Genetic polymorphisms among C57BL/6 mouse inbred strains
by
Esther Zurita1,2, Mónica Chagoyen3, Marta Cantero1,2, Rosario Alonso4, Anna González-Neira4, Alejandro López-Jiménez6, José Antonio López-Moreno6, Carlisle P. Landel7, Javier Benítez2,4,5, Florencio Pazos3, Lluís Montoliu1,2,*
1 Dep. Molecular and Cellular Biology and 3 Systems Biology Program, Centro Nacional de Biotecnología (CNB-CSIC), Campus de Cantoblanco, Darwin 3, 28049 Madrid, Spain
2 Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Madrid, Spain
4 Human Genotyping-CEGEN Unit and 5 Human Genetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain
6 Department of Psychobiology, Faculty of Psychology, Complutense University of Madrid, Spain
7 Transgenic and Gene Targeting Facility, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
(*)Corresponding author:
Lluís Montoliu
Centro Nacional de Biotecnología (CNB-CSIC)
Campus de Cantoblanco, Darwin 3, 28049 Madrid (Spain)
tel.: +34915854844; fax.: +34915854506
E-mail: montoliu@cnb.csic.es
back to Lluis Montoliu's lab web page
Published in Transgenic Research
Zurita et al. (2010) epub: May 27, 2010
Acknowledgements
The authors are most grateful to Thomas J. Fielder, Ulrich Märki, Johannes Wilbertz and Elizabeth Williams for their useful comments and suggestions and, especially, their generous contribution of DNA and/or tissue samples from several mouse strains used in this study.
C57BL/6 mouse inbred substrains considered in this analysis:
C57BL/6JArc from ARC, Perth, Australia
C57BL/6J from The Jackson Laboratory
SNP panel used: Illumina® Mouse Medium Density (MD) Linkage Mapping panel (1449 SNPs)
Illumina® Datasheet (PDF file)
| Polymorphic SNPs useful to distinguish C57BL/6 substrains | Chromosome:position (Build 37.1) | C57BL/6JArc(ARC) | C57BL/6J (Jax) | C57BL/6J(Crl) | C57BL6/JRccHsd(Harlan) | C57BL/6JOlaHsd(Harlan) | C57BL/6JBomTac(Taconic) | B6(Cg)-Tyrc-2j/J(Jax) | C57BL/6NCrl(Crl) | C57BL/6NHsd(Harlan) | C57BL/6NTac(Taconic) | JM8.N4 ES cells |
| rs13477019 | 3 : 23723842 | T | T | T | A | A | A | A | A | A | A | A |
| rs31233932 | 14 : 124508019 | C | C | C | C | C | C | C | T | T | T | T |
| rs13480759 | 10 : 108815683 | C | C | C | C | C | C | C | T | T | T | T |
| rs29359333 | 10 : 57864252 | G | G | G | G | G | G | G | A | A | A | A |
| rs13483055 | 17 : 60459368 | T | T | T | C | C | C | T | C | C | C | C |
| rs13481734 | 13 : 27129019 | A | A | A | G | G | G | G | G | G | G | G |
| rs13480122 | 9 : 30964211 | T | T | T | T | T | T | T | C | C | C | C |
| rs13479522 | 7 : 136179208 | A | A | A | A | A | A | A | G | G | G | G |
| rs13478783 | 6 : 60541373 | A | A | A | A | A | A | A | G | G | G | G |
| rs13480619 | 10 : 57472268 | T | T | T | T | T | T | T | C | C | C | C |
| rs4165065 | 16 : 17412172 | T | T | T | T | T | T | T | C | C | C | C |
| rs13481014 | 11 : 47930884 | T | T | T | T | T | T | T | C | C | C | C |
Raw Data: Excel file with the 1449 SNPs and all C57BL/6 substrains analyzed
Data submitted to:
SNP collection of Projects held at Mouse Phenome Database (MPD)
CNB1 SNPs (available)
dbSNP database (NCBI) (in process)
back to Lluis Montoliu's lab web page
Last update: May 31, 2010