Bacteria for cancer treatment with cell tumor-binding specificity and the ability to inject proteins into their cytoplasm with antitumor effects
A new generation of cancer therapies is emerging based on the use of engineered bacteria as vehicles capable of delivering therapeutic proteins specifically to target tumor cells. The design and incorporation of modified functional modules into a safe bacterial chassis through synthetic biology methods allow for the customized design of sophisticated new therapies.
The developed bacterial strains have shown high potential as antitumor agents. They enable the specific delivery of antitumor proteins into the cytoplasm of tumor cells through bacterial injectisomes. In addition to their demonstrated efficacy, these microorganisms ensure precise control over the expression and production of the delivery machinery, preventing failures in the administration of antitumor proteins.
