Oligomer Structure, Plasma Membrane Interactions and Activation of the EGF Receptor

Category
Seminarios - Seminario de Ciclo
Date
Friday, 07 March 2014 12:00
Venue
Salón de Actos del CNB - Calle Darwin, 3, 28049 Madrid
Madrid, España
COM_ICAGENDA_PONENTE
Dra. Marisa Martin-Fernandez . Central Laser Facility, Rutherford Appleton Laboratory, Oxford, United Kingdom
COM_ICAGENDA_CONTACTO
Dr. Jose L. Carrascosa
Telephone
91.585.45.09
COM_ICAGENDA_NOTES
The human epidermal growth factor receptor (EGFR/HER1) is the founding member of the HER family of receptor tyrosine kinases, which are initiators of signals for cell proliferation, differentiation, survival, and transformation. These receptors have an extracellular growth factor-binding domain, a single-pass transmembrane region, and an intracellular domain, that in EGFR, HER2 and HER4 has tyrosine kinase activity.