ante alteraciones en el desarrollo del individuo.
  • Las neuronas de la corteza tienen la capacidad de generar circuitos alternativos con nuevas funciones optimizadas ante situaciones adversas o carencias de estímulos
  • El trabajo aporta una nueva perspectiva para comprender la diversidad de circuitos y comportamientos, un factor muy importante para el manejo y el tratamiento de síndromes como el espectro autista.
Tuesday, 17 September 2019 12:33
  • La infección por la bacteria E. coli enterohemorrágica (EHEC) se transmite por alimentos contaminados produciendo colitis hemorrágicas, anemia hemolítica e insuficiencia renal, lo que puede llegar a causar graves secuelas y la muerte.
  • No existe en la actualidad vacuna o una terapia eficiente, pero investigadores del CSIC han encontrado una novedosa estrategia que puede bloquear la infección.

La bacteria E. coli enterohemorrágica (EHEC) se encuentra a menudo presente en el intestino del ganado bovino sin causar síntomas, pero desde estos animales puede llegar a contaminar alimentos (p.ej. carne picada, vegetales, zumos) si no se toman las medidas sanitarias adecuadas durante su elaboración. Tras la ingestión de alimentos contaminados EHEC infecta el colon humano y produce toxinas que causan colitis hemorrágica, anemia hemolítica e insuficiencia renal, lo que puede generar graves efectos secundarios e incluso la muerte. Estas infecciones suponen un riesgo para la salud pública ya que no existe vacuna ni una terapia efectiva frente a EHEC, ya que el uso de antibióticos puede inducir una mayor liberación de toxinas.

Monday, 16 September 2019 15:21

The new annual cycle of Seminars will start next Friday 20th of September with the inaugural talk from Patricia Fara, director at the History and Philosophy of Science Department at Clare College, University of Cambridge.

Seminars will take place Friday at 12:00 in the Main Lecture hall of the institute

SeminariosSenior2019 20WEB

 

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Tuesday, 10 September 2019 13:55

Ayer se celebró en Madrid la entrega de las acreditaciones Severo Ochoa y María de Maeztu. Pedro Duque, ministro en funciones de Ciencia, Innovación y Universidades entregó las distinciones a los centros y unidades elegidos, que destacan por su alta competitividad, sus ambiciosos planes estratégicos, una producción científica de máxima calidad y una gran capacidad para atraer talento nacional e internacional.  

Para el CNB, esta es la segunda acreditación Severo Ochoa tras la recibida en el año 2013. Fernando Rojo, director del centro, destacó en la ceremonia como la acreditación Severo Ochoa ha supuesto un cambio importante para el CNB, promoviendo la realización de un plan estratégico del centro a medio y largo plazo donde se han identificado las fortalezas del centro de cara a garantizar la calidad, excelencia y el impacto de nuestra investigación en el futuro.

Friday, 06 September 2019 13:45

- El equipo de Vicente Rubio  ha identificado un mecanismo por el cual las plantas regulan de manera precisa la respuesta a las variaciones en la disponibilidad del agua.

Los estomas son unos pequeños poros que se encuentran en las hojas y los tallos de las plantas, a través de los cuales se realiza el intercambio gaseoso. Sin embargo, también son la vía por la se pierde el agua a través de la  transpiración. En condiciones de sequía, las plantas cierran los estomas mediante un proceso que está controlado por el ácido abscísico (ABA), una hormona vegetal que se sintetiza cuando la planta detecta la falta de agua.

En el artículo del Dr. Vicente Rubio, publicado en The Plant Cell,  han identificado una factor de Arabidopsis, ALIX, una proteína de membrana que interacciona con los receptores de ABA y regula su tráfico y posterior degradación en la vacuola.

Wednesday, 04 September 2019 17:17
  • Las proteínas IFI44 e IFI44L favorecen la replicación de virus como el de la gripe y coronavirus, causantes de enfermedades respiratorias y también arenavirus, que pueden causar fiebres hemorrágicas graves
  • Los resultados, fruto de dos estudios del CNB, abren nuevas vías para controlar infecciones virales y tratar enfermedades asociadas a procesos de inmunidad innata exacerbados

Un equipo de investigadores del Consejo Superior de Investigaciones Científicas (CSIC), en colaboración con investigadores de la Universidad de Rochester, EEUU, ha identificado dos proteínas que favorecen las infecciones virales al inhibir la respuesta inmune innata. Los resultados de dos estudios, que se publican en las revistas mBio y Journal of Virology, muestran que las proteínas IFI44 e IFI44L favorecen la replicación de diferentes tipos de virus, como el de la gripe o coronavirus, causantes de enfermedades respiratorias que pueden llegar a ser graves, o arenavirus, que pueden causar fiebres hemorrágicas severas. Estos trabajos abren nuevas vías para controlar infecciones virales y para tratar enfermedades asociadas a procesos de inmunidad innata exacerbados.

Tuesday, 20 August 2019 13:30
  • This study identifies the opening and closing mechanism for T7 portal protein during the viral DNA translocation process
  • Researchers have used a combination of cryo electron microscopy and crystallography techniques to study this virus

Nature Communications publishes the result of the collaboration between several research groups belonging to the Spanish Council for Scientific Research (CSIC) on the structure and function of the bacteriophage T7 portal protein. Experts in cryo electron microscopy of the National Center for Biotechnology (CSIC), directed by José L. Carrascosa, and in X-ray crystallography of the Institute of Molecular Biology of Barcelona (CSIC), the Institute of Biomedical Research (IRB Barcelona), and the Center Biological Research (CSIC), directed by Miquel Coll, have worked together to combine both techniques, obtaining new data on the mechanism of action of this protein in the process of viral maturation.

Friday, 16 August 2019 14:43
  • Un estudio halla dos tipos de bacterias de la misma especie que habita en lagos adaptadas a aguas frías y aguas calientes, respectivamente
  • Las diferencias entre individuos favorecen la supervivencia de la especie a largo plazo

Un nuevo estudio con participación de investigadores del Consejo Superior de Investigaciones Científicas (CSIC) ha demostrado que las especies bacterianas con mayor diversidad son más capaces de sobrevivir; es decir, tienen una mayor capacidad de estar presentes en diferentes situaciones ambientales y una menor variabilidad ante cambios en las condiciones ambientales de su hábitat. Los resultados del trabajo se publican en la revista The ISME Journal.

El estudio, realizado por investigadores del Centro Nacional de Biotecnología (CNB) en colaboración con la Universidad de Wisconsin-Madison (Estados Unidos), analiza cómo afecta la microdiversidad (el conjunto de individuos de la misma especie que presentan diferencias en las funciones que desempeñan o en las condiciones óptimas en las que viven) a la estabilidad de las especies bacterianas de la comunidad microbiana y, por tanto, al ecosistema.

Monday, 05 August 2019 16:09

The production of interferon in infected cells is one of the first and most important lines of defense against infections caused by viruses and bacteria. It triggers a response that includes changes in gene expression to produce specific proteins capable of controlling and preventing the spread of the infection.

Multiple genes are involved in the control of the cellular response to interferon. Recently, the group of Hugh Reyburn, researcher at the National Center for Biotechnology (CSIC) has published data demonstrating that the IRF9 protein plays a key role in the control of the response to infection mediated by interferons, in collaboration with researchers from the Research Center Biological (CSIC), Hospital La Paz and the Central University of Venezuela.

Friday, 02 August 2019 14:37
  • 15 research centers of excellence including the CNB will host African scientists from January 2020

Science by Women programme promotes African women’s leadership in scientific research and technology transfer and to foster the capacity of the research centres in their home countries. The programme´s ultimate goal is to enable African women researchers to play a leading role in the transition of Africa to a knowledge-based and innovation-led economy through research in health, agriculture and food security, water, energy and climate change, as well as mathematics and economic science that can be transferred into products, processes, services and technologies having impact on people´s lives.

Researchers interested in applying for a stay at the National Biotechnology Center should contact the research groups of their interest beforehand to obtain an acceptance letter that needs to be attached in their application

More information about the program and the submission of applications on the program website

Thursday, 01 August 2019 17:26

Tras el fallecimiento de nuestro compañero Carlos Enríquez, desde el CNB expresamos nuestro dolor por su pérdida  y mandamos un fuerte abrazo a su familia.

Le recordamos con las emotivas palabras de Lluís Montoliu

Un centro de investigación es una pequeña ciudad. Una colectividad en la que convive mucha gente, que va sucediéndose a lo largo de los años, cada cual realizando su función, para que todo el engranaje siga rodando perfectamente. En un centro coinciden los investigadores, de diversos tipos (en formación, postdoctorales, visitantes, responsables de grupo), el personal administrativo y de servicios (limpieza, seguridad, cafetería, etc…) y por supuesto el personal técnico y de apoyo a los laboratorios, quienes contribuyen con su trabajo a la adecuada ejecución de los proyectos de investigación. Muchas veces se trata de personas transparentes. Frecuentemente no reparamos en su trabajo, aunque su labor sea fundamental. Su presencia es esencial para que todo funcione correctamente, para que las logísticas y las rutinas departamentales sigan operativas sin que nadie se percate. Para que los reactivos y soluciones estén en el cajón o el estante donde esperamos encontrarlas. Siempre listas. Siempre a punto.

Carlos Enríquez era uno de estos técnicos de nuestro centro. Probablemente estaba entre quienes llevamos más años conviviendo en el CNB, más de 25 años en su caso. Había pasado por diversos laboratorios y por diversos servicios. Ahora llevaba ya muchos años de técnico de nuestro departamento de biología molecular y celular, encargado de la preparación y facturación de los medios y soluciones para cultivos celulares de los laboratorios de la primera planta del CNB. Su personalidad extrovertida y su irrefrenable gusto por la conversación espontánea, a todas horas, hacía inevitable que cualquiera de los habitantes del centro no le conociera. Todos recordamos en algún momento haber escuchado sus historias, sus aficiones, sus achaques, sus chistes. Reconozco que, en más de una ocasión, sin tiempo para detenerme a conversar, le había dado una palmadita en la espalda, tras saludarlo, emplazándole a otro momento para hablar. Y su respuesta era siempre una sonrisa, con la que te reconfortaba la mala conciencia que te quedaba por no haber podido detenerte a charlar con él.

Carlos Enríquez estaba cuando se le necesitaba. Nos había hecho favores a todos. Recordaba detalles personales de cada uno de nosotros, de dónde éramos, nuestras familias, nuestras vacaciones, etc… Por supuesto, a raíz de su afición por la fotografía muchos recordaremos las fotos de grupo que nos tomó, fuera y dentro del CNB. O para echarnos una mano en cualquier remodelación de los laboratorios. Estaba presente en las fiestas, en las actividades sociales y culturales, en el grupo de teatro, en la coral del campus, y en muchos otros grupos espontáneos que se formaron en el centro a lo largo de todos estos años.

Tampoco olvidaba sus orígenes en el CBMSO, donde coincidió con Antonio Varas y Luis Yuste, que también se trasladaron al CNB, abordando la secuenciación del genoma del virus de la peste porcina, bajo la supervisión de Paco Rodríguez, en el laboratorio de Eladio Viñuela. Seguía cultivando la amistad con sus ex-compañeros del CBMSO mediante visitas o comidas periódicas.

Todo ello terminó abruptamente el pasado lunes, 29 de julio, de forma inexplicable. Esta pequeña ciudad que es el CNB perdió uno de sus habitantes. Carlos Enríquez ya no está en el centro, pero su huella y su recuerdo persistirán.

Thursday, 01 August 2019 16:45

Cancer immunotherapy has become an effective strategy of the antioncological arsenal, but it only works in certain types of cancer and in a limited number of patients. Although the immune system can recognise and eliminate tumor cells, tumors have evasion mechanisms to prevent it. One of them is the expression of PD-L1 protein on the surface of tumors, which blocks the antitumor capacity of cytotoxic CD8 lymphocytes through mechanisms that are still poorly understood. 

