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Dr. Lluís Montoliu Research Scientist CSIC Departament of Molecular and Cellular Biology National Centre of Biotechnology (CNB-CSIC) Campus de Cantoblanco, C/ Darwin 3 28049 Madrid, Spain
Tel. +34 91 585-4844 (office) / +34 91 585-4530 (laboratory) Fax. +34 91 585-4506 / skype: lluis.montoliu e-mail:
montoliu@cnb.csic.es
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Células Madre y Terapia Regenerativa RANF, 2009
INFRAFRONTIER and EMMA at MICINN
Conference at the RANF
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Congenital defects and development disorders Research Group: Animal Models by Genetic Manipulation
Research Summary We are interested in understanding how mammalian expression domains work and how they are organised within genomes. We would like to know the required regulatory elements that identify a given expression domain and specify its expression pattern in space, time and level, to improve the dessign of gene transfer strategies, used for animal transgenesis and for gene therapy.
We use two experimental models: the mouse
tyrosinase and whey acidic protein genes, two independent
developmentally regulated and tissue-specific loci that have served us
to identify a number of
Further, our laboratory generates and analyses new animal models of human diseases by genetic modification of mice. We have used a number of tyrosinase transgenic mice to address the retinal deficits commonly associated with albinism, the normal mammalian retinal development and the genes involved in the process. Finally, through collaborations, we have a number of additional animal models (transgenics and knockouts) for CNS-related diseases or conditions (Alzheimer, pain, psychosis).
From January 1, 2009, CNB has become the Spanish node of the European Project EMMA.
Browse publications by Lluís Montoliu
Dr. Lluís Montoliu's Laboratory
(PDF documents)
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Molecular Biosciences (UAM) Course 2009-2010
Master in "Molecular and Cellular Biology" Master in "Molecular Biomedicine" Master in "Biotechnology"
Module BM5: Genomics, Proteomics & Genetic Modification
Previous post-graduate courses (1998-2010) Bioinformatic Resources (2005)
WEB and e-mail: histologia@cnb.csic.es Tel. +34 91585-5349 / 4903 NEW WEB - EMMA PROJECT
Mouse Embryo Cryopreservation Facility of CNB
WEB and e-mail: criocnb@cnb.csic.es Tel. +34 91585-5349 / 4312
Berlin (22-24 March 2010)
Protocols for the generation and analysis of transgenic mice
Laboratory protocols (restricted)
PhD thesis developed in Dr. Lluís Montoliu's laboratory
Database of transgenic mice, by Lluís Montoliu (2003)
Press here to request a free copy for academic-only use
"Generation of Transgenic Mice" by Lluís Montoliu (1997)
Press here to request a free copy for academic-only use
Information on albinism for scientists and for
Albinismo. Una condición genética, dos realidades: España y Senegal Book (in Spanish) edited by ALBA (www.albinismo.es) Pictures: Ana Yturralde Texts: Lucía Sapiña (España) / Rose Samb (Senegal) Prologue: Lluís Montoliu
Meetings, congresses, conferences and workshops organised
Legislación Europea, Nacional y Autonómica sobre protección de los animales utilizados para la experimentacion y otros fines cientificos y sobre el uso de organismos modificados genéticamente
CSIC Serrano 113 (1st floor) 28006 Madrid, Spain Tel. 915855458 Fax. 915645560
How to reach the CNB?
(Location of CNB at the Campus of the UAM) Pictures of CNB
Pictures of the city of Barcelona
Total Lunar eclipse, as seen from the North of Madrid at night on March 3-4, 2007
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key
regulatory elements, including boundaries and LCRs. We address our
experiments in vivo, using transgenic mice carrying large chromosomal-
type constructs that we engineer by homologous recombination to
investigate the functional role of specific sequences, and in vitro,
using cells and chromatin DNA-protein analyses.
Annual
research reports CNB
