Lab. Dr. Antonio Alcamí
Tel. +34 915854837 (office) / Tel. +34 915854678
(lab.)
Fax. +34 915854506
La identificacion de mecanismos de evasión
del sistema inmune codificados por poxvirus y herpesvirus (proteínas
secretadas de la célula infectada que neutralizan la actividad de
citoquinas y quimioquinas).
The identification of evasion
mechanisms of the immuse system encoded by poxviruses and herpesviruses
(secreted proteins by the infected cell that neutralise the activity of
cytokines and quimiokines).
Antonio Alcamí
Marcos Palomo
Otero
Ali Gabriel
Alejo Herberg
María
Begoña Ruiz Argüello
Abel Viejo
Borbolla
María
Rocío Martín Hernández
Edel McNeela
Alberto López
Bueno
Publicaciones recientes / Recent Publications:
Smith P, Fallon RE, Mangan NE, Walsh CM, Saraiva
M, Sayers JR, McKenzie AN, Alcami A, Fallon PG. (2005)
Schistosoma
mansoni secretes a chemokine binding protein with antiinflammatory activity.
J Exp Med. 202(10):1319-25.
Costes B, Ruiz-Arguello MB, Bryant NA, Alcami A,
Vanderplasschen A. (2005)
Both
soluble and membrane-anchored forms of Felid herpesvirus 1 glycoprotein
G function as a broad-spectrum chemokine-binding protein.
J Gen Virol. 86(Pt 12):3209-14.
Webb LM, Alcami A. (2005)
Virally
encoded chemokine binding proteins.
Mini Rev Med Chem. 5(9):833-48.
Stober CB, Lange UG, Roberts MT, Alcami A, Blackwell
JM (2005)
IL-10
from regulatory T cells determines vaccine efficacy in murine Leishmania
major infection.
Journal of Immunology 175(4):2517-24.
Jamieson T, Cook DN, Nibbs RJ, Rot A, Nixon C, McLean
P, Alcami A, Lira SA, Wiekowski M, Graham GJ (2005)
The
chemokine receptor D6 limits the inflammatory response in vivo.
Nature Immunology 6(4):403-11.
Pyo R, Jensen KK, Wiekowski MT, Manfra D, Alcami
A, Taubman MB, Lira SA. (2004)
Inhibition
of intimal hyperplasia in transgenic mice conditionally expressing the
chemokine-binding protein M3.
American Journal of Pathology 164(6):2289-2297.
Webb LM, Smith VP, Alcami A. (2004)
The
gammaherpesvirus chemokine binding protein can inhibit the interaction
of chemokines with glycosaminoglycans.
FASEB Journal 18(3):571-573.
Alcami A. (2004)
Interaction
of viral chemokine inhibitors with chemokines.
Methods in Molecular Biology 239:167-180.
Ribas G, Rivera J, Saraiva M, Campbell RD, Alcami
A. (2003)
Genetic
variability of immunomodulatory genes in ectromelia virus isolates detected
by denaturing high-performance liquid chromatography.
Journal of Virology 77(18):10139-10146.
Webb LM, Clark-Lewis I, Alcami A. (2003)
The
gammaherpesvirus chemokine binding protein binds to the N terminus of CXCL8.
Journal of Virology 77(15):8588-8592.
Alcami A. (2003)
Structural
basis of the herpesvirus M3-chemokine interaction.
Trends in Microbiology 11(5):191-192.
Bryant NA, Davis-Poynter N, Vanderplasschen A, Alcami
A. (2003)
Glycoprotein
G isoforms from some alphaherpesviruses function as broad-spectrum chemokine
binding proteins.
The EMBO Journal 22(4):833-846.
Alcami A. (2003)
Viral
mimicry of cytokines, chemokines and their receptors.
Nature Reviews in Immunology 3(1):36-50.
Jensen KK, Chen SC, Hipkin RW, Wiekowski MT, Schwarz
MA, Chou CC, Simas JP, Alcami A, Lira SA. (2003)
Disruption
of CCL21-induced chemotaxis in vitro and in vivo by M3, a chemokine-binding
protein encoded by murine gammaherpesvirus 68.
Journal of Virology 77(1):624-630.