A group of researchers led by Santos Mañes from the National Center for Biotechnology (CNB-CSIC), has identified PD-L1 mechanism to inactivate cytotoxic cells by altering the mitochondria and reprogramming the cell metabolism and publish their results in the Journal for Immunotherapy of Cancer.

Monday, 15 July 2019 13:01
  • El proyecto LIFE LEMNA presenta el primer prototipo semiindustrial de Europa basado en la tecnología de cultivo de lenteja de agua (Lemna) para la recuperación de nutrientes contenidos en los purines excedentarios de porcino.
  • La instalación, de 250 m2, puede producir más de 17t de biomasa/ha·año, con una productividad de proteína de origen vegetal 6-7 veces mayor que la obtenida en el cultivo de soja
  • La lenteja de agua es una pequeña planta acuática menor de un cm, flotante, de forma circular y de color verde hierba intenso, que es capaz de absorber los nutrientes contenidos en los residuos ganaderos de forma muy eficiente y transformarlos en una biomasa rica en proteínas.

El proyecto europeo LIFE LEMNA busca soluciones que reduzcan el impacto medioambiental generado por la acumulación de nutrientes en los purines excedentarios de la ganadería intensiva. Encontrar soluciones ambiental y económicamente viables para estos materiales es una prioridad en España y el resto de la UE debido a la problemática de contaminación por nitratos y emisiones de CO2 asociada. Además, reducir la huella ambiental de los productos cárnicos va a resultar un factor de competitividad en el futuro por lo que el sector necesita encontrar soluciones.

Para ayudar a resolver este problema, el centro tecnológico AINIA, junto con el Centro Nacional de Biotecnología (CNB) perteneciente al Consejo Superior de Investigaciones Científicas (CSIC) y las empresa Porgaporcs y ECOBIOGAS, han desarrollado la primera planta piloto a escala semi industrial de Europa que permite recuperar los nutrientes (nitrógeno, fósforo) de los purines, y reutilizarlos en la propia zona en la que se generan.

Friday, 28 June 2019 17:26
  • Las chaperonas moleculares son clave para el equilibrio entre la síntesis y degradación de las proteínas celulares
  • Para analizar la función de estos complejos y conocer su estructura, los científicos han empleado el criomicroscopio electrónico del Centro Nacional de Biotecnología del CSIC

Un trabajo codirigido por investigadores del Centro Nacional de Biotecnología del Consejo Superior de Investigaciones Científicas (CSIC) ha determinado el mecanismo de funcionamiento del complejo CCT, una de las chaperonas moleculares más importantes en organismos eucariotas. Los científicos, que publican sus resultados en el último número de la revista Nature Communications, han empleado un criomicroscopio electrónico de última generación.

Tuesday, 25 June 2019 10:57

Investigadores del CSIC colaboran en un estudio internacional sobre el origen y la evolución de las variedades europeas de la patata, con la ayuda de las colecciones históricas de los herbarios. La adaptación fuera de su región de origen puede haber seguido rutas similares en Europa y el Sur de América.

Monday, 17 June 2019 16:47

The 2019 annual meeting of the Spanish Society of Virology (SEV) 2019 has been held in June in Barcelona. In this edition, two CNB-CSIC researchers have been awarded with the Society prizes to the Senior Virologist and Young Virologist.

Monday, 17 June 2019 11:02
  • Identificados en ‘Arabidopsis thaliana’ los genes que regulan un nuevo mecanismo de adaptación a altas temperaturas
  • La interacción genética entre dos genes duplicados regula el ciclo de la división celular, según un estudio del CSIC

Las plantas están sometidas a fluctuaciones de temperatura diarias y estacionales que provocan cambios en sus patrones de expresión genética.  Esta plasticidad les permite adaptarse a las condiciones ambientales mediante cambios en su ritmo de crecimiento y tiempo de floración. 

Entender cómo las plantas de diferentes regiones del mundo se adaptan a las temperaturas del ambiente en el que crecen es el objetivo de las investigaciones de un equipo de científicos del Consejo Superior de Investigaciones Científicas (CSIC) en el Centro Nacional de Biotecnología. En su último trabajo, publicado en la revista The Plant Cell, los investigadores han identificado en la planta modelo Arabidopsis thaliana dos genes duplicados, ICARUS1 y 2 (ICA1 e ICA2), que están implicados en la regulación de la respuesta térmica del desarrollo de las plantas.

Thursday, 13 June 2019 13:20
  • El Centro Nacional de Biotecnología (CSIC) y la Universidad Autónoma de Madrid organizan este simposio los días 12 y 13 de junio
  • Una treintena de prestigiosos expertos repasan el estado actual de la criomicroscopía electrónica a través de su experiencia investigadora y la aplicación de la técnica en diferentes campos

Los días 12 y 13 de junio se celebra el simposio 25 años de criomicroscopía electrónica en España. Un homenaje a José L. Carrascosa en el campus de la Universidad Autónoma de Madrid (UAM). Este simposio, enmarcado en la celebración del 50 Aniversario de la UAM, ha sido inaugurado por la presidenta del Consejo Superior de Investigaciones Científicas (CSIC), Rosa Menéndez, y por el rector  de la UAM, Rafael Garesse.

Friday, 07 June 2019 12:34

Carmen Simón, researcher from the Molecualr Plant Genetics Department and director in the CSIC postgraduate Department has received the Prize for Science Dissemination awarded by the Spanish Confederation of Scientific Societies (COSCE) as a recognition of her efforts in science promotion.


The Prize committee remarked her frequent media appearances, books editions and the organisation of public engagement activities for children through the Association "Apadrina la Ciencia", where she is the current president and a founder member.

In addition, the jury highlighted her active search for contributions from individual donors, foundations and companies, which has allowed to promote doctoral theses awards, grants for emerging researchers and one-year contracts for junior researchers to complete doctoral thesis. As an example of her solidarity principles, Carmen Simón has donated the Prize compensation to Apadrina la Ciencia to generate young researchers contracts..

Friday, 07 June 2019 12:09
  • The purpose of this collaboration is the fulfillment of industrial-scientific collaborations in new developments in Imaging Microscopy technology.
  • This industrial-scientific partnership between CNB-CSIC and Leica Microsystems will foster the development of both parties and bring excellence to the joint endeavor.

Thanks to this agreement, the CNB Advanced Light Microscopy facility will continue to provide high-end imaging technology, tailored trainings, users´ support and fulfill best practice requirements, further evolving into the high-quality standard of worldwide recognised biological imaging centers.

This close cooperation will enable CNB and its scientific partners to learn about state-of the-art technologies in advance, whilst industry will benefit from the constant feedback experience by scientific users.

The unparalleled support of Leica Microsystems will contribute to  develop a center of excellence within the Advanced Light Microscopy facility at CNB.

Tuesday, 21 May 2019 15:59

Fernando Almazan, researcher at CNB participates in the project COSMIC that has been awarded 3.5 Million Euro to develop systems to detect CBRNE threats in containers. 

Read the full press release here

Monday, 06 May 2019 16:30

Regeneration of cardiac cells in the adult is very limited, and cardiomyocyte renewal rate is limited to  around 1% per year. In other tissues, the location of stem cells reservoirs is known, but there is no consensus of where they are located in the heart after tissue damage.

Now, the data published in Redox Biology by Antonio Bernad's group describe the location of stem cells in the heart and how they evolve in response to damage and aging.

Monday, 29 April 2019 18:15

La flexibilidad de las chaperonas moleculares, un conjunto de proteínas presentes en todas las células, favorece que actúen en diferentes procesos. Por un lado, ayudan a que otras proteínas recién formadas adopten la estructura tridimensional adecuada para su funcionamiento (plegamiento), pero, por otro, contribuyen a su degradación, un proceso opuesto al anterior, pero también esencial a nivel celular.

Friday, 26 April 2019 18:36

El próximo día 20 de mayo se celebrará el simposium “Biología para el siglo XXI”” en el Centro Nacional de Biotecnología. Este evento de homenaje al profesor de investigación del CNB Carlos Martínez Alonso, contará con la presencia de ponentes de renombre internacional como los investigadores Juan Carlos Izpisua y Felipe Lira entre otros.

Ya está disponible el programa del evento.

Friday, 26 April 2019 17:39

The symposium "25 years of cryoelectron microscopy in Spain: A tribute to José L. Carrascosa” will be held next 12th and 13th of June at the Autonomous University of Madrid. This symposium, included in the celebration of the 50th anniversary of the Autonomous University, will bring internationally recognised speakers such as professors Joachim Frank and Richard Henderson, awarded with the Nobel Prize in Chemistry 2017 for the development of cryoelectron microscopy.

Over two days, the current state of the art will be reviewed through the presentations of more than 30 scientists who use cryoelectron microscopy techniques in their respective research fields. In addition, these days will serve as well-deserved tribute to the CSIC research professor José L. Carrascosa, and essential promoter for the development of cryoelectron microscopy in Spain and specially at the CNB.

Inscription not required,

Full program available here


Monday, 22 April 2019 16:42

The Centro Nacional de Biotecnología (CNB-CSIC) organises this summer the 7th Course on Introduction to Research through the CSIC JAE-Into ICUS program. These scholarships are directed to qualified and highly motivated students willing to pursue a career in science research and who would like to contact the scientists at the CNB. Students must be currently enrolled in the final year of their university degree in science (academic year 2018-2019).

Monday, 15 April 2019 16:04

New Collaboration Scholarships at Centres of Excellence Severo Ochoa and Units of Excellence María de Maeztu CSIC

This call is addressed to students enrolled or registered in an Official Master course during 2019-2020 academic year in the areas of Life Sciences, Health Science, Science, Physics, Computer Science, Biomedical or Agronomic Engineering. Each grant is allocated with 6300 euros paid in nine monthly installments. Applicants must have completed the degree in the academic year 2017/2018 or later and credit an average grade equal to or greater than 8.40.

Tuesday, 09 April 2019 18:37

The call to apply for the Introduction to Research JAE-CSIC scholarships is opened. These scholarships are specially aimed to university students in the last year of their university degree. The duration of the fellowship is for 5 consecutive months, with the option to start either in September or October 2019.

The National Center for Biotechnology offers up to 28 places in this call:

Tuesday, 09 April 2019 15:46

Urtzi Garaigorta, Ramón y Cajal researcher at the National Center for Biotechnology (CSIC) received today the Prize “Apadrina la Ciencia-VWR”. This Reward, that will cover  laboratory material for new researchers is offered by the non-profit Association Apadrina La Ciencia in collaboration with the company VWR.

Tuesday, 09 April 2019 12:40

Dr. Lluis Montoliu has received this week in Japan the 12th ISTT Prize from The International Society for Transgenic Technologies (ISTT). The ISTT Prize is awarded to investigators who have made outstanding contributions to the field of transgenic technologies.  The Award Committee recognised not only his seminal work on YAC transgenesis but also his efforts to develop and establish the ISTT, an organization now counting with more than 700 members worldwide where Dr. Montoliu served as the first President from 2006 to 2014.

Monday, 01 April 2019 16:48

Con el reciente fallecimiento de Rafael Pérez Mellado, el CNB no sólo pierde a un experto en microbiología y bioseguridad sino a uno de los artífices del progreso y desarrollo científico de nuestro centro.

Thursday, 28 March 2019 17:15
  • Un estudio confirma el perfil de resistencias de ambientes clínicos, que aumenta en países del sur de Europa, donde el consumo de antibióticos es mayor que en el norte
  • El análisis de las bacterias presentes en las depuradoras de agua es fundamental en la vigilancia de resistencias a antibióticos presentes en el medio ambiente
  • Este método de análisis podría servir como base para desarrollar sistemas de vigilancia global de la resistencia a los antibióticos
Thursday, 28 March 2019 13:28
  • The results of the study published in eLife help to understand how DNA is organised during cell division in Bacillus subtilis.

