Domingo Barber

AUTOIMMUNE INFLAMMATORY DISEASES, CANCER IMMUNOTHERAPY AND NANOMEDICINE

Approximately 5-10% of the population in the developed world is affected by at least one of >80 autoimmune disorders; these chronic, debilitating diseases have an enormous social and economic impact. To analyse the mechanisms that operate in autoimmune diseases and identify new drug targets and therapeutic strategies, we study intracellular signaling pathways that induce autoimmunity or inflammation when hyperactivated, as well as the mechanisms that maintain peripheral tolerance in the immune system.