Logic of Genomic Systems
RESEARCH GROUPS
Juan F Poyatos
Group Leader
Contact
Research Summary
Nature represents an immense library in which every aspect, every book, is full of wonders. We enjoy these wonders at all levels, but we prefer to study those that originate in systems of many interacting components. Our lab tries to identify principles in these situations. The problems we address are wide in scope and we typically approach them by employing mathematical models, analysis of available data, and the use of simple experimental setups.
Research Lines
Driving research interests:
Regulation and minimal control motifs.
The architecture of large biochemical systems.
Regulation and dysregulation of cell collectives.
Learning in natural and artificial systems
What can, and cannot, be predicted.
Publications
Recent Publications
Poyatos JF. ‘Design principles of multi-map variation in biological systems’. Phys Biol. 2024, 21(4). doi: 10.1088/1478-3975/ad5d6c.
Yubero, P, Alonso-Lavin AJ, Poyatos JF. ‘The Limitations of Phenotype Prediction in Metabolism’. PLOS Computational Biology 2023, 19 (11): e1011631 doi: 1371/journal.pcbi.1011631
Yubero P, Poyatos JF. ‘Dissecting the Fitness Costs of Complex Mutations’. Mol Biol Evol. 2021, 38(10):4520-4531 doi: 10.1093/molbev/msab193.
Alonso-Lavin AJ, Bajić D, Poyatos JF. ‘Tolerance to NADH/NAD+ imbalance anticipates aging and anti-aging interventions’. iScience 2021, 24(7):102697 doi: 1016/j.isci.2021.102697
Kovács K, Farkas Z, Bajić D, Kalapis D, Daraba A, Almási K, Kintses B, Bódi Z, Notebaart RA, Poyatos JF, et. al. ‘Suboptimal Global Transcriptional Response Increases the Harmful Effects of Loss-of-Function Mutations’. Mol Biol Evol. 2021, 38(3):1137-1150 doi: 10.1093/molbev/msaa280
Group Members
Group Leader
Juan F Poyatos
PhD candidate
Alicia Lou