During cell division, DNA condensates to assure a proper distribution of the genetic material but the mechanism is not fully understood. An international study led by researchers from the National Centre of Biotechnology (CNB-CSIC) reveals the role of ParB, a protein responsible for chromosome organization of the chromosome during cell division in DNA condensation in Bacillus subtilis.

Monday, 04 March 2019 15:27

Un estudio internacional con participación de investigadores del Consejo Superior de Investigaciones Científicas (CSIC) ha mostrado la estructura del centriolo en sus primeras fases de ensamblaje. Este nuevo estudio, publicado en la revista eLife, arroja nueva luz sobre el conocimiento del centriolo, cuyas mutaciones se sabe que están detrás de diversas enfermedades humanas, como algunos tipos de cáncer.

Wednesday, 20 February 2019 12:19

Un equipo liderado por investigadoras del Consejo Superior de Investigaciones Científicas (CSIC) ha descrito un método para analizar moléculas, que indican la existencia de una patología, en nanovesículas también llamadas vesículas extracelulares (pequeñas partículas liberadas por las células y que se encuentran en los fluidos corporales). El método, publicado en la revista Scientific Reports, permite obtener información sobre estas minúsculas vesículas directamente de muestras de orina y analizar su composición. De esta manera, es fácilmente trasladable a la práctica clínica y tiene como ventaja que no supone procedimientos invasivos para el paciente.

Wednesday, 06 February 2019 16:38

The genomic material needs to be precisely organized and access to its information carefully regulated in order to ensure proper functioning of a cell. These instructions are encoded in the DNA, although not in the form of the well-known three letter words (or codons) that chemically code for proteins. Instead, an increasing number of works are indicating the importance of a physical code, by which the nucleotide sequence can modulate the structure and flexibility of the double-helix. In this work we found a striking connection between DNA sequence, structure and flexibility: the sequence can specifically modify the flexibility by means of concerted changes in the structure of the double-helix.

Wednesday, 06 February 2019 15:15

El próximo 11 de febrero se celebra el Día Internacional de la Mujer y la Niña en la Ciencia

Descubre en el campus de Cantoblanco a científicas premiadas y olvidadas por el Nobel

  • Un escape road presentará perfiles de mujeres galardonadas con el Nobel en un recorrido en el que los visitantes responderán preguntas sobre las investigadoras.
  • Los participantes buscarán, a través de una aplicación móvil, carteles ocultos de grandes científicas que no ganaron el Nobel.
  • Este “escape road” es una actividad conjunta organizada por los centros del CSIC del campus de Cantoblanco: (Instituto de Ciencia de Materiales de Madrid, Instituto de Cerámica y Vidrio, Instituto de Catálisis y Petroquímica, Centro Nacional de Biotecnología, Centro de Biología Molecular, Instituto de Ciencias Matemáticas, Instituto de Física Teórica e Instituto de Investigación en Ciencias de la Alimentación.)
Friday, 01 February 2019 18:42

El Centro Nacional de Biotecnología (CNB) del CSIC, acreditado como centro de excelencia Severo Ochoa, invita a catedráticos y profesores de enseñanza secundaria a participar en la nueva edición del curso presencial de actualización docente La biotecnología ante los retos de la sociedad actual que se impartirá del 5 al 28 de marzo de 2019, en el campus de Cantoblanco, Madrid. El curso ha sido autorizado por la Dirección General de Mejora de la Calidad de la Enseñanza y será impartido por investigadores del CNB con amplia experiencia en comunicación científica.

Este curso multidisciplinar tiene como objetivo contribuir a actualizar la formación de los docentes en Microbiología, Virología, Inmunología, Oncología, Genética Molecular de Plantas y Biología Molecular, Estructural y Celular. Se hablará del vertiginoso progreso del área de la biotecnología y de cómo está contribuyendo al bienestar de los ciudadanos. Contaremos con la participación de investigadores de prestigio internacional y reconocidos comunicadores científicos de nuestro instituto con al intención de contribuir a la formación continua del profesorado y a la difusión de conocimientos sobre un tema de tanta relevancia para nuestra sociedad del siglo XXI.

La inscripción estará abierta hasta el 26 de febrero de 2019 y se realizará a través de la página de formación del profesorado de la Comunidad de Madrid 

El programa del curso está disponible aquí.

Tuesday, 22 January 2019 18:27

Una delegación de CEIM Confederación empresarial Madrid-CEOE ha visitado hoy el Centro Nacional de Biotecnología (CNB-CSIC) en un encuentro organizado por la Fundación General CSIC (FGCSIC), donde han conocido los avances en investigaciones biotecnológicas relacionadas con la biomedicina, la agricultura sostenible y bioremediación ambiental que se están llevando a cabo desde el Consejo Superior de Investigaciones Científicas (CSIC).

Tuesday, 11 December 2018 15:16

Next 21st of December 2018, the Centro Nacional de Biotecnología (CNB-CSIC) will hold the XXVI edition of the traditional workshop Advances in Molecular Biology by Young Researchers Abroad.

During the  day, we will host short talks by young scientist working abroad and a round table: Science and Society: Let´s talk the same language". 

Attendance is free and open to everybody.

 

Monday, 03 December 2018 15:46

Next 17th  and 19th December, we will celebrate the XXVI edition of the CNB Scientific Workshop. These days, CNB scientists from the different departments will explain the current state of their scientific research.

As previous years, the programme includes the participation of selected PhD students from the CNB. Two specific sessions will host the young researchers, with short talks and a poster session to finish the workshop each day.  

Monday, 03 December 2018 13:11

For the fifth consecutive year, Roberto Solano, researcher at Centro Nacional de Biotecnología is the list of the most cited researchers in the Plant &Animal Science area​​ published by Clarivate Analytics.

Tuesday, 06 November 2018 15:36

CNB researcher Lluís Montoliu receives the"SINCronizados" award from the scientific news agency SINC as a recognition of his enthusiam in science communication.


 

Tuesday, 06 November 2018 12:59

El CNB se suma a los centros de investigación europeos que piden la regulación de los organismos editados geneticamente para salvaguardar las técnicas de edición génica en la agricultura sostenible

Wednesday, 24 October 2018 13:11

On 21st of December 2018, the Centro Nacional de Biotecnología of the CSIC (CNB-CSIC) will host the 26th edition of the traditional conference Advances in Molecular Biology by Young Researchers Abroad.



 

Monday, 22 October 2018 09:36

En el CNB nos sumamos a la celebración de la Semana de la Ciencia 2018 el día 14 de noviembre a partir de las 5 de la tarde. Trás la proyección de la película documental Food evolution, se realizará un coloquio posterior con los científicos Lluís Montoliu y José Juan Sánchez Serrano, del Centro Nacional Biotecnología (CNB) Madrid y Josep Casacuberta, del Centre for Research in Agricultural Genomics (CRAG), Cerdanyola.

Food evolution es un documental dirigido por Scott Hamilton Kennedy y narrado (en inglés) por Neil de Grass Tyson. La película, con subtítulos en castellano, muestra la controversia que rodea al uso de organismos modificados genéticamente como alimentos, abordando el debate surgido entre científicos y consumidores sobre cómo alimentar a nuestra población en expansión de manera segura y sostenible.

Dirección: Centro Nacional Biotecnología, C/Darwin 3 (Campus Cantoblanco), Madrid 28049.

Fecha 14 de noviembre, 17:00, salón de actos

Aforo: 50 personas

Inscripción:

Friday, 05 October 2018 11:47

CNB joined the celebration of the European Researchers Night. Our institute hosted the activity “Tricks not to get lost in an information sea”  with the collaboration of more than 20 researchers from the center. The attendees enjoyed Susanna Manrubia and Carlos Pedrós divulgative talks, as well as three interactive workshops focused on exercising the critical spirit to discriminate between the immense amount of information (and misinformation) that surrounds us. Vaccines, homeopathy and nutrition trends were used as examples.

Thursday, 04 October 2018 12:19

Jesús Blázuez, researcher at CNB, has recently published an article in Annual Review of Microbiology, in collaboration with scientists from Hospital Virgen del Rocío and Hospital Ramón y Cajal reviewing antibiotic resistance in bacteria.

Tuesday, 02 October 2018 15:19

El pasado fin de semana fallecía el periodista y divulgador científico José Cervera.

 

Tuesday, 25 September 2018 17:26

The Spanish Research Council (CSIC) has confirmed, together with the Ministry of Science, Innovation and Universities, the installation of a last-generation cryoelectron microscope at the National Center for Biotechnology (CNB). An investment of more than eight million euros will be made in what will be the first microscope of these characteristics in Spain.

Thursday, 20 September 2018 14:33

A study published in PLoS Pathogens by the group of Pablo Gastaminza (CNB) in collaboration with structural biologists at the CNB and clinical researchers at CIBERehd / Clinic Hospital-IDIBAPS.

Tuesday, 18 September 2018 14:01

The XXIII CNB Seminar Series and XII CNB Junior Seminar Series will start on September 25 with an inaugural conference by Prof. Richard Henderson (LMB, Cambridge, UK), 2017 Nobel Prize laureate in chemistry.

CNB Seminars will be held on Fridays at 12:00 in the CNB Conference Room.

Monday, 17 September 2018 16:22

A collaborative study, recently published in eLife by the Centro Nacional de Biotecnología (CNB, Madrid) and the Institut de Biologie de l'Ecole normale supérieure (IBENS, Paris), unveils a mechanism that controls the abundance of specific epigenetic marks in response to an environmental signal, in this case light conditions, to promote an adequate developmental pattern in plants. The components of this mechanism are conserved in other eukaryotic organisms, including humans, in which they influence cell proliferation and differentiation. Conclusions of this study are thus relevant to characterize essential processes in other species.

Tuesday, 11 September 2018 17:18

The functions performed by the concentric shells of multilayered dsRNA viruses require specific protein interactions that can be directly explored through their mechanical properties. We studied the stiffness, breaking force, critical strain and mechanical fatigue of individual Triple, Double and Single layered rotavirus (RV) particles. Our results, in combination with Finite Element simulations, demonstrate that the mechanics of the external layer provides the resistance needed to counteract the stringent conditions of extracellular media. Our experiments, in combination with electrostatic analyses, reveal a strong interaction between the two outer layers and how it is suppressed by the removal of calcium ions, a key step for transcription initiation. The intermediate layer presents weak hydrophobic interactions with the inner layer that allow the assembly and favor the conformational dynamics needed for transcription. Our work shows how the biophysical properties of the three shells are finely tuned to produce an infective RV virion.

Monday, 03 September 2018 16:16

El INFORME SOBRE TRANSPARENCIA ANIMAL 2018 se presentará el próximo miércoles, 5 de septiembre, a las 11:30, en la Residencia de Estudiantes del CSIC.

Wednesday, 29 August 2018 12:42

This study, published in EMBO Reports, not only establishes for the first time a functional relation between c-Myc and Max but also raises novel and intriguing questions regarding the specific contribution of each of these factor to a series of relevant biological functions.

Tuesday, 14 August 2018 11:48

Trucos para no perderse en un mar de información: viajes en el tiempo y pseudociencias.

En este evento discutiremos la necesidad de ejercer el espíritu crítico ante la inmensa cantidad de información (y desinformación) que nos rodea. Lo haremos a través de dos ejemplos: examinando paradojas, consistencia y ciencia en las películas de viajes en el tiempo y cuestionando las afirmaciones que hacen distintas pseudociencias (y por tanto su validez).

MÁS INFORMACIÓN Y RESERVA DE PLAZAS AQUÍ

Monday, 13 August 2018 11:07

The Spanish Association of Scientists (Asociación Española de Científicos, AEC) has awarded the AEC PLAQUE OF HONOR 2018 to Lluís Montoliu in acknowledgment of his internationally relevant research in the field of genomic regulation and the development of animal models of rare diseases, as well as for his dissemination activities, with special emphasis on contact with patients and transparency in animal experimentation.

