Fernando Corrales
Group Leader
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Publications
Alvarez-Sola G, Uriarte I, Latasa MU, Fernandez-Barrena MG, Urtasun R, Elizalde M, Barcena-Varela M, Jiménez M, Chang HC, Barbero R, Catalán V, Rodríguez A, Frühbeck G, Gallego-Escuredo JM, Gavaldà-Navarro A, Villarroya F, Rodriguez-Ortigosa CM, Corrales FJ, Prieto J, Berraondo P, Berasain C, Avila MA Fibroblast growth factor 15/19 (FGF15/19) protects from diet-induced hepatic steatosis: development of an FGF19-based chimeric molecule to promote fatty liver regeneration. Gut 2017;66: 66(10):1818-1828
Mora MI, Molina M, Odriozola L, Elortza F, Mato JM, Sitek B, Zhang P, He F, Latasa MU, Ávila MA, Corrales FJ Prioritizing Popular Proteins in Liver Cancer: Remodelling One-Carbon Metabolism . J Proteome Res 2017 Dec 1;16(12):4506-4514
Guruceaga E, Garin-Muga A, Prieto G, Bejarano B, Marcilla M, Marín-Vicente C, Perez-Riverol Y, Casal JI, Vizcaíno JA, Corrales FJ, Segura V Enhanced Missing Proteins Detection in NCI60 Cell Lines Using an Integrative Search Engine Approach. J Proteome Res. 2017 Dec 1;16(12):4374-4390
Clemente LF, Hernáez ML, Ramos-Fernández A, Ligero G, Gil C, Corrales FJ, Marcilla M. Identification of the Missing Protein Hyaluronan Synthase 1 in Human Mesenchymal Stem Cells Derived from Adipose Tissue or Umbilical Cord.. J Proteome Res 2018 Jul 6. doi: 10.1021/acs.jproteome.8b00384
Mato JM, Elortza F, Lu SC, Brun V, Paradela A, Corrales FJ. Liver cancer-associated changes to the proteome: what deserves clinical focus?. Expert Rev Proteomics 2018 Sep;15(9):749-756
Our main interest is the investigation of the molecular mechanisms underlying the progression of chronic liver disorders. We have identified one carbon metabolism (1CM) as an essential process to preserve the differentiated phenotype of quiescent hepatocytes. 1CM is a master connection between the intermediate metabolism and epigenetic regulation that must be finely tuned since its unbalance triggers a progressive liver ailment leading to Non Alcoholic Steatohepatitis (NASH) and Hepatocellular Carcinoma (HCC). Our work has contributed to elucidate protein networks that explain the molecular pathogenesis of chronic liver diseases and HCC using a functional proteomics approach. Deficiencies on key 1CM enzymes, such as methionine adenosyltransferase (MAT1A) and methylthioadenosine phosphorylase (MTAP) lead to a deregulated methylation capacity of liver cells and a deep reshape of their protein methylation profile (including RNA binding proteins). Assuming the key role of 1CM remodeling in the progression of liver disorders, we have developed a multiplexed mass spectrometry-based method to quantify the enzymes catalyzing 1CM reactions. This quantification kit is a straightforward method to follow up chronic liver diseased patients. All these studies are part of the Liver initiative of the Biology and Disease Human Proteome Project, which are currently coordinated by our lab. We are also actively participating in the functional annotation of unknown proteins in the framework of the Chromosome Centric Human Proteome Project. Our research has been founded with grants for more than 20 years and our results have been published in more than 140 peer reviewed scientific articles.
Functional proteomics analysis reveals changes of protein abundance and methylation that explain mechanisms of liver disease progression
