Departamento de Biología Molecular y Celular
Department of Molecular and Cellular Biology
CNB-CSIC

Lab. Prof. Juan Ortín

Tel. +34 915854557 (office) / Tel. +34 915854561 (lab.)
Fax. +34 915854506

 Laboratory WEB page



Objetivos / Aims

Análisis estructural y funcional de la replicación y expresión génica del RNA del virus de la gripe.
Structural and functional analyses of influenza virus RNA replication and gene expression.

Memoria Científica 2003-2004

Research Summary 2003-2004


Personal / Staff

Juan Ortín Montón
Patricia Villace Lozano
Yolanda Fernández Moron
Susana de Lucas Arias
Eva Maria Torreira Ontiveros
Urtzi Garaigorta de Dios
Nuria Jorba Grifols
Rocío Coloma Ciudad


Publicaciones recientes / Recent Publications:

Villace P, Marion RM, Ortin J. (2004)
The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs.
Nucleic Acids Research 32(8):2411-2420.

Falcon AM, Marion RM, Zurcher T, Gomez P, Portela A, Nieto A, Ortin J. (2004)
Defective RNA replication and late gene expression in temperature-sensitive influenza viruses expressing deleted forms of the NS1 protein.
Journal of Virology 78(8):3880-3888.

Area E, Martin-Benito J, Gastaminza P, Torreira E, Valpuesta JM, Carrascosa JL, Ortin J. (2004)
3D structure of the influenza virus polymerase complex: localization of subunit domains.
Proceedings of the National Academy of Sciences U S A. 101(1):308-313.

Burgui I, Aragon T, Ortin J, Nieto A.(2003)
PABP1 and eIF4GI associate with influenza virus NS1 protein in viral mRNA translation initiation complexes.
Journal of General Virology 84:3263-3274.

Huarte M, Falcon A, Nakaya Y, Ortin J, Garcia-Sastre A, Nieto A.(2003)
Threonine 157 of influenza virus PA polymerase subunit modulates RNA replication in infectious viruses.
Journal of Virology 77(10):6007-6013.

Ortin J. (2003)
Unraveling the replication machine from negative-stranded RNA viruses.
Structure (Camb) 11(10):1194-1196.

Gastaminza P, Perales B, Falcon AM, Ortin J. (2003)
Mutations in the N-terminal region of influenza virus PB2 protein affect virus RNA replication but not transcription.
Journal of Virology 77(9):5098-5108.
 



Last update: 14 February 2006
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