The AEC, founded in 1971, has granted these AEC Honor Plaques annually already for more than 20 years to scientists and professionals, as well as to companies, associations and institutions that stand out for their contributions to RDI in Spain. The distinctions will be presented in November in Madrid during the Annual Dinner of the AEC.

Friday, 10 August 2018 16:52

Reoviruses build new organelles (viral factories) in the cytoplasm of infected cells to be able to replicate themselves. This study reveals that the human reovirus modifies and uses endoplasmic reticulum (ER) membranes to produce its replication organelles. The reovirus proteins σNS and μNS are in charge of ER remodeling and the use of this modified ER as scaffold for the assembly of viral factories.

Thursday, 26 July 2018 14:11

The Aplastic Anemia and MDS International Foundation (AAMDSIF) has awarded Isabel Merida's study on the role of diacylglycerol kinase zeta in early stages of aplastic anemia with a two-year grant.

AAMDSIF is the world's leading nonprofit health organization dedicated to patients afflicted with bone marrow failure disease. For nearly 30 years, AAMDSIF has provided research grants totaling in excess of $4 million to an international group of more than 75 researchers to help advance the understanding and treatment of aplastic anemia, myelodysplastic syndromes (MDS), and paroxysmal nocturnal hemoglobinuria (PNH).

Thursday, 26 July 2018 10:27

The Álvaro Entrecanales Foundation and the Jerôme Lejeune Foundation have awarded Cristina Rodríguez from the Isabel Mérida group at the CNB the predoctoral fellowship in basic and clinical research in Down Syndrome, Trisonomy 21.

Tuesday, 24 July 2018 16:09

At the “Microbiology and Society: Challenges” meeting of the Teaching and Dissemination Group of the Spanish Society of Microbiology (SEM), the president of the society, Prof. Antonio Ventosa, expressed the recognition of SEM to Professor Miguel Vicente for his work to disseminate Microbiology. In this event, which took place on July 19 in Madrid, a plaque acknowledging his activity since the 1980s to bring science closer to society was presented to Prof. Vicente.

Monday, 18 June 2018 16:45

12ª edición del Premio ISTT concedida a Lluis Montoliu, científico del Centro Nacional de Biotecnología del CSIC (CNB-CSIC). El galardón reconoce las aportaciones de sus investigaciones con YAC a la expresión de transgenes en ratones modificados genéticamente. El premio también es un homenaje a su papel esencial en la ISTT, de la que fue el primer presidente.

Thursday, 17 May 2018 12:40

The bacterium Clostridium botulinum contains small DNA molecules needed to produce botulinum toxin. Researchers at the Spanish National Center for Biotechnology and the Biological Research Center have discovered that to segregate these DNA molecules during bacterial cell division, a protein bends and twists the DNA, forming double-ring structures. Knowledge of how these molecules are maintained and distributed during cell division is key to the development of measures aimed at controlling this toxin.

Monday, 07 May 2018 16:46

Organizations of the industry, and associations connected to R+D+i express their support towards research, backing the petition of the Severo Ochoa and María de Maeztu alliance (SOMMa), with the Spanish National Center for Biotechnology of CSIC among them, which advocates in favour of the political class acting to clear the administrative problems currently affecting science in Spain. SOMMa and the organizations supporting this initiative represent close to 6,800 businesses, societies, centres and research units, which give employment to more than 500,000 people in Spain, and have an economic activity equivalent to 10,53 % of the gross domestic product

Thursday, 26 April 2018 17:12

A study led by Isabel Fernández and Cristina Risco of the Spanish National Center for Biotechnology of the CSIC has received the 2017 award for outstanding paper within the life sciences, an annual prize given by the European Microscopy Society. Published in Nature Communications in November of last year, the paper earned this distinction based on the quality and novelty of the microscopy techniques used.

Monday, 16 April 2018 16:04

A lack of p38γ and p38δ increases the efficiency of innate immune cells against systemic Candida albicans infection. This lack also reduces the elevated inflammation behind organ damage. Drugs that inhibit these proteins have potential use as therapy against systemic candidiasis, a condition affecting thousands of people each year worldwide.

Monday, 09 April 2018 18:16

The hormone triggers the defense response in non-vascular plants against such external stresses as pathogens and insects. Led by researchers from the Centro Nacional de Biotecnología of CSIC (CNB-CSIC), the study has also identified the key steps in the synthesis of the hormone and the signaling pathway governing the activation of the plant defense response.

Wednesday, 28 March 2018 13:08

A study shows that the CXCR4 chemokine receptors form aggregates in the cell membrane to be activated and carry out their function. This aggregation process is regulated by the presence of a ligand, by membrane proteins, and by the cytoskeleton. Preventing the formation of these aggregates might be used as a therapeutic strategy against HIV, tumour metastasis, or autoimmune diseases

Tuesday, 27 March 2018 14:15

TIE1 promotes branching in Arabidopsis, leading to bushier plants. TIE1 carries out this function by interacting with BRANCHED1, another protein widely studied for its role in modulating plant architecture. Defining the processes that modulate branching in crop species might help to optimise agricultural production.

Thursday, 22 February 2018 17:53

¡A new device enables lateral stretching of DNA molecules by applying force in a very controlled manner. Combining this technique with advanced fluorescence microscopy methods allows experiments that require visualization of DNA while it is being manipulated. This integration of state-of-the-art technologies is a powerful tool for molecular biology and biophysics studies.

Thursday, 08 February 2018 15:41

A study funded by the Fundación Domingo Martínez shows that the protein superoxide dismutase 3 (SOD3) is essential for reprogramming the blood vessels that supply tumours and enhance the effect of antitumour drugs. The results, published in the journal Nature Communications, open a new route to improving the effectiveness of existing cancer treatments

Friday, 26 January 2018 15:04

Tumour cells with a large number of mitochondria are more sensitive to chemotherapy. This might explain why some cells die after anti-tumour treatment while others that are genetically identical can survive and cause the cancer to reappear. Mitochondria number might be used to predict patient sensitivity to a specific treatment.

Thursday, 25 January 2018 16:03

The ParB non-specific binding domain for DNA and other proteins allow it to organize and condense the genetic material for bacterial division. This domain is described by scientists from the Centro Nacional de Biotecnología of the CSIC (CNB-CSIC) in a recent study in the journal eLife.

Monday, 22 January 2018 11:46

BMI1, a protein linked to stem cell maintenance in the heart, changes function in cell damage conditions and promotes cardiac stem cell differentiation. These findings are reported by scientists from the Centro Nacional de Biotecnología (CNB-CSIC) in a paper published in the journal Cell Death & Differentiation.

Wednesday, 10 January 2018 10:00

The external surface of some viruses that infect fungi have unanticipated enzyme activity. This is the conclusion of a study published in the journal PLoS Pathogens that analyzes the capsid structure of double-stranded RNA fungal viruses. Evolving to acquire these new functions would have allowed the viruses to establish a symbiotic relationship with their hosts

Tuesday, 02 January 2018 13:46

Plants use an alternative, previously unknown route to produce jasmonate. This hormone is of great importance in defence against pathogens and in stress situations. Unravelling the details of phytohormone production mechanisms can help to obtain more efficient, resistant crops

Tuesday, 02 January 2018 10:31

A study by scientists at the Centro Nacional de Biotecnología of the CSIC (CNB-CSIC) describes a new division system in Salmonella. This pathogenic bacterium uses this mechanism when it finds an acidic environment within the cell it has infected. The existence of this second division system, an alternative to that which was previously considered unique, offers possibilities for the development of antibiotics to fight intracellular infections.

Friday, 22 December 2017 12:04

Más de 600 invitados de todas las edades han participado presencialmente en las celebraciones del vigesimoquinto cumpleaños del Centro Nacional de Biotecnología del CSIC. A ellos se suman más de 6000 visitantes virtuales que, a través del nuevo blog de divulgación, el boletín de noticias y diez nuevos audiovisuales, han participado este año de la ciencia y las celebraciones del centro. Todas las actividades quedan enmarcadas por una exposición que recoge la historia del CNB-CSIC en los últimos 25 años.

Thursday, 14 December 2017 10:50

The structure of encapsulins –semiorganelles found in some species of bacteria– has been deciphered using electron cryomicroscopy techniques. In vitro and in vivo experiments show that these semiorganelles are very stable and functional. Encapsulins could be useful for biotechnological applications such as biosensors or as vehicles for controlled drug release.

Tuesday, 05 December 2017 10:21

On 20 December 2017, the Centro Nacional de Biotecnología of the CSIC (CNB-CSIC) will hold the 25th edition of the traditional conference Advances in Molecular Biology by Young Researchers Abroad.

During the whole day, we will host short talks by young postdoctoral scientist working abroad.  Attendance is free and open to everybody.

Monday, 04 December 2017 17:29

Next 18 and 19 December, researchers from the different departments from CNB will explain their last scientific results at the XXV edition of the CNB Scientific Workshop that traditionally takes place before Christmas.

This year, same as last one, the programme includes participation by the PhD students from the CNB. Ther will be two sessions in which the young scientist will participate with short talks and two poster session during wich they will explain their work.

Friday, 17 November 2017 13:46

A study published in Nature Communications indicates that CD4+ T lymphocytes are able to act as antigen-presenting cells. This function could be exploited to develop a new generation of immunotherapies against cancer. This technology is protected by patent and has a business project to bring it to the market.

Tuesday, 14 November 2017 13:03

Mariano Esteban, investigador del Centro Nacional de Biotecnología del CSIC (CNB-CSIC), fue nombrado el pasado 31 de octubre presidente del Instituto de España (IdeE), institución considerada “el senado de la cultura española”.

Mariano Esteban es también, desde 2012, presidente de la Real Academia de Farmacia. El IdeE engloba las diez reales academias nacionales y se considera el máximo órgano exponente de la cultura española en el orden académico.

Mariano Esteban es pionero en el campo de las vacunas. Destacan sus trabajos con enfermedades víricas y parasitarias como el sida, la hepatitis C, chikungunya, malaria o leishmaniasis. Fue director del CNB de 1992 a 2003 donde continúa realizando su trabajo como investigador.

 

Friday, 10 November 2017 10:42

An organelle produced by the influenza virus transports the molecules of its genome needed to manufacture new viruses. The study involves a change in our knowledge of the virus that could lead to new drugs to combat it.

Monday, 06 November 2017 09:47

A study led by scientists from the Centro Nacional de Biotecnología of the CSIC finds fundamental genes for altering the intestinal mucosa. The research is a step toward development of an effective vaccine against Escherichia coli intestinal infections.

Friday, 03 November 2017 09:44

Scientists of the Centro Nacional de Biotecnología of the CSIC have identified a treatment that could end infections caused by antibiotic-resistant bacteria.  The study, published in the journal Cell, used one of the most deadly bacteria, Staphylococcus aureus.

Monday, 23 October 2017 10:26

In the face of candidiasis, monocytes readjust their metabolic processes to optimize the organism’s defensive response. This discovery suggests potential new therapeutic targets against one of the main pathogens that affects humans

Friday, 20 October 2017 10:18

Los centros centros y unidades distinguidos con las acreditaciones Severo Ochoa y María Maeztu, entre los que se encuentra el Centro Nacional de Biotecnología del CSIC, unen fuerzas con la creación de la nueva Alianza de Excelencia Severo Ochoa y María de Maeztu. El principal objetivo de esta iniciativa es promover y fortalecer internacionalmente a los centros y unidades acreditados con esta distinción, así como dar mayor visibilidad a la investigación que realizan.

