Identificado el mecanismo que emplea el virus de la gripe para provocar daño cardíaco
- El trabajo liderado por el CNB-CSIC muestra que la infección y replicación del virus en el corazón produce un fallo en la transmisión del impulso eléctrico cardiaco
- Un virus de la gripe más patogénico que otro atenuado permanece más tiempo en el corazón, de ahí que sea importante la detección temprana en pacientes con enfermedad cardíaca aguda
Un trabajo liderado por investigadores del Consejo Superior de Investigaciones Científicas (CSIC) y el Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES) ha descrito la fisiopatología cardíaca asociada a la infección por el virus de la gripe (especialmente en un virus muy patogénico en humanos), que puede derivar en muerte prematura. Los investigadores han mostrado que la infección y replicación del virus en el corazón produce un fallo en la transmisión del impulso eléctrico cardiaco, que puede desembocar en la muerte. Los resultados, publicados en Cardiovascular Research, destacan la potencial relevancia de la detección temprana del virus de la gripe en casos clínicos con daño cardíaco agudo durante las temporadas o brotes de gripe.
El trabajo, fruto de la colaboración con el Centro Nacional de Investigaciones Cardiovasculares (CNIC), el Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV) y el Hospital Clínico San Carlos, ha evaluado los mecanismos relacionados con el daño cardiaco en la infección por el virus de la gripe in vivo en un modelo de ratón y en células musculares cardíacas derivadas de células humanas pluripotentes.
La galerista Helga de Alvear apoya con un millón de euros el trabajo del equipo del virólogo Luis Enjuanes en la investigación del Covid-19
A newly identified protein in Salmonella explains relapses following cephalosporin treatment
Identification of an organelle associated with microtubules in the plant vacuolar trafficking pathway
El CNB-CSIC acoge el criomicroscopio electrónico más avanzado de España
DGK ζ is key for the cellular flexibility of B lymphocytes to capture antigens
- Diacylglycerol kinases regulate the immune response mediated by B and T lymphocytes.
- The isoform DGK ζ is essential for the reorganization of the B cell cytoskeleton during the process of antigen capture, which is needed for antibody production and generation of memory cells that confer long-term immunity.
DGK (diacylglycerol kinases) are proteins known for their role as negative regulators of the immune response of B and T lymphocytes. For this reason, they are under study as therapeutic targets for the treatment of pathologies as cancer, pursuing to boost the immune response through their inhibition.
A study performed by Yolanda R. Carrasco´s group at the National Center of Biotechnology (CNB-CSIC) has revealed that the ζ isoform of the DGK also acts as a positive regulator of the B lymphocyte response. The results, recently published in Science Signaling, derive from a collaborative effort with the groups of Isabel Mérida at CNB-CSIC, Balbino Alarcón at CBMSO-CSIC-UAM and two groups of biophysics expertise leaded by Paolo Pierobon and Julien Husson at Institut Curie and Ecole Polytechnique in Paris, respectively.
Secuencias de A-tracts regulan el plegamiento del genoma mediante cambios en su flexibilidad
- Secuencias de A-tracts regulan el plegamiento del ADN en el núcleo de la célula
- La cantidad y la distribución de secuencias A-tracts determinan la flexibilidad del ADN
- Tecnologías de molécula única como la microscopía de fuerzas atómicas y las pinzas ópticas y magnéticas ayudan a descifrar las bases físico-químicas del ADN
En el interior del núcleo de la célula, el genoma se encuentra meticulosamente plegado, formando una compleja estructura tridimensional. El primer paso en este plegamiento es la formación de nucleosomas. Numerosos estudios han revelado que la distribución de nucleosomas está directamente codificada en las propiedades biofísicas del ADN. Secuencias más flexibles tienden a formar nucleosomas más estables mientras que secuencias rígidas tienden a estar desprovistas de nucleosomas. Las secuencias A-tracts consisten en cuatro o más bases de adeninas seguidas que juegan un papel esencial en la formación de nucleosomas. El nuevo artículo del grupo de Fernando Moreno-Herrero en el Centro Nacional de Biotecnología (CNB-CSIC) publicado en la revista Nucleic Acids Research aporta información sobre como funcionan estas secuencias.
Este estudio liderado por investigadores del CNB-CSIC ha demostrado que la flexibilidad de las secuencias A-tracts está regulada por el número y su distribución a lo largo del genoma. Moreno-Herrero, investigador principal del trabajo destaca: “hasta ahora se conocía la estructura y propiedades mecánicas de una secuencia A-tract aislada, sin embargo, se desconocía el efecto colectivo que su distribución podía tener en el plegamiento del ADN”. Alberto Marín-González, primer autor del trabajo indica: “hemos descubierto que la distribución periódica de secuencias A-tracts inducen un plegamiento en el ADN afectando su flexibilidad y esto explicaría los diferentes grados de afinidad de estas secuencias con los nucleosomas”.
Prion transmission is an evolutionary conserved mechanism
El CSIC recibe 350.000 euros del Grupo Catalana Occidente para contribuir a lograr una vacuna contra el SARS-CoV2
- La dotación financiará los proyectos del CNB-CSIC que buscan un candidato a vacuna para abordar la epidemia de Covid19 a través de la Fundación Jesús Serra.
El Consejo Superior de Investigaciones Científicas (CSIC) ha recibido 350.000 euros del Grupo Catalana Occidente, a través de su Fundación Jesús Serra, para potenciar los proyectos de investigación que buscan una vacuna contra el coronavirus SARS-CoV-2 que pueda proteger a la población frente a la infección.
La aportación está destinada a los grupos de investigación del Centro Nacional de Biotecnología (CNB-CSIC), que desde enero están liderando, en colaboración con otros grupos de investigación nacionales e internacionales, varios proyectos para conocer en detalle la estructura de este coronavirus, y abordar el desarrollo de candidatos a vacunas mediante edición genética.
El CNB recibe 180.000 euros de Club Madrid, con el apoyo de Kingold Group, para investigar la Covid-19
- El CNB-CSIC destinará la donación a financiar la contratación de personal y la adquisición de materiales de investigación
El Centro Nacional de Biotecnología (CNB-CSIC) del Consejo Superior de Investigaciones Científicas (CSIC) ha recibido 180.000 euros de la institución sin ánimo de lucro World Leadership Alliance-Club de Madrid, con el apoyo de Kingold Group, para impulsar las investigaciones en marcha sobre el coronavirus SARS-CoV-2, causante de la pandemia de Covid19. La donación irá destinada a contratar personal y material de investigación.
La presidenta del CSIC, Rosa Menéndez, ha agradecido la donación de Club Madrid porque “contribuirá a apoyar el avance de las líneas de investigación punteras del CNB-CSIC que estudian los coronavirus y que están trabajando en cooperación internacional para abordar la epidemia”.
El director del CNB-CSIC, Mario Mellado, ha destacado: “esta donación supone un fuerte impulso para los equipos del CNB-CSIC que están inmersos en el desarrollo de tratamientos y vacunas eficaces en este nuevo reto al que nos enfrentamos”.
La secretaria general de World Leadership Alliance-Club de Madrid, María Elena Agüero, señala: “ante la pandemia Covid19, Club de Madrid ha apostado por apoyar la ciencia y realizar una donación económica al CSIC para promover la investigación sobre el SARS-CoV-2 que permita la contratación de personal especializado y la adquisición de material y reactivos para el avance de las investigaciones sobre el coronavirus”.
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