- El Centro Nacional de Biotecnología (CSIC) y la Universidad Autónoma de Madrid organizan este simposio los días 12 y 13 de junio
- Una treintena de prestigiosos expertos repasan el estado actual de la criomicroscopía electrónica a través de su experiencia investigadora y la aplicación de la técnica en diferentes campos
Los días 12 y 13 de junio se celebra el simposio 25 años de criomicroscopía electrónica en España. Un homenaje a José L. Carrascosa en el campus de la Universidad Autónoma de Madrid (UAM). Este simposio, enmarcado en la celebración del 50 Aniversario de la UAM, ha sido inaugurado por la presidenta del Consejo Superior de Investigaciones Científicas (CSIC), Rosa Menéndez, y por el rector de la UAM, Rafael Garesse.
Carmen Simón, researcher from the Molecualr Plant Genetics Department and director in the CSIC postgraduate Department has received the Prize for Science Dissemination awarded by the Spanish Confederation of Scientific Societies (COSCE) as a recognition of her efforts in science promotion.
The Prize committee remarked her frequent media appearances, books editions and the organisation of public engagement activities for children through the Association "Apadrina la Ciencia", where she is the current president and a founder member.
In addition, the jury highlighted her active search for contributions from individual donors, foundations and companies, which has allowed to promote doctoral theses awards, grants for emerging researchers and one-year contracts for junior researchers to complete doctoral thesis. As an example of her solidarity principles, Carmen Simón has donated the Prize compensation to Apadrina la Ciencia to generate young researchers contracts..
- The purpose of this collaboration is the fulfillment of industrial-scientific collaborations in new developments in Imaging Microscopy technology.
- This industrial-scientific partnership between CNB-CSIC and Leica Microsystems will foster the development of both parties and bring excellence to the joint endeavor.
Thanks to this agreement, the CNB Advanced Light Microscopy facility will continue to provide high-end imaging technology, tailored trainings, users´ support and fulfill best practice requirements, further evolving into the high-quality standard of worldwide recognised biological imaging centers.
This close cooperation will enable CNB and its scientific partners to learn about state-of the-art technologies in advance, whilst industry will benefit from the constant feedback experience by scientific users.
The unparalleled support of Leica Microsystems will contribute to develop a center of excellence within the Advanced Light Microscopy facility at CNB.
Fernando Almazan, researcher at CNB participates in the project COSMIC that has been awarded 3.5 Million Euro to develop systems to detect CBRNE threats in containers.
Read the full press release here
Regeneration of cardiac cells in the adult is very limited, and cardiomyocyte renewal rate is limited to around 1% per year. In other tissues, the location of stem cells reservoirs is known, but there is no consensus of where they are located in the heart after tissue damage.
Now, the data published in Redox Biology by Antonio Bernad's group describe the location of stem cells in the heart and how they evolve in response to damage and aging.
The symposium "25 years of cryoelectron microscopy in Spain: A tribute to José L. Carrascosa” will be held next 12th and 13th of June at the Autonomous University of Madrid. This symposium, included in the celebration of the 50th anniversary of the Autonomous University, will bring internationally recognised speakers such as professors Joachim Frank and Richard Henderson, awarded with the Nobel Prize in Chemistry 2017 for the development of cryoelectron microscopy.
Over two days, the current state of the art will be reviewed through the presentations of more than 30 scientists who use cryoelectron microscopy techniques in their respective research fields. In addition, these days will serve as well-deserved tribute to the CSIC research professor José L. Carrascosa, and essential promoter for the development of cryoelectron microscopy in Spain and specially at the CNB.
Inscription not required,
Full program available here
Nucleic Acid Research 2019 Apr 12019 Apr 1
Mora Gallardo C, Sánchez de Diego A, Gutiérrez Hernández J, Talavera-Gutiérrez A, Fischer T, Martínez-A C, van Wely KHM.
Abstract
Alternative splicing is facilitated by accessory proteins that guide spliceosome subunits to the primary transcript. Many of these splicing factors recognize the RNA polymerase II tail, but SFPQ is a notable exception even though essential for mammalian RNA processing. This study reveals a novel role for Dido3, one of three Dido gene products, in alternative splicing. Binding of the Dido3 amino terminus to histones and to the polymerase jaw domain was previously reported, and here we show interaction between its carboxy terminus and SFPQ. We generated a mutant that eliminates Dido3 but preserves other Dido gene products, mimicking reduced Dido3 levels in myeloid neoplasms. Dido mutation suppressed SFPQ binding to RNA and increased skipping for a large group of exons. Exons bearing recognition sequences for alternative splicing factors were nonetheless included more efficiently. Reduced SFPQ recruitment may thus account for increased skipping of SFPQ-dependent exons, but could also generate a splicing factor surplus that becomes available to competing splice sites. Taken together, our data indicate that Dido3 is an adaptor that controls SFPQ utilization in RNA splicing. Distributing splicing factor recruitment over parallel pathways provides mammals with a simple mechanism to regulate exon usage while maintaining RNA splicing efficiency.
The Centro Nacional de Biotecnología (CNB-CSIC) organises this summer the 7th Course on Introduction to Research through the CSIC JAE-Into ICUS program. These scholarships are directed to qualified and highly motivated students willing to pursue a career in science research and who would like to contact the scientists at the CNB. Students must be currently enrolled in the final year of their university degree in science (academic year 2018-2019).
New Collaboration Scholarships at Centres of Excellence Severo Ochoa and Units of Excellence María de Maeztu CSIC
This call is addressed to students enrolled or registered in an Official Master course during 2019-2020 academic year in the areas of Life Sciences, Health Science, Science, Physics, Computer Science, Biomedical or Agronomic Engineering. Each grant is allocated with 6300 euros paid in nine monthly installments. Applicants must have completed the degree in the academic year 2017/2018 or later and credit an average grade equal to or greater than 8.40.
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