Monday, 16 October 2017 17:19

A new method allows the design and construction of nanometric cages using proteins. The structures are able to self-assemble inside cells and living beings. This protein “origami” could have applications in the development of new methods for administering drugs, vaccines, or molecular machines

Monday, 16 October 2017 17:03

On 20 December 2017, the Centro Nacional de Biotecnología of the CSIC (CNB-CSIC) will hold the 25th edition of the traditional conference Advances in Molecular Biology by Young Researchers Abroad. Open call for talk proposals until November 30th.

Monday, 16 October 2017 10:49

Lower levels of defective viral RNA molecules can make influenza viruses that affect humans more dangerous. This finding could help to guide patient treatment and provide important information for the design of influenza prevention strategies. The study, led by Dr. Ana Falcón in the laboratory of Dr. Amelia Nieto, has just been published in the journal PLoS Pathogens

Friday, 13 October 2017 12:52

A study of Staphylococcus aureus infections shows that bacterial populations are organized as “microbial cities”. Some bacterial subpopulations secrete toxins, others adhere to organs, and others combat the immune system

Wednesday, 04 October 2017 13:45

El segundo de los actos que celebran el 25 aniversario del Centro Nacional de Biotecnología del CSIC (CNB-CSIC) se celebrará el próximo viernes 27 de octubre. En la jornada participarán como ponentes algunos de los más prestigiosos científicos del mundo en las áreas de biología molecular, microbiología, biología estructural, biología de sistemas y virología.

Thursday, 24 August 2017 13:11

Next September will begin the XXII CNB Seminar Series and the XI CNB Junior Seminar Series at the Centro Nacional de Biotecnología of CSIC

This course, the Series will be inaugurated by Prof. Fernando Martín (IMDEA Nanociencia and UAM) and includes 20 speakers considered international reference in different areas of research in Life Science.

The talks will be held on Fridays at noon in the CNB Conference Room.

Wednesday, 23 August 2017 09:46

On August 31 and September 1, young European scientists will meet to discuss the possibilities that synthetic biology offers for building the society of the future. The EUSynBio 2017 Symposium will take place in Madrid at the Centro Nacional de Biotecnología of the CSIC. Over these two days, there will be discussions of science and new strategies against environmental pollution, but also of the legal, ethical and social aspects of synthetic biology

Tuesday, 22 August 2017 11:13

A new perspective is needed that assesses pollution problems in all their complexity, as well as possible solutions for effective bioremediation strategies. Systems biology and synthetic biology offer the necessary tools to implement this new approach. This strategy opens the door to the use of microorganisms to reduce global problems such as climate change

Wednesday, 09 August 2017 10:51

Los microorganismos resistentes a antibióticos necesitan readaptar sus procesos metabólicos para no perder capacidad de supervivencia. Bloquear estos procesos de reorganización de la maquinaria interna de las bacterias puede ofrecer nuevas estrategias en la lucha contra los patógenos resistentes a antibióticos.

Friday, 28 July 2017 14:47

The high mutation frequency of some immunodeficiency genes determines the probability of changes that reverse the genetic defect that causes the disease. This is what researchers at the Centro Nacional de Biotecnología of the CSIC (CNB-CSIC) observed when analyzing in vitro the T lymphocytes of a patient with a primary immunodeficiency

Friday, 21 July 2017 10:07

Experts from across the continent recommend establishment of a European committee to review and evaluate the uses of new genetic tools. The new techniques are inexpensive, simple, rapid and have greatly expanded the range of potential applications; they are also moving millions of euros. Scientists consider it is time to launch a debate on the ethical and social implications of these tools, and to legislate their use and applicability.

Friday, 21 July 2017 08:47

Miguel Vicente, microbiólogo del Centro Nacional de Biotecnología del CSIC (CNB-CSIC), ha sido elegido vocal de la International Union of Microbiological Societies (IUMS). El científico apoyará a la nueva presidenta de IUMS para reforzar la conexión con las sociedades y las federaciones regionales, y será responsable de promover el conocimiento público de la Microbiología.

Monday, 17 July 2017 09:14

“100xCiencia.2” tendrá lugar del 2 al 3 de noviembre de 2017 en Alicante. Acudirán destacados científicos de 40 centros y unidades de investigación “Severo Ochoa” y “María de Maeztu”, respectivamente. La inscripción al congreso ya está abierta en la página web del evento.

Tuesday, 04 July 2017 09:35

A team of scientists has described a new association system between proteins that form signaling complexes involved in activating immune system cells. The assembly model involves a network of several aromatic amino acids at the transmembrane regions of the proteins in the complex

Wednesday, 21 June 2017 16:26

An article published today in the journal Immunity describes the strategy used by cells of the innate immune system against a generalized fungal infection. The authors establish the spleen as a key organ that activates the defences responsible for terminating the Candida fungus that colonizes the whole body. The study shows the role of IL-15 in this process and opens a path to new, more effective therapies for fungal infections.

Tuesday, 20 June 2017 14:53

A study published today in the journal PNAS describes what happens at the atomic level when a double-stranded nucleic acid molecule is stretched. Using computer simulation, scientists found a way to explain why DNA coils when it is stretched, whereas double-stranded RNA unwinds. This type of simulation could lead to powerful tools that will help to understand how the structural properties of nucleic acids influence their biological function.

Tuesday, 06 June 2017 12:45

According to a study lead by researchers at the Centro Nacional de Biotecnología of the CSIC the same genes that are activated in the absence of nutrients also induce the dormant state in plant buds to stop the formation of new branches. This pattern of gene expression to prevent growth in fasting situations is detected in both herbaceous and in woody plants.

Wednesday, 31 May 2017 16:52

A team of researchers reveals the machinery that allows viruses that affect bacteria (or phages) to multiply. Scientists have shown that Sak and Sak4 proteins are essential for the DNA replication of phages that infect some clinically relevant bacteria. These viruses are partly responsible for the ability of pathogenic bacteria to cause infection in humans.

Wednesday, 10 May 2017 11:16

For years, p38γ and p38δ have been largely unknown, and have only recently begun to capture scientists’ attention. Researchers at the Centro Nacional de Biotecnología of the CSIC (CNB-CSIC) study these proteins and review the latest work on them in an article published this week in the journal Trends in Biochemical Sciences. The authors highlight the role of these two unknowns in certain diseases and discuss their potential in the development of new treatments.

Thursday, 04 May 2017 14:59

Un estudio localiza la región celular donde se ensamblan estos virus, que pueden afectar gravemente a pacientes inmunodeprimidos, y visualiza cómo se forman. El hallazgo puede ayudar a diseñar antivirales para tratar enfermedades, así como virus que sirvan como herramientas terapéuticas.

Wednesday, 03 May 2017 15:31

El primero de los actos que celebran el 25 aniversario del Centro Nacional de Biotecnología del CSIC (CNB-CSIC) se celebrará el próximo viernes 5 de mayo. En la jornada participarán como ponentes antiguos miembros del CNB-CSIC que se han convertido en líderes en investigación e innovación biotecnológica. Presidirán la inauguración del acto la Secretaria de Estado Carmen Vela, el vicepresidente de CSIC Jose Ramón Urquijo y el Rector de la UAM José María Sanz, junto a miembros del equipo directivo del CNB-CSIC. El encuentro servirá de marco para la inauguración de una exposición que relata los 25 años de historia del centro.

Friday, 21 April 2017 10:57

The Calmette-Guérin bacillus is the treatment of choice for the most common type of bladder cancer. According to a study led by researchers at the Centro Nacional de Biotecnología of the CSIC, this bacterium activates the patient's natural killer cells, which are ultimately responsible for eliminating the tumor cells. Understanding the mechanism of action of this therapy could help to design new protocols and customize treatment of these cancers.

Wednesday, 29 March 2017 09:30

El ensayo clínico fase I de un procedimiento de vacunación basado en varios componentes combinados contra el virus VIH, causante del SIDA, ha concluido. La vacuna testada incluye un vector de ADN, un vector viral atenuado MVA y un componente proteico. Los resultados indican que el procedimiento de vacunación más efectivo consiste en administrar cada uno de los componentes por separado. El componente viral MVA ha sido desarrollado en los laboratorios del Centro Nacional de Biotecnología del CSIC.

Friday, 24 March 2017 18:22

Different forms of the DIDO protein regulate activation of the differentiation process in embryonic stem cells. Advances in regenerative medicine require a closer look at stem cell biology and the molecular mechanisms that govern their activity. The study has been published in the scientific journal Stem Cell Reports.

Thursday, 16 March 2017 12:35

Anna Tramontano, pionera de la biología computacional y estimado miembro de Comité Científico Asesor del CNB falleció el pasado 9 de marzo. El centro pudo contar con su valiosa experiencia y consejo en varias de sus evaluaciones, la última hace ahora un año.

Profesora de bioquímica en la Universidad de Sapienza de Roma, Anna Tramontano dedicó su vida a la investigación y fue una de los mayores exponentes de la bioinformática en todo el mundo. Permanecerá presente en la memoria de todos por su entusiasta dedicación y valiosas aportaciones a la ciencia. D.E.P.

Thursday, 16 March 2017 10:06

El próximo 7 de abril se celebrará en el CNB-CSIC el Workshop Mycobacterium: Molecular Microbiology organizado por los investigadores Miguel Vicente y Susanne Gola. El workshop contará como ponente invitada con Sabine Ehrt, del Weill Cornell Medical College de Nueva York. Junto a ella, otros siete ponentes completarán el panel de expertos que participará en el workshop.

Monday, 06 March 2017 10:57

Pulmonary inflammation associated with the severe acute respiratory syndrome (SARS) is caused in part by tiny RNA molecules produced by the virus. Infected rodents treated with inhibitors of these small RNAs reduced lung inflammation. These findings could lead to new forms of therapy for patients affected by the disease.

Friday, 17 February 2017 11:31

Con motivo del Día Internacional de la Mujer y la Niña en la Ciencia, los estudiantes de 6º de primaria del Colegio Príncipe de Asturias entrevistaron a cuatro investigadoras del Centro Nacional de Biotecnología del CSIC (CNB-CSIC). Susanna Manrubia, Ana Cuenda, Silvia Hormeño y Carmen Simón se sometieron a todas sus preguntas. Estas son algunas de ellas.

Friday, 17 February 2017 11:09

El Centro Nacional de Biotecnología del CSIC (CNB-CSIC) participa en un proyecto europeo cuyo objetivo es controlar la replicación del virus del sida sin necesidad de utilizar terapia con antirretrovirales.

Wednesday, 15 February 2017 16:09

The miniprotein Prli42 assists anchoring of the stressosome, a macrocomplex that acts as an antenna, to the bacterial membrane. The discovery, made with the participation of the Centro Nacional de Biotecnología (CNB) of the CSIC and the Universidad Autónoma of Madrid (UAM), was possible via a massive identification of the initial (N-terminal) residue of proteins produced by an organism.

Friday, 03 February 2017 09:41

Throughout 2017, a whole range of scientific events, outreach activities other events will take place to celebrate the 25th aniversary of the Centro Nacional de Biotecnología of the CSIC.

Friday, 27 January 2017 13:08

An article published in Nature Communications shows that some microorganisms have a hitherto unknown system for detection and correction of errors in the genetic material. This mechanism prevents some bacteria, such as Mycobacterium tuberculosis, from easily developing resistance to antibiotics. This research opens the door to the development of new strategies to combat antibiotic resistance of pathogenic bacteria. It can also be used to improve performance in biotechnological processes of industrial interest

Thursday, 19 January 2017 16:45
Next March 27 and 28, 2017 will take place the 4th Madrid Meeting on Dendritic cells and Macrophages aimed to promote the interaction between researchers working in Spain on dendritic cells and macrophages in the context of immune response, inflammation and metabolism.
Tuesday, 10 January 2017 11:40

One of the basic features that farmers must manipulate to improve crop yield is the branching pattern in plants. CNB-CSIC researchers have identified several genes that regulate new branch formation as a function of ambient light. Detailed knowledge of these molecular processes is important for developing methods to control plant growth and optimize agricultural production

Wednesday, 07 December 2016 13:14

On 22 December 2016, the Centro Nacional de Biotecnología of the CSIC (CNB-CSIC) will hold the 24th edition of the traditional conference Advances in Molecular Biology by Young Researchers Abroad.

