Standard European Vector Architecture

The  SEVA platform is a web-based resource and a material clone repository to assist the choice of optimal plasmid vectors for de-constructing and re-constructing complex prokaryotic phenotypes based in the SEVA database (SEVA-DV), originally launched in 2013.

The updated SEVA database 4.0 (SEVA-DB 4.0) is a resource for implementation of a standard for physical assembly of vector plasmids and for their non-ambiguous nomenclature as well as the index for a repository of functional sequences and actual constructs available to the community. The database was designed to simplify the choice of a given vector for the sake of specific applications, in such a way the user can easily decide the best configuration of replication origins, antibiotic resistance and business segments.

The SEVA-DB adopts simple design concepts imported from Systems Engineering into vector architecture and development to facilitate the swapping of functional modules and the extension genome engineering options to microorganisms beyond typical Laboratory strains. This platform has been implemented in the Molecular Environmental Microbiology Laboratory (CNB-CSIC).

Since their launching in 2013, the SEVA platform has sent over 3700 plasmids to more than 43 countries.

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