IP: Juan Nogales
PRE or POST DOCTORAL CONTRACT available at the National Centre for Biotechnology (CNB-CSIC), Madrid (Spain).
Project: Enhancing Production of High Value Pharmacological Metabolites Using Synthetic Biology.
Description of Work
The research project aims to design a robust process to enhance the productivity of polyketide and non ribosomal peptide (PK/compounds with antitumor and antiviral properties using a DBTL ( Build, Test, and Learn) workflow .
The main tasks include the heterologous expression of target metabolic pathways and their subsequent performance optimization through advanced synthetic biology approaches in Pseudomonas putida. The project will leverage combinatorial pathway assembly and AI/ML driven host optimization
The candidate will carry out a competitive research project in the field of Systems Metabolic Engineering under Synthetic Biology framework. Predoctoral and postdoctoral researchers are encouraged to apply.
Requirements
– MS or PhD in Molecular Biology, Synthetic Biology, Biotechnology or similar
– Experience in bacterial physiology and metabolism, knowledge of molecular biology and bioinformatics will be highly valued
This is a 3 year contract Salary will be based on experience, following CSIC standards
Key words: Systems Biology Synthetic Biology DBTL optimization Pseudomonas putida PK/NRP production, Evolutionary Engineering
Deadline: 20th January 2025
Contact and more information Dr. Juan Nogales Enrique
Related publications
MT Manoli , et al., 2024 ) Cell Reports 43 (4)
Blazquez et al., ( 2023 ) Nucleic Acids Research 51 (19), e98 e98
T Goris et al., (2021) Microbial biotechnology 14(1), 94 110
J Nogales et al., (2020 ) Environmental microbiology 22 (1), 255 269
More information about the project (PDF)