Host-pathogen interactions in obligate intracellular bacteria

LobatoD


Damián Lobato-Márquez


"Talent Attraction" researcher


Contact

 

In our group, we study how obligate intracellular bacteria manipulate the host to promote bacterial replication and how host cells respond to infection

 

Publications

Lobato-Márquez D, Conesa JJ, López-Jiménez AT, Divine ME, Pruneda JN and Mostowy S. Septins and K63 ubiquitin chains are present in separate bacterial microdomains during autophagy of entrapped Shigella. J Cell Sci, 2023, 136 (7): jcs261139.

Lobato-Márquez D, Xu J, Özbaykal-Güller G, Ojiakor A, Pilhofer M and Mostowy S. Mechanistic insight into bacterial entrapment by septin cage reconstitution. Nat Commun 2021, 12 (1): 1-14.

Krokowski S, Lobato-Márquez D, Chastanet A, Matos-Pereira P, Angelis D, Galea D, Larrouy-Maumus G, Henriques R, Spiliotis ET, Carballido-López R and Mostowy S. Septins recognize bacterial cell division for delivery to the lysosome. Cell Host Microbe 2018, 24: 866-874.

Lobato-Márquez D, Molina-García L, Moreno-Córdoba I, García-del Portillo F and Díaz-Orejas R. Stabilization of the virulence plasmid pSLT of Salmonella Typhimurium by three different maintenance systems. Front Mol Biosci 2016, 3 (66): 1-11.

Lobato-Márquez D, Moreno-Córdoba I, Figueroa V, Díaz-Orejas R and García-del Portillo F. Distinct type I and type II toxin-antitoxin modules control Salmonella lifestyle inside eukaryotic cells. Sci Rep 2015, 5: 9374.


More publications

 

 

To create an optimal replication niche, intracellular bacterial pathogens employ effector proteins to hijack host cell signalling pathways and nutrients and to counteract cell-autonomous immunity (deployed independently from specialized cells of the immune system). In my group, we study the interplay between the host and the invading pathogen, with a special focus on Rickettsia. Rickettsia includes fascinating obligate intracellular pathogens that replicate in the host cell cytosol, where bacteria can polymerise host actin for motility and cell-to-cell dissemination. Despite Rickettsia are spreading worldwide and cause life-threatening infections in humans and other mammals, the cell biology and infection process of these pathogens is poorly understood, mainly due to their genetic intractability. To address these issues, we are engineering genetic tools to promote new opportunities to study Rickettsia cell biology, including how Rickettsia effector proteins manipulate the host and how host cells control bacterial infection. Our goal is to understand what makes Rickettsia such a successful cytosolic pathogen. Considering Rickettsia is among the few bacterial pathogens that replicate in the host cell cytosol, where many cell-autonomous immune responses operate, the study of Rickettsia can provide novel insights in cell biology and immunity.



 


LobatoD Laboratory Members

Name
Position
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Damián Lobato-Márquez Talent Attraction Researcher

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