CSIC and the University of Las Palmas de Gran Canaria have developed a panel of high affinity nanobodies (Nb) binding to diverse SARS-CoV-2 RBD epitopes of spike protein, and a set of nanobody- derived neutralizing heavy chain antibodies (hcAbs) with therapeutic potential in vivo, as they can protect hACE2-transgenic mice after infection with a lethal dose of SARS-CoV-2.
Industrial partners from biotech pharmaceutical industry are being sought to collaborate through a patent licence or co-development agreement
An offer for Patent Licensing or co-development
More information here
CSIC and Universidad Autónoma de Madrid (UAM) have characterized new structures in the peptidoglycan of pathogenic bacteria like Salmonella isolated from the intracellular niche of mammalian cells. Some of the structural differences that have been characterized attain for modifications in the D Ala residue of stem peptides that affect their inflammatory potential.
Industrial partners from the ophthalmic or pharmaceutical industry are being sought to collaborate through a patent licence agreement.
An offer for Patent Licensing
More information here
CSIC have found that coated iron oxide (IONPs) and iron oxyhydroxide nanoparticles (IOHNPs) can be used in the treatment and prevention of viral infections caused by Coronaviridae, especially those caused by respiratory syndrome-related coronaviruses selected from the species “Severe acute respiratory syndrome-related coronavirus” (such as SARS-CoV and SARS-CoV-2) and “Middle East respiratory syndrome-related coronavirus” (MERS-CoV). These coated nanoparticles can provide protection against coronaviruses and represent a new treatment for COVID-19 disease.
Industrial partners from the pharmaceutical industry are being sought to collaborate through a patent licence agreement.
More information here
CSIC has developed ENGAGE, engineered bacteria with cell adhesion specificity and programmed delivery of therapeutic proteins into the cytoplasm of target mammalian cells
Industrial partners from the ophthalmic or pharmaceutical industry are being sought to collaborate through a patent licence agreement.
More information here
CSIC has developed a procedure for capturing atmospheric CO2 into sugars by constructing and using a recombinant Synechococcus elongatus strain. The novel strain is able to overproduce sucrose coupled to growth in the absent of any environmental stress. Furthermore, the strain is able to maintain a very high sucrose production rate for a long time while exceeding titers previous reported by engineered cyanobacteria. The organic sugar produced can be further used for feeding any biotechnological process in the context of autotrophic/heterotrophic microbial consortia.
Industrial partners are being sought to collaborate through a patent licence agreement.
More information here
CSIC has discovered a new use for an existing drug on the market as antiviral agent
A new use for a drug already on the market: the prevention or/and treatment of COVID-19
These days there is a need for safe and effective antiviral agents with a wide spectrum of anti-viral activity. Since the emergence of a novel coronavirus (SARS-CoV-2) from Wuhan, China, in December 2019, that has caused millions of cases of human infections and huge cases of deaths globally and was declared as a pandemic by World Health Organisation, broad-spectrum antivirals for the treatment of emerging and endemic CoVs are needed. The virus spreads rapidly from the transmission among human, and the symptoms caused by the virus (abbreviated “COVID-19”) ranges from mild cough and fever to severe pneumonia and potentially life-threatening symptoms. Waiting for the availability of new vaccines, this global emergency has triggered the search for safe and effective pharmacological approaches for eradicating the virus, or at least reducing its effects and hindering the contagion, since, currently there is only one approved therapy to treat SARS-CoV-2 infection. By using a computational approach, the library of FDA approved drugs, already used in humans, has been screened to identify in a quick and efficient way potential antiviral agents against SARS-CoV-2 to be subsequently studied in the corresponding biological studies. In this way, a promising candidate has been found.
More information here
Researchers at the CNB and the Polytechnical University of Valencia have jointly developed an expression vector system that provides a flexible framework for plant biotechnology and synthetic biology applications. The system includes novel mini binary vectors with compatible origins. Vectors have been used successfully in plant transient and stable expressions, CRISPR/Cas9-targeted genome mutagenesis, and for genetic circuit component and viral expression vector delivery.
More information here
Dr Victor de Lorenzo’s group is developing KT2440 strains of robust stress-resistant and safe (GRAS certified) Pseudomonas putida that are able to utilise plant biomass-derived sugars – glucose, cellobiose, and xylose – and convert them into valuable bioplastics, polyhydroxyalkanoates (PHA) and the platform chemical xylonate. Xylonate can be used as a complexing agent, chelator, or a precursor for co-polyamides, polyesters, hydrogels, 1,2,4-butanetriol, ethylene glycol or glycolate, and may also provide a cheap, non-food derived alternative for D-gluconic acid, which is widely used (about 80 kton/ year) in industry.
More information here
Drs Ana Falcón and Amelia Nieto have developed an influenza A virus that contains an amino acid change in the PB2 subunit of the viral polymerase that attenuates the virus in vivo, but replicates efficiently in cultured cells. The virus accumulates high amounts of defective viral genomes (DVGs) within its viral particles, and the content of DVGs is related with the antiviral response. Accordingly, the mutant virus elicits an efficient stimulation of the host-response, both in cell cultures and in infected mice. Mice infected with this mutant virus do not lose body weight, indicating that the virus in not pathogenic, although it replicates efficiently in the lungs.
More information here
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