During the whole day, we will host short talks by young postdoctoral scientist working abroad. Attendance is free and open to everybody.

Wednesday, 30 November 2016 17:49

Next 20 and 21 December, researchers from the different departments from CNB will explain their last scientific results at the XXIV edition of the CNB Scientific Workshop that traditionally takes place before Christmas.

This year, same as last one, the programme includes participation by the PhD students from the CNB. Ther will be two sessions in which the young scientist will participate with short talks and two poster session during wich they will explain their work.

Tuesday, 29 November 2016 10:28

All the experts who participated on 23 November in the Global ImasT agree: we must take action or we will miss the train of modernity. A new collaborative model is needed between the public and private sectors to promote entry of venture/risk capital into the country, as well as a commitment by the political class to innovation and to education that awakens adventurous talent and enhances entrepreneurial spirit.

"It is imperative to undertake, to act and to do. We must stand on tiptoe and look at the horizon. We must learn to dream," says Iñaki Gabilondo.

Wednesday, 16 November 2016 11:07

The Flow Cytometry Service at the Centro Nacional de Biotecnología of the CSIC (CNB-CSIC) has been designated by Beckman Coulter as a Flow Cytometry Reference Centre. This nomination recognizes the quality of the work by the service, which will form part of a European network of leading centres in this technique.

Monday, 14 November 2016 15:07

A collaborative strategy among weaker communities leads to a more beneficial overall outcome than submission to the strongest community. In addition, the weaker competitors in a network of networks hold the fate of the group in their hands, independently of the actions of the most powerful. This is the finding of a study recently published in the journal Nature Communications. Microcredit networks among the peoples of India, collaboration among groups for Ebola research, or conservation of fragmented habitats such as that of the Pyrenean brown bear are just some examples in which this model is applicable.

Thursday, 10 November 2016 15:35

The event will take place simultaneously on 23 November at 12 venues to activate the ecosystems of innovation and entrepreneurship in Spain. The 4th Edition of Global I + T will be inaugurated by the journalist Iñaki Gabilondo. Daniel Isenberg will be among the primary speakers of the day. At the CNB-CSIC, participating speakers will include as Ion Arocena (director of ASEBIO) and Enrique Castellón (CRB Inverbio), to promote synergies among the various stakeholders in the biotechnology sector.

Monday, 07 November 2016 13:28

The new INPhINIT programme promoted by the Obra Social "la Caixa" will finance three-year contracts for 57 students to carry out doctoral studies in leading research centres in Spain. Among other possibilities, the candidates can opt for one of the 36 project proposals in laboratories at the Centro Nacional de Biotecnología of the CSIC (CNB-CSIC).

Thursday, 20 October 2016 10:18

The European Commission recently granted eight million euros to develop a project called Rafts4Biotech, coordinated by Daniel López from the Centro Nacional de Biotecnología of the CSIC (CNB-CSIC). The project involves 12 institutions from all over the continent that seek to exploit the lipid rafts in synthetic bacteria to optimise processes of interest to the pharmaceutical, cosmetic and food industries.

Tuesday, 18 October 2016 12:13

For the third consecutive year, QUO magazine has selected the 12 most prominent researchers in Spanish science. Among them is Mariano Esteban, a virologist at the Centro Nacional de Biotecnología of the CSIC (CNB-CSIC), who runs the poxvirus and vaccines laboratory at the centre.

Wednesday, 05 October 2016 13:41

On 22 December 2016, the Centro Nacional de Biotecnología of the CSIC (CNB-CSIC) will hold the 24th edition of the traditional conference Advances in Molecular Biology by Young Researchers Abroad. Open call for talk proposals until November 30th.

Wednesday, 05 October 2016 10:31

El pasado viernes día 30 de septiembre, los científicos del CNB-CSIC se unieron a las celebraciones europeas por la Noche de los Investigadores. El centro se convirtió por unas horas en un escenario hollywoodiense el que público de todas las edades pudo interaccionar con los investigadores para descubrir los secretos de la ciencia escondida detrás de superproducciones de ciencia-ficción como Blade Runner, Avatar o Marte.

Friday, 23 September 2016 10:19

The rhodopsin, a protein almost unknown until a few years ago, allows many marine bacteria and archaea to capture the sun's energy and use it to grow faster and survive in the absence of nutrients. An article with the participation of the Centro Nacional de Biotecnología of CSIC (CNB-CSIC) reviews all the studies done to date about these microorganisms. The analysis reveals the importance of rhodopsin in marine ecology and its great potential for biotechnological applications.

Tuesday, 13 September 2016 16:06

Next October will begin the XXI CNB Seminar Series and the X CNB Junior Seminar Series at the Centro Nacional de Biotecnología of CSIC

This course, with the sponsorship VWR, the Series will include 21 speakers considered international reference in different areas of research in Life Science. Also, this year will take place two scientific workshops.

The talks will be held on Fridays at noon in the CNB Conference Room.

 

Tuesday, 13 September 2016 12:17

Next Monday September 26 the CNB will celebrate a symposium in honor of Juan Ortín. The virologist has belonged to the CNB since its beginings. For his retirement, the center brings together some of the best virologists in a symposium held in his honor under the title "Old and New Perspectives in Virology". In this event will participate as speakers Richard Randall of the University of St Andrews (UK), Fernando Rojo, Jaime Martin-Benito, Luis Enjuanes and Mariano Esteban, all of them from the CNB.

Wednesday, 31 August 2016 11:08

The protein RepC only acts on negatively supercoiled plasmids (circular DNA molecules present in bacteria), this means, twisted in counter to the normal winding direction of the double helix. This is the conclusion of a recently published study by researchers at the Centro Nacional de Biotecnología of the CSIC (CNB-CSIC). The work sheds light on the mechanism of replication of these circular DNA molecules that, among other things, allow certain bacteria become resistant to antibiotics.

Wednesday, 24 August 2016 14:59

A recent study found that Salmonella -an intracellular bacterial pathogen that infects humans- promotes the elimination of some of the bacteria inside the eukaryotic cell taking advantage of a process called aggrephagy. This way, the pathogen effectively controls the size of its progeny. This mechanism prevents the death of the host cell by an excessive number of bacteria inside it and promotes persistent infection over time.

Thursday, 18 August 2016 15:09

A study conducted jointly by scientists from the United States and Spain shows how Hsp70 chaperones work. As if they were nanomachines, the Hsp70 generate force on other proteins through collisions and stretching, to break bonds between them or transport them through the membranes of different cell compartments.

Tuesday, 19 July 2016 14:58

Two outstanding representatives of CRISPR-Cas have come together to tell the story of a technique that, based on a secret closly guarded by bacteria for millions of years , has revolutionized the world of genetic editing. In a review article, the authors pay homage to basic research that, sooner or later, yields benefits.

Tuesday, 19 July 2016 10:08

Scientists at the Centro Nacional de Biotecnología of the CSIC (CNB-CSIC) have identified p21 as a key player in regulating inflammation. This protein controls macrophage transformation from an active, proinflammatory state to an anti-inflammatory, healing role. Maintaining an adequate balance of activation in the immune system is essential for coping with conditions such as sepsis, cancer or autoimmune disease

Wednesday, 06 July 2016 11:42

Scientists at the Centro Nacional de Biotecnología of the CSIC (CNB-CSIC) and the ALBA Synchrotron have developed the 3D map of the interior of cells affected by the hepatitis C virus. They could observe the changes caused by the hepatitis C virus in the endoplasmic reticulum and mitochondria of infected cells. These defects were reversed by treatment with the most common antiviral drugs for hepatitis C.

Wednesday, 29 June 2016 10:02

Marginal zone lymphomas are tumours that affect B cells. There are several types, but they are rare and there is no specific treatment for them. An international study shows that an excess of the protein NKX2-3 promotes development of these cancers by altering normal B lymphocyte activity. The study suggests new targets for the treatment of these lymphomas and offers a new model for research on the disease.

Tuesday, 28 June 2016 10:45

The European consortium CARE-MI has released the first results of its phase I/II clinical trial with cardiac stem cells for large myocardial infarction. At six months post-treatment, initial results indicate that the treatment is safe. The final results on safety and efficacy will be made public in 2017

Tuesday, 21 June 2016 12:12

The Centro Nacional de Biotecnología of the CSIC (CNB-CSIC) participates as a collaborator institution in three of the best Spanish masters, according to the annual ranking published by El Mundo.

Wednesday, 15 June 2016 12:53

Next Monday 27 of June will take place for the second consecutive year the Workshop by CNB PhD Students.

Starting at 14.30pm, two PhD representatives from each CNB department will give a short talk addressed to their fellows. This workshop is specifically addressed to the PhD CNB community.

Monday, 23 May 2016 11:37

Roberto Solano, of the Centro Nacional de Biotecnología, is among 58 researchers named today as new members of EMBO. This distinction is awarded annually to outstanding scientists worldwide in recognition of their research excellence in the life sciences

Thursday, 12 May 2016 14:25

Breaking-Cas is a web tool, developed at the Centro Nacional de Biotecnología of the CSIC (CNB-CSIC), that facilitates the design of gene editing experiments using the well-known CRISPR/Cas technique.The programme enables the design of the guide RNA (gRNA) needed for this technique, which is specific for each experiment.The software will allow researchers around the world to carry out CRISPR genome editing in nearly 700 eukaryotic organisms.

Tuesday, 26 April 2016 14:34

Bioinformaticians at the Centro Nacional de Biotecnología (CNB-CSIC) have developed a new version of MBROLE, a web server that analyses the results of metabolomics studies. This tool allows interpretation and helps to make biological sense of the lists of hundreds of metabolites that molecular biology techniques obtain for an organism.

Thursday, 21 April 2016 15:04

The Centro Nacional de Biotecnología (CNB-CSIC) joins the celebrations of World Intellectual Property Day that will take place around the world on Tuesday, 26 April. Three speakers from the biotechnology industry will share their experiences on the role of intellectual property in their business models

Monday, 18 April 2016 16:43

Juan Ortín is a pioneer in the structural and functional analysis of replication and gene expression in influenza virus. His research lines have been central to understanding this virus. Ortín has formed part of the Centro Nacional de Biotecnología (CNB-CSIC) since its opening in the 1980s.

Thursday, 14 April 2016 12:07

On 18 and 19 April, the Centro Nacional de Biotecnología of the CSIC (CNB-CSIC) welcomes the first Congress of the AdenoNet network. This conference will bring together leading scientists in research on adenovirus, a virus that can cause disease but can also be useful for new therapeutic treatments. The congress will address the use of these viruses in gene therapy, virotherapy for cancer, as well as their pathology and molecular structure.

Friday, 01 April 2016 14:57

The Andigena potato variety produces its tubers in winter, when days are short and temperatures are low. Scientists at the Centro Nacional de Biotecnología of the CSIC (CNB-CSIC) have discovered the molecular mechanism that allows the plant to identify day length and start tuberization. The UN considers the potato as a key food in the fight against hunger. Understanding the molecular mechanisms that govern its life cycle could be useful for adapting its growth to warm tropical areas where yields are much lower.


Friday, 01 April 2016 11:21

Histones regulate the organisation of DNA throughout the cell cycle. Changes in these proteins determine the degree of compaction of the genetic material and expression of its genes. This is what is termed epigenetics: information not contained in the genes but that influences them. Scientists at the Centro Nacional de Biotecnología of the CSIC (CNB-CSIC) have analysed how the combination of several modifications allows epigenetic information to be maintained when cells divide.

