Functional Proteomics

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Functional Proteomics

Fernando Corrales

Group Leader

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Publications

Calvo E, Corbacho-Alonso N, Sastre-Oliva T, Nuñez E, Baena-Galan P, et al. Why does COVID-19 affect patients with spinal cord injury milder? a case-control study: results from two observational cohorts. J Pers Med. 2020; 10(4): 182.

Adhikari S, Nice EC, Deutsch EW, Lane L, Omenn GS, et al. A high-stringency blueprint of the human proteome. Nat Commun 2020; 11(1): 5301.

Urman JM, Herranz JM, Uriarte I, Rullán M, Oyón D, González B, Fernandez-Urién I et al. Pilot multi-omic analysis of human bile from benign and malignant biliary structures: a machine-learning approach. Cancers (Basel) 2020 12 (6): 1644.

Struwe W, Emmott E, Bailey M, Sharon M, Sinz A, Corrales FJ, et al. The COVID-19 MS Coalition-accelerating diagnostics, prognostics, and treatment. COVID-19 MS Coalition. Lancet 2020; 395 (10239): 1761-1762. d

Ciordia S, Alvarez-Sola G, Rullán M, Urman JM, Ávila MA, Corrales FJ. Digging deeper into bile proteome. J Proteomics 2021; 230:103984.

Clemente LF, Hernáez ML, Ramos-Fernández A, Ligero G, Gil C, Corrales FJ, Marcilla M. Identification of the Missing Protein Hyaluronan Synthase 1 in Human Mesenchymal Stem Cells Derived from Adipose Tissue or Umbilical Cord.. J Proteome Res 2018 Jul 6. doi: 10.1021/acs.jproteome.8b00384

Mato JM, Elortza F, Lu SC, Brun V, Paradela A, Corrales FJ. Liver cancer-associated changes to the proteome: what deserves clinical focus?. Expert Rev Proteomics 2018 Sep;15(9):749-756

The Functional Proteomics laboratory of the CNB has two main research areas of interests: the study of mechanisms underlying the progression of liver diseases and the characterization of HLA peptide repertoires to define the antigen presentation principles in the context of diseases, including COVID-19.

We have developed a sample processing method that provides a three-fold increased coverage of human bile proteome (Ciordia S et al, J Proteomics, 2020). This method allowed identification of a panel of bile proteins that might prove useful for the clinical management of cholangiocarcinoma patients (Urman J et al, Cancers, 2020). We have also developed a method for liquid biopsy analysis (Navajas R et al, Methods Mol Biol 2019) that is currently being used for stratification of pre-eclampsia patients.

We coordinate a cooperative project with 25 laboratories integrating the Spanish Proteomics Platform (ProteoRed) to investigate the interaction between SARS-CoV-2 and the host cell proteome aiming to discover the bases associated to the COVID-19 progression. We also aim to discover circulating proteins with prognostic value that may lead to an efficient stratification of COVID-19 patients (Calvo E et al, J Pers Med 2020). All this work is coordinated with international initiatives, including COVID-19 MS-Coalition (Struwe W et al, Lancet, 2020) and the Human Proteome Project (Adhikari S et al Nat Comm, 2020), where we are working to define the human proteome (Omenn GS et al, J Prot Res, 2020).

Finally, we have leadership in national and international initiatives such as ProteoRed, Spanish Proteomics Society, European Proteomics Association and the Human Proteome Project. The total number of publications in 2019 and 2020 were 23. (average IF 5.52) and 14 (average IF 8.96) respectively.

Corrales 20202 Figure1

Summary of the main research areas in the CNB Functional Proteomics Laboratory

B1Grupo01Baja

Name	Position	Contact
Fernando Corrales	Principal investigator
Alberto Paradela	Senior scientist
Miguel Marcilla	Postdoctoral scientist
Lorena Carmona	Postdoctoral scientist
Rosana Navajas	Predoctoral student
Antonio Ramos	Predoctoral student
Laura Guerrero	Predoctoral student
Sergio Ciordia	Technician
Manuel Lombardía	Technician
Fátima Santos	Technician
Patricia Gómez	Technician

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