DDA1 gene for mitigating negative ABA effects on growth during abiotic stress. Improved germination, seedling establishment, root growth and enhanced crop growth under stress conditions

Dr Vicente Rubio’s research group found that PYL8, a receptor for the water-stress hormone ABA, is specifically targeted for ubiquitin-mediated degradation by DDA1 protein, which previously had no known function.  The inventors showed that DDA1 binds to PYL8 in vivo and mediates its degradation through the proteasome, and that DDA1 overexpression in transgenic plants reduces plant sensitivity to ABA.  The commonly observed ABA repression of seed germination, seedling establishment and root growth is much reduced in DDA1-overexpressing plants.  These plants are also less sensitive to NaCl- or mannitol-mediated inhibition of seed germination compared to wild type. DDA1 is highly conserved in vascular plants, including all important crop species.


Research Group: Dr Vicente Rubio

Application Number and priority date: European patent application EP13382197.5, 29/05/2013

International PCT Application: PCT/EP2014/061214, 29/05/2014 (published as WO/2014/191539)

Present situation: Exclusive license agreement to Plant Bioscience Limited (PBL) (11/01/2013) but sublicensing rights are available from PBL

Reference: Irigoyen et al. Targeted degradation of abscisic acid receptor PYL8 is mediated by ubiquitin ligase substrate adaptor DDA1 in Arabidopsis. Plant Cell 2014; 26:712-28

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