LLUÍS MONTOLIU'S LABORATORY at CNB

Last Update: 2 February 2010

Some recent publications

Publications marked with PDF have corresponding PDF files available upon request by e-mail

Publications marked with PDF have corresponding PDF files available via Open Access archives

Muriilo S, Contreras J, Zurita E, Cediel R, Cantero M, Varela-Nieto I, Montoliu L (2010)

Melanin precursors prevent premature age-related and noise-induced hearing loss in albino mice

Pigment Cell and Melanoma Research 2010 Feb;23(1):72-83 (ePUB 2009 Oct 19) PDF

MEDLINE

Fielder T, Barrios L, Montoliu L (2009)

A survey to establish performance standards for the production of transgenic mice

Transgenic Research (ePUB 2009 Oct 20) PDF

MEDLINE

Phil Wilkinson; Jitka Sengerova; Raffaele Matteoni; Chao-Kung Chen; Gaetan Soulat; Abel Ureta-Vidal; Sabine Fessele; Michael Hagn; Marzia Massimi; Karen Pickford; Richard H. Butler; Susan Marschall; Ann-Marie Mallon; Amanda Pickard; Marcello Raspa; Ferdinando Scavizzi; Martin Fray; Vanessa Larrigaldie; Johan Leyritz; Ewan Birney; Glauco P. Tocchini-Valentini; Steve Brown; Yann Herault; Lluis Montoliu; Martin Hrabe de Angelis; Damian Smedley (2010)

EMMA--mouse mutant resources for the international scientific community.

Nucleic Acids Research 2010 Jan;38(Database issue):D570-6. Epub 2009 Sep 26 PDF

MEDLINE

Molto E, Fernandez A, Montoliu L (2009)

Boundaries in vertebrate genomes: different solutions to adequately insulate gene expression domains

Briefings in Functional Genomics and Proteomics 8(4):283-296 PDF

MEDLINE

Bessa J, Tena JJ, de la Calle-Mustienes E, Fernandez-Miñan A, Naranjo S, Fernandez A, Montoliu L, Akalin A, Lenhard B, Casares F, Gomez-Skarmeta JL. (2009)

Zebrafish enhancer detection (ZED) vector: A new tool to facilitate transgenesis and the functional analysis of cis-regulatory regions in zebrafish.

Developmental Dynamics 2009 Sep;238(9):2409-17 PDF

MEDLINE

Montoliu L (2009)

“Compartir”: a Spanish academic network initiative for sharing genetically modified mice

Transgenic Research  in press, epub 2009, May 26 PDF

MEDLINE

Tokimasa Hida, Kazumasa Wakamatsu, Elena V. Sviderskaya, Andrew J. Donkin, Lluis Montoliu, M. Lynn Lamoreux, Bin Yu, Glenn L. Millhauser, Shosuke Ito, Gregory S. Barsh, Kowichi Jimbow and Dorothy C. Bennett (2009)

Agouti protein, mahogunin and attractin in pheomelanogenesis and melanoblast-like alteration of melanocytes: a cAMP-independent pathway

Pigment Cell and Melanoma Research 22: 623-634  PDF

MEDLINE

Montoliu L, Roy R, Regales L, Garcia-Diaz A (2009)

Design of vectors for transgene expression: The use of genomic comparative approaches

Comparative Immunology, Microbiology and Infectious Diseases 32: 81-90 PDF

MEDLINE

Murray JD, Whitelaw B, Montoliu L. (2007)

Meeting Report: UC Davis Transgenic Animal Research Conference VI : Granlibakken Conference Center, Tahoe City, California, August 12-16, 2007.

Transgenic Res. 16(6):835-7;  PDF

MEDLINE

Victoria V. Lunyak, Gratien G. Prefontaine, Esperanza Nuñez, Thorsten Cramer, Bong-Gun Ju, Kenneth A. Ohgi, Kasey Hutt, Rosa Roy, Angel Garcia-Diaz, Xiaoyan Zhu, Yun Yung, Lluis Montoliu, Christopher K. Glass, Michael G. Rosenfeld (2007)
Developmentally Regulated Activation of a SINE B2 Repeat as a Domain Boundary in Organogenesis
Science 317:248-51 PDF
MEDLINE
CSIC Press release
Faculty of 1000 Biology (comment)
Comment (Research Roundup) in Journal of Cell Biology (30 July 2007)

