Embryonic development and differentiation in vertebrates

JJSanz

 

Juan José Sanz-Ezquerro

Group Leader

Contact

 

Research summary

Our group is interested in the study of the molecular and cellular mechanisms that govern embryonic development in vertebrates. During organ formation in the embryo there is a genetic control of cellular behaviours such that cells proliferate, differentiate, migrate and get organised properly at the correct place and time.

 

Publications

Alsina‐Beauchamp D, Escós A, Fajardo P, González‐Romero D, E Díaz‐Mora, Risco A, Martín‐Serrano MA, del Fresno C, Dominguez‐Andrés J, Aparicio N, Zur R, Shpiro N, Brown GD, Ardavín C, Netea MG, Alemany S, Sanz‐Ezquerro JJ, Cuenda A. Myeloid cell deficiency of p38γ/p38δ protects against candidiasis and regulates antifungal immunity. EMBO Mol Med 2018; e8485; DOI 10.15252/emmm.201708485

Cuenda A, Sanz-Ezquerro JJ. p38γ and p38δ: From Spectators to Key Physiological Players.Trends Biochem Sci. 2017 Jun;42(6):431-442

Uribe V, Badia-Careaga C, Casanova JC, Domínguez JN, de la Pompa JL, Sanz-Ezquerro JJ. Arid3b is essential for second heart field cell deployment and heart patterning. Development 2014; 141:4168-4181

 

Fig1SanzOur group is interested in understanding the molecular and cellular basis of organ formation during embryonic development. This knowledge is important for identifying the origin of congenital malformations and for the design of therapies for human diseases with alterations in developmental genes and signalling pathways. We study heart and digit formation in animal models (mouse and chicken). We have made the following recent contributions.

The tip of digits is a structure characterised by specific gene expression

Formation of the last phalanx of the digits occurs by a special mechanism, different from that of proximal phalanges. We showed that Sp8 and Bambi are expressed in the digit tips and that this expression can be used to distinguish a true tip from that in a truncated digit (Casanova 2012). We also found that application of Fgf8 to digit primordia can elongate digits in some but not all cases, which suggests different digit morphogenesis programmes. Characterisation of these specific mechanisms could lead to understanding of the evolution of limbs, one of the most diversified anatomical structures. The study of these mechanisms is also important for understanding the unique capacity of digit tips to regenerate, which could have biomedical applications. We will continue this research line, analysing the regenerative capacity of digits in animals with a reduced inflammatory response, to study the relationship between regeneration and inflammation.

The gene Arid3b is necessary for heart development

Arid3b is a transcription factor whose functions are poorly characterised. We determined that Arid3b is expressed in the primitive heart and that it is necessary for heart development (Uribe 2014). Arid3b-deficient embryos die early in development due to defects in the addition of cardiac progenitors to the heart tube. Arid3b appears to control cell motility and expression of cardiac factors, at least through the regulation of other genes such as Lims2 and Bhlhb2. This result extends our knowledge of Arid3b during embryo development, suggesting a general role in cell movement, and possible involvement in cancer.

 

Fig2SanzRed

 

grupoSanz

 

Name
Position
Contact
Juan José Sanz-Ezquerro Principal investigator
Marta Pacheco Master Student
Jose Maria Ballestero Master Student
Ana Barettino Master Student

NOTE! This site uses cookies and similar technologies.

If you continue browsing or do not change browser settings, we consider your acepptance for using. Learn more

I understand

COOKIES POLICY

A cookie is a text file that is stored on your computer or mobile device via a web server and only that server will be able to retrieve or read the contents of the cookie and allow the Web site remember browser preferences and navigate efficiently. Cookies make the interaction between the user and the website faster and easier.

General information

This Website uses cookies. Cookies are small text files generated by the web pages you visit, which contain the session data that can be useful later in the website. In this way this Web remembers information about your visit, which can facilitate your next visit and make the website more useful.

How do cookies?

Cookies can only store text, usually always anonymous and encrypted. No personal information is ever stored in a cookie, or can be associated with identified or identifiable person.

