PLoS ONE García-Arriaza J, Nájera JL, Gómez CE, Tewabe N, Sorzano CO, Calandra T, Roger T, Esteban M . The vaccinia virus (VACV) C6 protein has sequence similarities with the poxvirus family Pox_A46, involved in regulation of host immune responses, but...
Biochimica et Biophysica Acta Pflüger-Grau K, Chavarría M, de Lorenzo V . Pseudomonas putida KT2440 is endowed with a variant of the phosphoenolpyruvate-carbohydrate phosphotransferase system (PTS(Ntr)), which is not related to sugar transport but...
PLoS Pathogens Dediego ML, Nieto-Torres JL, Jiménez-Guardeño JM, Regla-Nava JA, Alvarez E, Oliveros JC, Zhao J, Fett C, Perlman S, Enjuanes L . Severe acute respiratory syndrome virus (SARS-CoV) that lacks the envelope (E) gene (rSARS-CoV-ΔE) is...
Virology Goodman AG, Tanner BC, Chang ST, Esteban M, Katze MG. Previously we showed that the cellular protein P58(IPK) contributes to viral protein synthesis by decreasing the activity of the anti-viral protein, PKR. Here, we constructed a mathematical...
The Journal of Virology Mateos-Gómez PA, Zuñiga S, Palacio L, Enjuanes L, Sola I. Coronavirus subgenomic mRNA (sgmRNA) transcription requires a discontinuous RNA synthesis mechanism driven by the transcription-regulating sequences (TRSs), located at...
FEMS Microbiology Reviews Ayora S, Carrasco B, Cárdenas PP, César CE, Cañas C, Yadav T, Marchisone C, Alonso JC. In all living organisms, the response to double-strand breaks (DSBs) is critical for the maintenance of chromosome integrity. Homologous...
The Journal of Biological Chemistry García-Del Portillo F , Calvo E, D'Orazio V, Pucciarelli MG. Listeria monocytogenes is a Gram-positive intracellular bacterial pathogen that colonizes the cytosol of eukaryotic cells. Recent transcriptomic studies...
BMC Plant Biology Carbonell-Bejerano P, Urbez C, Granell A, Carbonell J, Perez-Amador MA. Ovule lifespan is an important factor in determining the ability to set fruits and produce seeds. Once ovule senescence is established, fruit set capacity in...
Molecular Microbiology Valls M, Silva-Rocha R, Cases I, Muñoz A, de Lorenzo V. The integration host factor (IHF) of Pseudomonas putida connects cell growth to transcriptional activity of distinct promoters. The IHF site of the σ 54 promoter Pu of the...
Transgenic Reserach Zurita E, Chagoyen M, Cantero M, Alonso R, González-Neira A, López-Jiménez A, López-Moreno JA, Landel CP, Benítez J, Pazos F, Montoliu L. Mice from the inbred C57BL/6 strain have been commonly used for the generation and analysis of...
Journal of Antimicrobial Chemotherapy Castañeda-García A, Do TT, Blázquez J. Rifampicin is an important first-line antibiotic for the treatment of mycobacterial infections. Although most rifampicin-resistant strains arise through mutations in the rpoB...
Current Opinion in Pharmacology Martínez JL , Baquero F, Andersson DI. Market launching of a new antibiotic requires knowing in advance its benefits and possible risks, and among them how rapidly resistance will emerge and spread among bacterial...
Nature Navarro C, Abelenda JA, Cruz-Oró E, Cuéllar CA, Tamaki S, Silva J, Shimamoto K, Prat S . Seasonal fluctuations in day length regulate important aspects of plant development such as the flowering transition or, in potato ( Solanum tuberosum ),...
The Plant Cell de Sena-Tomás C, Fernández-Álvarez A, Holloman WK, Pérez-Martín J . In the phytopathogenic fungus Ustilago maydis , the dikaryotic state dominates the period of growth occurring during the infectious phase. Dikaryons are cells in which...
Carcinogenesis Cerezo-Guisado MI, del Reino P, Remy G, Kuma Y, Arthur JS, Gallego-Ortega D, Cuenda A . The p38 mitogen-activated protein kinase (p38MAPK) signal transduction pathway is an important regulator of cell processes, whose deregulation leads...
Plant Signaling & Behavior Pérez-Martín J , de Sena-Tomás C. In a large group of fungi, mating results in a dikaryon, a cell in which the two nuclei -one from each parent cell- share a single cytoplasm for a period of time without undergoing nuclear...
The Journal of Bacteriology Palomino C, Marín E & Fernández LA . Fimbrial ushers are the largest β-barrel outer membrane proteins (OMPs) known to date, which function in the polymerization of fimbriae and their translocation to the bacterial surface....
PLoS One. 2010; 5(12):e15227 Blanco-Toribio A, Muyldermans S, Frankel G, Fernández LÁ . Intracellular proteins have a great potential as targets for therapeutic antibodies (Abs) but the plasma membrane prevents access to these antigens. Ab fragments...
PLoS ONE García-Arriaza J, Nájera JL, Gómez CE, Sorzano CO & Esteban M . The immune parameters of HIV/AIDS vaccine candidates that might be relevant in protection against HIV-1 infection are still undefined. The highly attenuated poxvirus strain MVA is...
The Plant Journal Godoy M, Franco-Zorrilla JM, Pérez-Pérez J, Oliveros JC, Lorenzo O & Solano R . Transcriptional regulation depends on the specificity of transcription factors (TFs) recognizing cis regulatory sequences in the promoters of target...
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