PhD offer extraordinary call PIF2024

IP: Santos Mañes

We are seeking a motivated student to join an ongoing project in our laboratory. Our research focuses on how reprogramming mitochondrial metabolism in tumor cells modifies their immunogenicity, rendering the generated tumors more susceptible to immune system activity. The selected candidate will join a team led by a young PhD to investigate: 

1. The signaling pathways linking mitochondrial metabolism rewiring with immunogenicity
2. The interaction of oncogenes (such as K-Ras) with mitochondrial metabolism, and 
3. The identification of binders of specific mitochondrial transporters

To address these questions, we will employ advanced molecular biology methods, omics analyses (bulk or single-cell RNA sequencing, ATAC-seq, quantitative proteomics…), CRISPR-based gene silencing, spectral flow cytometry, advanced imaging techniques, etc. A significant portion of the research will involve animal models, so it is advisable for the candidate to have the necessary permissions for working with animals and no ethical objections related to animal experimentation. 

Requirements:

Applicants should have completed a master’s degree in biomedicine, molecular biology, or a related field to be familiar with the topic. The training plan includes a minimum 3-month stay at an international research center, scheduled between the third and fourth year of the thesis. Therefore an appropriate level of English is mandatory.