Thursday, 17 March 2016 10:16

The brain consumes 20% of the energy produced by our body. This organ holds many secrets and the scope of its function is still being studied. Neurological disorders are diseases of the central and peripheral nervous systems. With population aging, diseases such as epilepsy, multiple sclerosis, migraine, Alzheimer's or Parkinson's affect more and more people. Hundreds of millions of patients worldwide suffer from these diseases.

Tuesday, 08 March 2016 09:19

The proposal of the Centro Nacional de Biotecnología of CSIC and the University of Santiago de Compostela is one of the six winning projects of the Discovery Fast Track programme of the company GSK. The initiative is focused on searching new drugs against cancer.  

Monday, 07 March 2016 16:44

3 million Spaniards suffer from one of the diseases classified as rare. Albinism is one of these and affects 1 in every 17,000 inhabitants. At the Centro Nacional de Biotecnología (CNB-CSIC), Lluis Montoliu’s laboratory seeks to broaden our knowledge of this disease to improve diagnosis and find customized therapies for these patients. The CNB-CSIC joins the celebration of this day to promote understanding and social awareness of these diseases.

Monday, 22 February 2016 18:09

The deregulated expression of a micro-RNA identified as miR-148a facilitates the development of autoimmune diseases such as lupus. This is shown in a study published in the journal Nature Immunology with the collaboration of scientists from the USA and the Centro Nacional de Biotecnología (CNB-CSIC).

Monday, 15 February 2016 12:56

The European Research Council has awarded Fernando Moreno a Consolidator Grant. The amount granted amounts to nearly €2 million, which will allow him to consolidate his research group over the next five years and continue to develop their studies.

Monday, 15 February 2016 11:06

The research group led by Dr Mar Valés-Gómez at the National Center for Biotechnology (CNB-CSIC), has filed at the Spanish Patent and Trademark Office a new patent application for a method which predicts and monitors the therapeutic response of bladder cancer patients to anti-cancer immunotherapy based on the intravesical administration of Bacille Calmette-Guérin (a very common treatment for this condition).

This new method has been developed together with scientists from the Hospital Infanta Sofía (Madrid) and the National Institute for Biological Standards and Control (NIBSC) from UK.

The method consist in a urine analysis and in is simpler, more reliable, and less invasive than other alternative methods. It is useful for predicting bladder cancer recurrence following treatment before new tumor cells are released to the urine, allowing early selection of patients for alternative anti-cancer therapies.

Tuesday, 09 February 2016 12:14

The Community of Madrid has awarded the Miguel Catalán Prize for researchers under 40 years to Fernando Moreno, a researcher at the Centro Nacional de Biotecnología of the CSIC (CNB-CSIC).

Friday, 05 February 2016 16:10

Spanish researchers from ten centers, among them the group of Mar Valés at the Centro Nacional de Biotecnología of the CSIC (CNB-CSIC), have joined to form the Network of Excellence and Innovation in Exosomes (REDIEX in its Spanish initials). This initiative aims to promote the development of new therapeutic strategies for cancer and parasitic diseases.

Thursday, 04 February 2016 12:05

The carnivorous plant known as the Venus flytrap knows how to count, and uses this ability to decide when to trap and digest their victims. This is shown in a study published in Current Biology in which researchers from the Centro Nacional de Biotecnología of the CSIC (CNB-CSIC) participated, with scientists from German and Australian centres.

Media

Tuesday, 02 February 2016 10:01

The laboratory of researcher Mariano Esteban, at the Centro Nacional de Biotecnología of the CSIC (CNB-CSIC), forms part of the new European alliance for a vaccine against HIV (EHVA). The association is made up of 39 institutions from around the world and funded with 28.2 million euros. Its aim is to foster the development of new preventive and therapeutic approaches with which to face the challenge of HIV/AIDS.

Monday, 01 February 2016 09:51

Researchers at the Centro Nacional de Biotecnología of the CSIC (CNB-CSIC) have published a study in the journal Nucleic Acids Research that sheds light on the molecular mechanism used by bacteria to incorporate changes into their genome through horizontal gene transfer.

Friday, 29 January 2016 09:42

It has been granted in the United States (US) a patent which is being developed at the Centro Nacional de Biotecnología of CSIC (CNB-CSIC) by the former group of researchers led Juan Pablo Albar.

The patent was granted in Europe in 2013. Proteobotics, a spin off of the CSIC headed by Antonio Ramos, has a development contract with an option to license this patent.

The patent is a method to integrate data from mass spectrometry which greatly increases the performance in identifying peptides and proteins

Tuesday, 26 January 2016 13:00

Researcher Roberto Solano, of the CNB-CSIC Department of Plant Molecular Genetics, is among the most influential scientific minds in the world for the second consecutive year according to Thomson Reuters.

Monday, 25 January 2016 11:30

Researchers at the Centro Nacional de Biotecnología (CNB-CSIC), in collaboration with other European centres, have reconstructed the three-dimensional structure of the CCR4-NOT complex. CCR4-NOT consists of eight proteins involved in cell division. Its malfunction can lead to serious problems such as cardiomyopathy or various types of cancer

Thursday, 21 January 2016 19:00

A study by researchers at the Centro Nacional de Biotecnología of the CSIC (CNB-CSIC) indicates that postnatal brain activity is essential for establishing connections between the two hemispheres. Cux1 and Kv1 are two proteins involved in this process. Their absence leads to a “wiring” defect similar to that seen in mental disorders such as autism. According to the study, in rodents there is a time period after birth in which it would be possible to recover the lost connections

Media

Tuesday, 19 January 2016 20:56

Last 14th January 2016 the Royal Academy of Pharmacy of Spain celebrated the Solemn Opening Session for the Academic Course 2016. During the event, the researcher Mariano Esteban from the Centro Nacional de Biotecnología of the CSIC (CNB-CSIC) took office for a second consecutive term as president of the Royal Academy of Pharmacy of Spain.

Thursday, 17 December 2015 11:38

Doctor Pablo Gastaminza, from the Department of Molecular and Cellular Biology and on behalf of the research group led by Dr. Xavier Forns in the Hospital Clinic in Barcelona, attended yesterday the Awards Ceremony for the winner projects of the third edition of the Research projects in HIV, Hepatitis and Hematology-Oncology 2015 Fellowship Program by the pharmaceutical Gilead. Dr. Gastaminza will be on board for a project called “Virological and immunological factors associated with hepatitis C and hepatitis B virus infection recurrence after treatment discontinuation”. He will contribute by providing his experience and reagents required for the study of the genetic and phenotypical characteristics of the hepatitis C virus, isolated from patients who suffer from reoccurring infections after the completion of their treatment with direct-acting antivirals.

Monday, 14 December 2015 17:18

On 22 December 2015, the Centro Nacional de Biotecnología of the CSIC (CNB-CSIC) will hold the 23rd edition of the traditional conference Advances in Molecular Biology by Young Researchers Abroad. Attendance is free and open to everybody.

Thursday, 10 December 2015 18:08

Next 15 and 16 December, researchers from the different departments from CNB will explain their last scientific results at the XXIII edition of the CNB Scientific Workshop that traditionally takes place before Christmas.

Friday, 27 November 2015 20:02

Researchers from several European centres have announced the end of the patient recruitment phase for the CAREMI clinical trial. This assay hopes to confirm the safety and efficacy of a new therapy based on donor-derived allogeneic stem cells to treat myocardial infarction patients. Preliminary data are promising, although the final results are expected in 2017.

 

Wednesday, 25 November 2015 17:25

Natural killer (NK) cells are white blood cells that detect and eliminate virus infections. Unlike T cells, they need not have seen the virus previously to be able to respond (they form part of the innate immune response); to be effective, however, they must undergo a very precise maturation process. Thanks to the study of a patient with congenital immunodeficiency due to the lack of the gene that encodes CD247, a protein essential for T cell receptor assembly, CNB-CSIC researchers found that this protein is also indispensable for correct NK cell maturation.

Tuesday, 17 November 2015 11:51

On november 25th the CNB will participate in the Global ImasT, an event dedicated to technological innovation that will take place at a national level. Other 14 institutions, among wich some of the best universities and research centres can be found, will participate in the event.

Friday, 13 November 2015 16:07

Two scientists at the Centro Nacional de Biotecnología of CSIC are among the 14 young researchers selected to participate in the program ComFuturo. Their projects will be funded during three years by CSIC and other eight private institutions that sponsor the initiative.

Friday, 30 October 2015 01:15

Scientists at the Centro Nacional de Biotecnología of the CSIC (CNB-CSIC) have developed a vaccine against SARS. This new version of the vaccine solves the safety problems of the previous prototype and continues to provide full protection against the disease in mouse models.

Media

Thursday, 22 October 2015 04:14

Nine senior African women researchers will be deepening and sharing knowledge in prestigious Spanish institutions through Women for Africa’s project "Science by Women".Thirty entries from all over Africa applied for the selection process. Two of the selected researchers will stay at the laboratories of the CNB.

Monday, 19 October 2015 22:10

On 22 December 2015, the Centro Nacional de Biotecnología of the CSIC (CNB-CSIC) will hold the 23rd edition of the traditional conference Advances in Molecular Biology by Young Researchers Abroad.

Saturday, 03 October 2015 00:07

The CNB aims to incorporate up to eleven postdoctoral scientists through two-year working contracts, financed by a Severo Ochoa Centres of Excellence grant

Thursday, 24 September 2015 23:04

To proliferate, bacteria such as Escherichia coli form a ring that constricts the membrane until the original cell becomes two. The FtsZ protein is the basis of this structure, but the process would not be possible without the support of many other proteins. In a recent article, CNB-CSIC researchers explain how this group of proteins is coordinated so that nothing goes wrong.

Wednesday, 16 September 2015 22:02

CNB scientists have shown how the protein ALIX regulates phosphate transporters on the cell membranes of the plant Arabidopsis thaliana. When the amount of phosphate in the milieu is sufficient, the transporters are internalised from the membrane to the cell’s degradation machinery in the vacuoles. The plant is thus able to maintain its internal phosphate levels constant.

Monday, 07 September 2015 23:59

International travel and trade as well as rising temperatures bring diseases to our country that we thought were confined to the tropics. A group of scientists from the CNB wants to fight them, both here and in their place of origin. Starting today, anyone who wants to help them achieve this can do so through the PRECIPITA platform of the Spanish Foundation for Science and Technology.

Friday, 04 September 2015 00:57

Biogen Foundation has announced the X edition of the Prizes for Young Researchers. Two different awards will be given, one for clinical research and another one for basic research. The aim is to award the best works of young scientist both in Spain and abroad.

 

Saturday, 22 August 2015 08:46

Protein ω2 is tightly related to antibiotic resistance of some pathogenic bacteria such us Streptococcus, Enterococcus or Staphylococcus. A group of researchers at the CNB has identified how this protein acts in order to modulate the transcription of certain genes which allow microorganisms became resistant to antibiotics and survive clinical treatments.

Wednesday, 12 August 2015 22:56

The XX CNB Seminar Series will start on 23 September 2015 with a conference by the Centre for Genomic Regulation researcher James Sharpe.

With the collaboration of VWR, the 2015-2016 Seminar Series will held talks of 13 renowned scientists in the field of life sciences.

The talks will be held on Fridays at noon in the CNB Conference Room.

Wednesday, 12 August 2015 22:44

The IX CNB Junior Seminar Series will start on 19 September 2015 with a conference by the researcher of the University of Copenhagen Kenn Gerdes.

With the collaboration of VWR, CNB PhD students organised a series of 10 conferences by renowned scientists in the field of life sciences.

The talks will be held on Fridays at noon in the CNB Conference Room.

Wednesday, 29 July 2015 11:33

Lluis Montoliu's laboratory, in collaboration with other groups, has identified a function for sequences found in human non-coding DNA. They act as insulators, that is, they allow the transcription of genes independently of the chromosomal environment, according to the cell’s needs at any given time.