Moreira P.N., Pozueta J., Perez-Crespo M., Valdivieso F., Gutierrez-Adan A., Montoliu L. (2007)
Improving the generation of genomic-type transgenic mice by ICSI
Transgenic Research 16(2):163-8 PDF
MEDLINE

Moreira PN, Perez-Crespo M, Ramirez MA, Pozueta J, Montoliu L, Gutierrez-Adan A. (2007)
Effect of Transgene Concentration, Flanking Matrix Attachment Regions, and RecA-Coating on the Efficiency of Mouse Transgenesis Mediated by Intracytoplasmic Sperm Injection.
Biology of Reproduction 76(2):336-43 PDF
MEDLINE

Moreira P.N., Pozueta J., Giraldo P., Gutiérrez-Adán A., Montoliu L. (2006)
Generation of Yeast Artificial Chromosome Transgenic Mice by Intracytoplasmic Sperm Injection
In: Methods in Molecular Biology, vol. 349; YAC Protocols: Second Edition. Ed. A. MacKenzie, Humana Press Inc., Totowa, NJ, 151-161  PDF
MEDLINE

Lavado A., Jeffery G., Tovar V., de la Villa P., Montoliu L. (2006)
Ectopic expression of tyrosine hydroxylase in the pigmented epithelium rescues the retinal abnormalities and visual function common in albinos in the absence of melanin
Journal of Neurochemistry 96(4):1201-11.  PDF
MEDLINE
Faculty of 1000 Biology (comment)
CSIC Press release

Lavado A., Montoliu L. (2006)
New animal models to study the role of tyrosinase in normal retinal development
Frontiers in Bioscience 11:743-752.  PDF
MEDLINE

Devinoy E., Montoliu L., Baranyi M., Thépot D., Hiripi L., Fontaine M.L., Bodrogi L., Bosze Z. (2005)
Analysis of the efficiency of the rabbit whey acidic protein gene 5' flanking region in controlling the expression of homologous and heterologous linked genes
Journal of Dairy Research 72(S1):113-119 PDF
MEDLINE

Lavado A., Matheu A., Serrano M., Montoliu L. (2005)
A strategy to study tyrosinase transgenes in mouse melanocytes
BMC Cell Biology  6(1):18 PDF
MEDLINE

PDF available as Open Access article at PubMed-Central

PDF available as Open Access article at Digital-CSIC

Giménez E., Lavado A., Jeffery G., Montoliu L. (2005)
Regional abnormalities in retinal development are associated with local ocular hypopigmentation
Journal of Comparative Neurology 485: 338-347. PDF
MEDLINE

Cendán C.M., Pujalte J.M., Portillo-Salido E., Montoliu L., Baeyens J.M. (2005)
Formalin-induced pain is reduced in s1 receptor knockout mice
European Journal of Pharmacology  511(1): 73-74. PDF
MEDLINE

Lavado A., Olivares C., Garcia-Borrón J.C., Montoliu L. (2005)
Molecular basis of the extreme dilution mottled mouse mutation: A combination of coding and non-coding genomic alterations
Journal of Biological Chemistry 280(6):4817-24.  PDF
MEDLINE

Montoliu L. (2004)
5th Transgenic Technology meeting (http://www.imbim.uu.se/transtech)
Transgenic Research 13: 605-606. PDF
JOURNAL

Moreira P.N., Giraldo P., Cozar P., Pozueta J., Jiménez A., Montoliu L.*, Gutiérrez-Adán A.* (2004)
Efficient generation of transgenic mice with intact yeast artificial chromosomes by ICSI
Biology of Reproduction 71(6):1943-1947. PDF
MEDLINE

Giménez E., Lavado A., Giraldo P., Cozar P., Jeffery G., Montoliu L. (2004)
A transgenic mouse model with inducible tyrosinase gene expression using the tetracycline (Tet-on) system allows regulated rescue of abnormal chiasmatic projections found in albinism
Pigment Cell Research 17(4): 363-370. PDF
MEDLINE

Montoliu L., Larue L., Beermann F. (2004)
On the Use of Regulatory Regions from Pigmentary Genes to Drive the Expression of Transgenes in Mice
Pigment Cell Research 17: 188-190. PDF
MEDLINE

