Lab. Prof. Juan Ortín
Tel. +34 915854557 (office) / Tel. +34 915854561
(lab.)
Fax. +34 915854506
Análisis estructural y funcional de la replicación
y expresión génica del RNA del virus de la gripe.
Structural and functional
analyses of influenza virus RNA replication and gene expression.
Juan Ortín
Montón
Patricia
Villace Lozano
Yolanda Fernández
Moron
Susana de
Lucas Arias
Eva Maria
Torreira Ontiveros
Urtzi Garaigorta
de Dios
Nuria Jorba
Grifols
Rocío
Coloma Ciudad
Publicaciones recientes / Recent Publications:
Villace P, Marion RM, Ortin J. (2004)
The
composition of Staufen-containing RNA granules from human cells indicates
their role in the regulated transport and translation of messenger RNAs.
Nucleic Acids Research 32(8):2411-2420.
Falcon AM, Marion RM, Zurcher T, Gomez P, Portela
A, Nieto A, Ortin J. (2004)
Defective
RNA replication and late gene expression in temperature-sensitive influenza
viruses expressing deleted forms of the NS1 protein.
Journal of Virology 78(8):3880-3888.
Area E, Martin-Benito J, Gastaminza P, Torreira
E, Valpuesta JM, Carrascosa JL, Ortin J. (2004)
3D
structure of the influenza virus polymerase complex: localization of subunit
domains.
Proceedings of the National Academy of Sciences
U S A. 101(1):308-313.
Burgui I, Aragon T, Ortin J, Nieto A.(2003)
PABP1
and eIF4GI associate with influenza virus NS1 protein in viral mRNA translation
initiation complexes.
Journal of General Virology 84:3263-3274.
Huarte M, Falcon A, Nakaya Y, Ortin J, Garcia-Sastre
A, Nieto A.(2003)
Threonine
157 of influenza virus PA polymerase subunit modulates RNA replication
in infectious viruses.
Journal of Virology 77(10):6007-6013.
Ortin J. (2003)
Unraveling
the replication machine from negative-stranded RNA viruses.
Structure (Camb) 11(10):1194-1196.
Gastaminza P, Perales B, Falcon AM, Ortin J. (2003)
Mutations
in the N-terminal region of influenza virus PB2 protein affect virus RNA
replication but not transcription.
Journal of Virology 77(9):5098-5108.