The data allow this website to keep your information between the pages, and also to discuss how to interact with the website. Cookies are safe because they can only store information that is put there by the browser, which is information the user entered in the browser or included in the page request. You can not run the code and can not be used to access your computer. If a website encrypts cookie data, only the website can read the information.

What types of cookies used?

The cookies used by this website can be distinguished by the following criteria:

1. Types of cookies as the entity that manages:

Depending on who the entity operating the computer or domain where cookies are sent and treat the data obtained, we can distinguish:

- Own cookies: are those that are sent to the user's terminal equipment from a computer or domain managed by the editor itself and from which provides the service requested by the user.

- Third party cookies: these are those that are sent to the user's terminal equipment from a machine or domain that is not managed by the publisher, but by another entity data is obtained through cookies.

In the event that the cookies are installed from a computer or domain managed by the editor itself but the information collected by these is managed by a third party can not be considered as party cookies.

2. Types of cookies as the length of time that remain active:

Depending on the length of time that remain active in the terminal equipment can be distinguished:

- Session cookies: cookies are a type designed to collect and store data while the user accesses a web page. Are usually used to store information that only worth preserving for the service requested by the user at any one time (eg a list of products purchased).

- Persistent cookies: cookies are a type of data which are stored in the terminal and can be accessed and treated for a period defined by the head of the cookie, and can range from a few minutes to several years.

3. Cookies types according to their purpose:

Depending on the purpose for which the data are processed through cookies, we can distinguish between:

- Technical cookies: these are those that allow the user to navigate through a web page or application platform and the use of different options or services it exist as, for example, control traffic and data communication, identify the session, access to restricted access parts, remember the elements of an order, make the buying process an order, make an application for registration or participation in an event, use security features while browsing store content for dissemination videos or sound or share content via social networks.

- Customization cookies: these are those that allow the user to access the service with some general characteristics based on a predefined set of criteria in the user terminal would eg language, the type of browser through which you access the service, the locale from which you access the service, etc.

- Analysis cookies: they are those that allow the responsible for them, monitoring and analyzing the behavior of users of the web sites that are linked. The information gathered through such cookies are used in measuring the activity of web sites, application or platform and for the profiling of user navigation of such sites, applications and platforms, in order to make improvements function data analysis how users use the service.

Management tool cookies

This Website uses Google Analytics.

Google Analytics is a free tool from Google that primarily allows website owners know how users interact with your website. Also, enable cookies in the domain of the site in which you are and uses a set of cookies called "__utma" and "__utmz" to collect information anonymously and reporting of website trends without identifying individual users..

For statistics of use of this website use cookies in order to know the level of recurrence of our visitors and more interesting content. This way we can concentrate our efforts on improving the most visited areas and make the user more easily find what they are looking for. On this site you can use the information from your visit for statistical evaluations and calculations anonymous data and to ensure the continuity of service or to make improvements to their websites. For more details, see the link below privacy policy [http://www.google.com/intl/en/policies/privacy/]

How to manage cookies on your computer: disabling and deleting cookies

All Internet browsers allow you to limit the behavior of a cookie or disable cookies within settings or browser settings. The steps for doing so are different for each browser, you can find instructions in the help menu of your browser.

If you decline the use of cookies, since it is possible thanks to the preferences menu of your browser or settings, reject, this website will continue to function properly without the use of the same.

Can you allow, block or delete cookies installed on your computer by setting your browser options installed on your computer:

- For more information about Internet Explorer click here.
- For more information on Chrome click here.
- For more information about Safari click here.
- For more information about Firefox click here.

Through your browser, you can also view the cookies that are on your computer, and delete them as you see fit. Cookies are text files, you can open and read the contents. The data within them is almost always encrypted with a numeric key corresponding to an Internet session so often has no meaning beyond the website who wrote it.

Informed consent

The use of this website on the other hand, implies that you paid your specific consent to the use of cookies, on the terms and conditions provided in this Cookies Policy, without prejudice to the measures of deactivation and removal of cookies that you can take, and mentioned in the previous section.