Nanomedicine, Cancer Immunotherpy and Autoimmune diseases

DBarber

 

Domingo F. Baber

Group Leader

Contact

 

Research summary

The overall objective of the group is to develop new nanoparticle-based nanomedicines that allow efficient, specific targeting of drugs, biomolecules or cell types to the desired site of action in anti-tumour and immunosuppressive therapies.

 

Publications

Rojas JM, Sanz-Ortega L, Mulens-Arias V, Gutiérrez L, Pérez-Yagüe S, Barber DF. Superparamagnetic iron oxide nanoparticle uptake alters M2 macrophage phenotype, iron metabolism, migration and invasion. Nanomedicine. 2016 May;12(4):1127-38. doi: 10.1016/j.nano.2015.11.020.

Mulens-Arias V, Rojas JM, Pérez-Yagüe S, Morales MP, Barber DF. Polyethylenimine-coated SPION exhibits potential intrinsic anti-metastatic properties inhibiting migration and invasion of pancreatic tumor cells. J Control Release. 2015 Oct 28;216:78-92. doi: 10.1016/j.jconrel.2015.08.009

Spada R, Rojas JM, Barber DF. Recent findings on the role of natural killer cells in the pathogenesis of systemic lupus erythematosus. J Leukoc Biol. 2015 Oct;98(4):479-87. doi: 10.1189/jlb.4RU0315-081RR.

Mulens-Arias V, Rojas JM, Pérez-Yagüe S, Morales MP, Barber DF. Polyethylenimine-coated SPIONs trigger macrophage activation through TLR-4 signaling and ROS production and modulate podosome dynamics. Biomaterials. 2015 Jun;52:494-506. doi: 10.1016/j.biomaterials.2015.02.068.

Spada R, Rojas JM, Pérez-Yagüe S, Mulens V, Cannata-Ortiz P, Bragado R, Barber DF. NKG2D ligand overexpression in lupus nephritis correlates with increased NK cell activity and differentiation in kidneys but not in the periphery. J Leukoc Biol. 2015 Mar;97(3):583-98. doi: 10.1189/jlb.4A0714-326R.

 

figura3BarberBesides its physiological functions –identifying and eliminating harmful pathogens without harming the tissues and organs themselves— the immune system can be manipulated specifically for therapeutic purposes by active immunization, immunotherapy or immunomodulation. We refer to immunosuppressive immunotherapy when the objective is to reduce or suppress the body’s immune response, as in the case of autoimmune diseases, and immunostimulatory immunotherapy when the objective is to elicit or amplify the natural immune response, as in the case of antitumor immunotherapy. Immunosuppressors or immunostimulants, including biomolecules and drugs, are already used to prevent and to treat numerous diseases. Their use is generally limited, however, due to the systemic toxicity they can produce. Traditional cancer treatments can likewise generate numerous side effects due to their systemic toxicity.

Our group considers that the use of nanoparticle-based nanomedicines in immunosuppressive or anti-tumour therapies will improve the effectiveness of existing therapies. It would permit the release of drugs or biomolecules specifically at the site of action, which could achieve high local concentrations, as the nanoparticles can be guided and focused on the area of interest by an external magnetic field and/or by functionalization, while maintaining low systemic concentrations that would reduce the undesirable side effects of current therapies. The combination of nanoparticles and immunomodulation seems a very attractive idea.

 

figura4Barber

 grupoBarberRed 

Name
Position
Contact
Domingo F. Barber Principal investigator
Patricia Hernández Flores Predoctoral scientist
Laura Sanz Ortega Predoctoral scientist
Yadileiny Portilla Tundidor Predoctoral scientist
Sonia Pérez-Yagüe Technician
José Luis Tajada Herráiz Technology Advisor

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