Wednesday, 22 July 2015 21:27

Plants have various mechanisms to adapt to the environment they live in. A group of scientists from the Centro Nacional de Biotecnología (CNB) recently discovered how species of the genus Solanum control the growth of new branches depending on the presence or absence of light and on plant hormones. Two different products of the BRANCHED1a gene are responsible for this.

Thursday, 09 July 2015 09:53

El investigador del CNB Pablo Gastaminza ha recibido el premio Virólogo Joven 2015 de la Sociedad Española de Virología por su brillante carrera científica. Gastaminza fue galardonado durante la celebración en Madrid del XIII Congreso Nacional de Virología.

Pablo GastaminzaGastaminza se incorporó al Centro Nacional de Biotecnología en 2010. Su laboratorio estudia los procesos celulares y moleculares que subyacen en diferentes aspectos de la biología y patogénesis del virus de la hepatitis C (VHC) con la intención de descubrir nuevas estrategias de lucha contra el virus. Recientemente describieron un factor celular, el receptor sigma-1 (S1R), como potencial diana para terapia antiviral.

Con el uso de un sistema de análisis desarrollado por ellos mismos, identificaron en su laboratorio 12 fármacos empleados en distintas enfermedades que selectivamente bloquean la entrada del virus de la hepatitis C en nuestras células. Sus artículos han sido citados en más de 2.500 ocasiones.



Monday, 29 June 2015 10:27

Durante los días 7 y 8 de octubre, la isla de la Palma acogerá la primera edición del Congreso 100xCiencia (Communicating Frontier Science). En él, los 20 centros de investigación españoles reconocidos por el programa de excelencia “Severo Ochoa” (SO) acercaremos nuestra ciencia de frontera a los medios de comunicación y al público general. También será un foro de debate sobre la comunicación y divulgación de la ciencia: mediante mesas redondas y ponencias de comunicadores y periodistas internacionales, reflexionaremos sobre las estrategias de comunicación y el impacto de la ciencia en los medios y en la sociedad.

100xCiencia100xCiencia pretende ser un lugar de encuentro entre científicos, periodistas y divulgadores. “Con este foro –explica Rafael Rebolo, presidente del Comité Organizador- queremos impulsar y crear nuevas formas de colaboración que nos permitan acercar más y mejor nuestras investigaciones a la sociedad en general y, en particular, a los más jóvenes. El futuro de una sociedad está muy ligado a la calidad de su ciencia, al trabajo y entrega de sus científicos, pero también al apoyo y los recursos que reciben. Incrementar el interés de la gente por la ciencia es esencial para lograr más apoyo. Por eso queremos y necesitamos transmitir mejor lo que hace la ciencia por todos”.

Contaremos con la presencia de una delegación invitada de reconocidos comunicadores de la ciencia y representantes de grandes medios de comunicación nacionales e internacionales que tomarán parte activa durante la celebración del evento. El programa completo se irá actualizando en las próximas semanas. La inscripción ya está abierta.

Los centros “Severo Ochoa” cubrimos prácticamente todas las áreas del conocimiento, desde astrofísica y matemáticas hasta medio ambiente y biomedicina, pasando por las humanidades. El foro ofrecerá una visión completa de la investigación de frontera que se realiza en España, con ponencias divulgativas en las que representantes de cada centro presentarán a los periodistas los nuevos resultados de investigación, así como los retos de futuro en su área de acción.

En las mesas redondas debatiremos cuestiones de interés para comunicadores y científicos, como la presencia de la ciencia en los medios de comunicación, el papel de la investigación en los grandes retos de la sociedad actual, el impacto de las acciones de divulgación y la situación de política científica en España y Europa. El congreso se complementa con actividades de divulgación dirigidas a los habitantes de La Palma.

Monday, 25 May 2015 12:12

El Centro Nacional de Biotecnología (CNB) del CSIC, acreditado como centro de excelencia Severo Ochoa, invita a catedráticos y profesores de enseñanza secundaria a participar en la primera edición del curso presencial de actualización docente La biotecnología ante los retos de la sociedad actual que se impartirá del 29 de junio al 3 de julio de 2015, en el campus de Cantoblanco, Madrid.

El curso, equivalente a 2 créditos, ha sido autorizado por la Dirección General de Mejora de la Calidad de la Enseñanza, está dirigido a profesores de Biología, Geología, Química y Tecnología, y será impartido por investigadores del CNB con amplia experiencia en comunicación científica. Tiene como objetivo contribuir a actualizar la formación de los docentes en Microbiología, Virología, Inmunología, Oncología, Genética Molecular de Plantas y Biología Molecular, Estructural y Celular.

La inscripción estará abierta hasta el 12 de junio de 2015 y se realizará por correo electrónico a la dirección . Las plazas se adjudicarán en base al orden de recepción de las solicitudes.

La información del curso puede consultarse en el sitio web de la convocatoria:


www.cnb.csic.es/~FormacionProfesorado

Thursday, 07 May 2015 12:03

Durante la sesión de hoy del simposio internacional Microbiología: TRANSMISIÓN, José Luis Martínez recibirá el Premio Fundación Lilly a una Carrera Distinguida.

Grupo de José Luis MartínezDesde 2001, el grupo del Centro Nacional de Biotecnología del CSIC dirigido por Martínez estudia los mecanismos por los que las bacterias de origen medioambiental adquieren resistencias a los antibióticos. Sus resultados han sido esenciales para comprender cómo evolucionan las bacterias durantres las infecciones crónicas.

Con su investigación analiza el papel que juegan los ecosistemas naturales en la adquisición y la evolución de la resistencia a los antibióticos. Aunque los antibióticos se empezaron a usar como medicamentos en los años 40, Martínez explica que la adquisición de resitencia a ellos por parte de las bacterias "es el resultado de millones de años de evolución en ecosistemas naturales no clínicos".

Su trabajo aporta información para la búsqueda de nuevos fármacos que puedan ayudar a reducir la resistencia a los antibióticos. Entre las dianas terapéuticas que ha encontrado, actualmente centra sus estudios en un sistema de bombeo múltiple de drogas presente en todos los seres vivos y que contribuye tanto a la resistencia a la quimioterapia como a los antibióticos. Su grupo encontró recientemenet que la expresión de la bomba SmeDEF de Stenotrophomonas maltophilia se iniciada en presencia del biocida triclosa, suguiriendo que los biocidas que usamos habitualmente podrían llegar a seleccionar microrganismos resistentes a los antibióticos.

Tuesday, 28 April 2015 09:51

The Centro Nacional de Biotecnología (CNB-CSIC) is organising its 3rd Course on Introduction to Research for students in the final years of any university degree in science. The course is designed for qualified, highly motivated students who would like to contact the scientists at the CNB. The goal of this course is to provide an overview of the centre’s cutting-edge research facilities.

3rd CNB Course on Introduction to ResearchThe four-week course will be held on 6 – 31 July 2015. Up to 12 selected students will be registered free of charge.

For four weeks, the students will participate in the scientific activities of two research departments of their choice (2 weeks each), attend seminars on hot topics in today’s life sciences, and meet and talk with CNB scientists. Candidates are counselled to visit our website to learn about our projects and interests.

The completed application (doc/odt/pdf) form must be received before 29 May 2015, by e-mail to Alfonso Mora or by post to the Centro Nacional de Biotecnología (2nd Course on Introduction to Research), c/ Darwin #3, 28049 Madrid, Spain.






















Monday, 20 April 2015 10:29

Women for Africa Foundation is launching a call for applications to the programme Science by Women, aimed at selecting 2 senior African women scientists to be integrated for 6 months in the Spanish Centro Nacional de Biotecnología (CNB-CSIC) in the following areas: health, agriculture and food security, water, energy and climatic change.

Mujeres por ÁfricaThe programme´s ultimate goal is to enable African women researchers to play a leading role in the transition of Africa to a knowledge-based and innovation-led economy.

Deadline for proposal submission: 15 June 2015

Applications will be subjected to a rigorous selection process, evaluating the scientific merits and leadership of the applicants as well as the scientific quality and expected impact of their research projects. Selected candidates will receive training and integration in a dynamic, multidisciplinary and highly competitive working team, where they will be able to develop their research projects and acquire complementary skills, empowering them to transfer their research results into tangible economic and social benefits.

more information

Thursday, 26 March 2015 09:24

Angiogenesis, the formation of new vessels from pre-existing ones, is essential to provide oxygen and nutrients to damaged and proliferating tissues.

AngiobodiesTumor vessels have multiple structural and functional abnormalities compared to normal blood vessels. They are not well organized, show unusual leakiness, and are poorly functional contributing to increased tissue hypoxia. Since angiogenesis was proposed as a new target to ‘starve’ tumor cells, a greater understanding has achieved about the complexity of the cellular components and molecular pathways involved in tumor angiogenesis.


However, open questions and new challenges remain including inhibition versus normalization of the tumor vasculature, selective targeting of endothelial cells or other cellular players such as inflammatory cells, novel targets that could avoid tumor cell scape strategies to anti-angiogenic therapies, etc. Advances in new methodologies for the engineering and production of human recombinant antibodies are making it possible to image the tumor blood vessels and to provide new opportunities for delivering and targeting bioactive molecules and cellular subsets in the tumor vasculature in a selective and efficient way


In this event, which will be held in Madrid this coming June, experts from international research institutes will review the current concept of targeting tumor blood vessels, the potential of antibody-based therapies, and will try to identify future challenges in the field through an interdisciplinary approach.








PROGRAMME

Angiobodies
Tuesday, 24 March 2015 08:08

Un grupo del Centro Nacional de Biotecnología del CSIC (CNB), en colaboración con investigadores del Instituto Max-Planck de Golm (Alemania) y de la Fundación Noble (USA) han descubierto que una proporción importante de los RNAs mensajeros de una planta se mueven entre distintos órganos. De hecho, se estima que más del 25% (8000) de los RNAs mensajeros son móviles.

ArabidopsisPara demostrarlo los investigadores han utilizado una estrategia basada en la obtención de injertos entre ecotipos de plantas que muestran suficientes diferencias de secuencia de sus RNAs como para poder detectar la presencia de RNAs móviles que atraviesan el sitio del injerto en la planta receptora. Esta investigación se publica en el último número de la revista Nature Plants. Javier Paz-Ares, co-director del estudio junto con Fritz Kragler (Alemania) y Wolf Scheible (EE.UU.), explica que aunque la actividad de los RNAs mensajeros se ha asociado tradicionalmente al sitio donde se sintetizan, se conocían un pequeño número de excepciones de RNAs que se mueven. “Lo que constatamos en nuestro trabajo y en otro reciente de otro grupo es que el movimiento de RNAs es más una de las reglas que la excepción”.

Independientemente de su interés intrínseco, estos resultados suscitan más preguntas que las que contestan. En concreto, ¿Cuál es el significado biológico de estos resultados? ¿Para qué se mueven los RNAs? ¿Tienen los RNAs funciones distintas en el sitio de síntesis que en el lugar al que se mueven? ¿Cómo se regula el movimiento de RNAs?

En otro orden de cosas, los resultados, explica Paz-Ares, demuestran que hay movimiento de material con información genética hereditaria a través de injertos de plantas y los injertos de plantas se utilizan por el hombre desde la antigüedad; se considera que los injertos entre especies vegetales ya se utilizaban en la civilización china hace 4000 años. Por ello, llevamos mucho tiempo comiendo frutas con RNAs que en buena lid no les pertenecen. Dado que no se tiene ninguna evidencia de que tal práctica haya supuesto ningún peligro para la especie humana o para el ecosistema, cabría preguntarse si están justificadas la posiciones tan contrarias por una buena parte de la sociedad a la utilización de organismos modificados genéticamente con genes de especies relacionadas o si se puede sosegar el debate, concluye Paz-Ares.

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