Departamento de Biología Molecular y Celular
Department of Molecular and Cellular Biology
CNB-CSIC

Lab. Dr. Antonio Alcamí

Tel. +34 915854837 (office) / Tel. +34 915854678 (lab.)
Fax. +34 915854506

 Laboratory WEB page



Objetivos / Aims

La identificacion de mecanismos de evasión del sistema inmune codificados por poxvirus y herpesvirus (proteínas secretadas de la célula infectada que neutralizan la actividad de citoquinas y quimioquinas).
The identification of evasion mechanisms of the immuse system encoded by poxviruses and herpesviruses (secreted proteins by the infected cell that neutralise the activity of cytokines and quimiokines).

Memoria Científica 2003-2004

Research Summary 2003-2004


Personal / Staff

Antonio Alcamí
Marcos Palomo Otero
Ali Gabriel Alejo Herberg
María Begoña Ruiz Argüello
Abel Viejo Borbolla
María Rocío Martín Hernández
Edel McNeela
Alberto López Bueno


Publicaciones recientes / Recent Publications:

Smith P, Fallon RE, Mangan NE, Walsh CM, Saraiva M, Sayers JR, McKenzie AN, Alcami A, Fallon PG. (2005)
Schistosoma mansoni secretes a chemokine binding protein with antiinflammatory activity.
J Exp Med. 202(10):1319-25.

Costes B, Ruiz-Arguello MB, Bryant NA, Alcami A, Vanderplasschen A. (2005)
Both soluble and membrane-anchored forms of Felid herpesvirus 1 glycoprotein G function as a broad-spectrum chemokine-binding protein.
J Gen Virol. 86(Pt 12):3209-14.

Webb LM, Alcami A. (2005)
Virally encoded chemokine binding proteins.
Mini Rev Med Chem. 5(9):833-48.

Stober CB, Lange UG, Roberts MT, Alcami A, Blackwell JM (2005)
IL-10 from regulatory T cells determines vaccine efficacy in murine Leishmania major infection.
Journal of Immunology 175(4):2517-24.

Jamieson T, Cook DN, Nibbs RJ, Rot A, Nixon C, McLean P, Alcami A, Lira SA, Wiekowski M, Graham GJ (2005)
The chemokine receptor D6 limits the inflammatory response in vivo.
Nature Immunology 6(4):403-11.

Pyo R, Jensen KK, Wiekowski MT, Manfra D, Alcami A, Taubman MB, Lira SA. (2004)
Inhibition of intimal hyperplasia in transgenic mice conditionally expressing the chemokine-binding protein M3.
American Journal of Pathology 164(6):2289-2297.

Webb LM, Smith VP, Alcami A. (2004)
The gammaherpesvirus chemokine binding protein can inhibit the interaction of chemokines with glycosaminoglycans.
FASEB Journal 18(3):571-573.

Alcami A. (2004)
Interaction of viral chemokine inhibitors with chemokines.
Methods in Molecular Biology 239:167-180.

Ribas G, Rivera J, Saraiva M, Campbell RD, Alcami A. (2003)
Genetic variability of immunomodulatory genes in ectromelia virus isolates detected by denaturing high-performance liquid chromatography.
Journal of Virology 77(18):10139-10146.

Webb LM, Clark-Lewis I, Alcami A. (2003)
The gammaherpesvirus chemokine binding protein binds to the N terminus of CXCL8.
Journal of Virology 77(15):8588-8592.

Alcami A. (2003)
Structural basis of the herpesvirus M3-chemokine interaction.
Trends in Microbiology 11(5):191-192.

Bryant NA, Davis-Poynter N, Vanderplasschen A, Alcami A. (2003)
Glycoprotein G isoforms from some alphaherpesviruses function as broad-spectrum chemokine binding proteins.
The EMBO Journal 22(4):833-846.

Alcami A. (2003)
Viral mimicry of cytokines, chemokines and their receptors.
Nature Reviews in Immunology 3(1):36-50.

Jensen KK, Chen SC, Hipkin RW, Wiekowski MT, Schwarz MA, Chou CC, Simas JP, Alcami A, Lira SA. (2003)
Disruption of CCL21-induced chemotaxis in vitro and in vivo by M3, a chemokine-binding protein encoded by murine gammaherpesvirus 68.
Journal of Virology 77(1):624-630.



Last update: 14 February 2006
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