Regales L., Giraldo P., García-Díaz A., Lavado A., Montoliu L. (2003)
Identification and functional validation of a 5’ upstream regulatory sequence in the human tyrosinase gene homologous to the Locus Control Region of the mouse tyrosinase gene
Pigment Cell Research 16: 685-692. PDF
MEDLINE

Langa F., Codony X., Tovar V., Lavado A., Giménez E., Cozar P., Cantero M., Dordal A., Hernández E., Pérez R., Monroy X., Zamanillo D., Guitart X., Montoliu L. (2003)
Generation and phenotypic analysis of sigma receptor type I (s1) knockout mice
European Journal of Neuroscience 18(8): 2188-2196. PDF
MEDLINE
CSIC Press release

Giménez E., Lavado A., Giraldo P., Montoliu L. (2003)
Tyrosinase gene expression is not detected in mouse brain outside the retinal pigment epithelium cells
European Journal of Neuroscience 18(9): 2673-2676. PDF
MEDLINE

Giraldo P., Martínez A., Regales L., Lavado A., García-Díaz A., Alonso A., Busturia A., Montoliu L. (2003)
Functional dissection of the mouse tyrosinase locus control region indentifies a new putative boundary activity.
Nucleic Acids Research 31(21): 6290-6305. PDF
MEDLINE
CSIC Press release

PDF available as Open Access article at PubMed-Central

Montoliu L. (2003)
Manipulating the mouse embryo: easier than ever!
Transgenic Research 12: 635-636. PDF
JOURNAL

Giraldo P., Rival-Gervier S., Houdebine L.M. & Montoliu L. (2003)
The potential benefits of insulators on heterologous constructs in transgenic animals
Transgenic Research 12: 751-755. PDF
MEDLINE

Montoliu L. (2003)
Simple databases to monitor the generation and organisation of transgenic mouse colonies
Transgenic Research 12: 251-253. PDF
MEDLINE

Millot B., Montoliu L.,  Fontaine M.L., Mata T. & Devinoy E. (2003)
Hormone induced modifications of the chromatin structure surrounding 5´ upstream regulatory regions conserved between the mouse and rabbit WAP genes.
Biochemical Journal 372(1): 41-52. PDF
MEDLINE

PDF available as Open Access article at PubMed-Central

Giraldo P. & Montoliu L. (2002)
Artificial chromosome transgenesis in pigmentary research
Pigment Cell Research 15 (4): 258-264. PDF
MEDLINE

Riu E., Mas A., Ferre T., Pujol A., Gros L., Otaegui P., Montoliu L. &  Bosch F. (2002)
Counteraction of Type 1 Diabetic Alterations by Engineering Skeletal Muscle to Produce Insulin: Insights From Transgenic Mice
Diabetes 51(3): 704-711. PDF
MEDLINE

Montoliu L. (2002)
Gene transfer strategies in animal transgenesis.
Cloning & Stem Cells 4(1): 39-46. PDF
MEDLINE

Gimenez E., Giraldo P., Jeffery G. & Montoliu L. (2001)
Variegated expression and delayed retinal pigmentation during development in transgenic mice with a deletion in the locus control region of the tyrosinase gene.
Genesis 30(1): 21-25. PDF
MEDLINE

Giraldo P. & Montoliu L. (2001)
Size matters: use of YACs, BACs and PACs in transgenic animals.
Transgenic Research10(2): 83-103. PDF
MEDLINE

Gimenez E. & Montoliu L. (2001)
A simple polymerase chain reaction assay for genotyping the retinal degeneration mutation (Pdeb^rd1) in FVB/N-derived transgenic mice.
Laboratory Animals35(2): 153-156. PDF
MEDLINE

Note: Erratum published in Laboratory Animals 35(4): 396

Rikke B.A., Simpson V.J., Montoliu L. & Johnson T.E. (2001)
No effect of albinism on sedative-hypnotic sensitivity to ethanol and anesthetics.
Alcoholism: Clinical and Experimental Research 25(2): 171-176. PDF
MEDLINE

Montoliu L., Chavez S. & Vidal M. (2000)
Variegation associated with lacZ in transgenic animals: a warning note.
Transgenic Research9(3): 237-239. PDF
MEDLINE

Giraldo P., Gimenez E. & Montoliu L. (1999)
The use of yeast artificial chromosomes in transgenic animals: expression studies of the tyrosinase gene in transgenic mice.
J.Genetic Analysis 15(3-5):175-8. PDF
MEDLINE

Gros L., Riu E., Montoliu L., Ontiveros M., Lebrigand L. & Bosch F. (1999)
Insulin production by engineered muscle cells.
Human Gene Therapy 10: 1207-1217. PDF
MEDLINE

Gros L., Montoliu L., Riu E., Lebrigand L. & Bosch F. (1997)

Jeffery G., Brem G. & Montoliu L. (1997)
Correction of retinal abnormalities found in albinism by introduction of a functional tyrosinase gene in transgenic mice and rabbits.
Developmental Brain Research 99: 95-102. PDF
MEDLINE

Montoliu L., Umland T. & Schütz G. (1996)
A locus control region at -12 kb of the tyrosinase gene.
The EMBO Journal 15: 6026-6034. PDF
MEDLINE

PDF available as Open Access article at PubMed-Central

Brem G., Besenfelder U., Aigner B., Müller M., Liebl I., Schütz G. & Montoliu L. (1996)
YAC transgenesis in farm animals: rescue of albinism in rabbits.
Molecular Reproduction and Development 44: 56-62.
MEDLINE

Schedl A., Grimes B. & Montoliu L. (1996)
YAC-transfer by microinjection.
In: Methods in Molecular Biology, volume 54, Yeast artificial chromosome protocols, Ed: Markie D., chapter 25: 293-306. Humana Press, Totowa (New Jersey).
MEDLINE

Montoliu L., Blendy J.A., Cole T.J. & Schütz G. (1995)
Analysis of perinatal gene expression: hormone response elements mediate activation of a LacZ reporter gene in liver of transgenic mice.
Proceedings of the National Academy of Sciences USA 92: 4244-4248. PDF
MEDLINE

PDF available as Open Access article at PubMed-Central

Montoliu L., Bock C.T., Schütz G. & Zentgraf H. (1995)
Visualization of large DNA molecules by electron microscopy with polyamines: Application to the analysis of yeast endogenous and artificial chromosomes.
Journal of Molecular Biology (1995) 246: 486-492. PDF
MEDLINE

Kaestner K.H., Montoliu L., Kern H., Thulke M. & Schutz G. (1994)
Universal beta-galactosidase cloning vectors for promoter analysis and gene targeting.
Gene 148(1):67-70.
MEDLINE

Montoliu L. (1994)
Fade to grey.
Current Biology 4: 1025.

Ganss R.*, Montoliu L.*, Monaghan A.P. & Schütz G. (1994)
A cell-specific enhancer far upstream of the mouse tyrosinase gene confers high level and copy number-related expression in transgenic mice.
The EMBO Journal 13: 3083-3093. PDF
MEDLINE

PDF available as Open Access article at PubMed-Central

Montoliu L., Schedl A., Kelsey G., Zentgraf H., Lichter P. & Schütz G. (1994)
Germ line transmission of yeast artificial chromosomes in transgenic mice.
Reproduction, Fertility & Development 6: 577-584.
MEDLINE

Jeffery G., Schütz G. & Montoliu L. (1994)
Correction of abnormal retinal pathways found with albinism by introduction of a functional tyrosinase gene in transgenic mice.
Developmental Biology 166: 460-464. PDF
MEDLINE

Schedl A., Larin Z., Montoliu L., Thies E., Kelsey G., Lehrach H. & Schütz G. (1993)
A method for the generation of YAC transgenic mice by pronuclear microinjection.
Nucleic Acids Research 21: 4783-4787. PDF
MEDLINE

PDF available as Open Access article at PubMed-Central

Schedl A.*, Montoliu L.*, Kelsey G. & Schütz G. (1993)
A 250 kb YAC covering the tyrosinase gene confers position independent and copy number dependent expression in transgenic mice.
Nature 362: 258-261. PDF
MEDLINE

Schedl A, Beermann F, Thies E, Montoliu L, Kelsey G & Schütz G. (1992)
Transgenic mice generated by pronuclear injection of a yeast artificial chromosome.
Nucleic Acids Research 20(12):3073-3077 PDF
MEDLINE

PDF available as Open Access article at PubMed-Central
 

Publications marked with PDF have corresponding PDF files available upon request by e-mail

Publications marked with PDF have corresponding PDF files available via Open Access archives

Search for publications by Lluís Montoliu in PUBMED

Medline links according to: