List of scientific Publications (click on titles for more information)

  1. Evaluation of homo- and hetero-functionally activated glass surfaces for Optimized Antibody Array. Analytical Biochemistry. 2014. DOI: http://dx.doi.org/10.1016/j.ab.2014.01.002.
  2. Protein-protein interactions: gene acronym redundancies and current limitations precluding fully automated data integration. Casado-Vela, J. et al. Proteomes. 1(1), 3-24. 2013.
  3. Lights and shadows of proteomic technologies for the study of protein species including isoforms, splicing variants and protein post-translational modifications. Casado-Vela, J. et al. Proteomics. 2011 Feb;11(4):590-603.
  4. Approaches for the study of cancer: towards the integration of genomics, proteomics and metabolomics. Casado-Vela, J. Clin Transl Oncol. 2011 Sep;13(9):617-28.
  5. Data Analysis Strategies for Protein Microarrays. Microarrays. 2012, 1(2), 64-83.
  6. Protein arrays: recent achievements and their application to study the human proteome. Current Proteomics. Casado-Vela, J. et al. 10, 83-97, 2013.
  7. Biological methods for metabolic research. In: Methodologies for Metabolomics. Experimental strategies and techniques. 54-76. 2013. Editors: Norbert W. Lutz, Jonathan V. Sweedler & Ron A. Wevers. Cambridge University Press. Chapter DOI: http://dx.doi.org/10.1017/CBO9780511996634.004
  8. A neuroprotective phase precedes striatal degeneration upon nucleolar stress. Cell Death and Differentiation. 2013.
  9. Neuronal Ca(2+) dyshomeostasis in Huntington disease. Prion. 7(1):76-84. 2013.
  10. The strength of the corticospinal coherence depends on the predictability of modulated isometric forces. Neurophysiol. 109(6):1579-88. 2013.
  11. Protein-protein interactions: gene acronym redundancies and current limitations precluding fully automated data integration. Casado-Vela, Juan; Matthiesen, Rune; Sellés, S.; Naranjo, José Ramón. Proteomes. 1(1), 3-24. 2013. Over 600 downloads (see statistics here).
  12. Lights and shadows of proteomic technologies for the study of protein species including isoforms, splicing variants and protein post-translational modifications. Casado-Vela J et al. Proteomics. 2011 Feb;11(4):590-603.
  13. Approaches for the study of cancer: towards the integration of genomics, proteomics and metabolomics. Casado-Vela J. Clin Transl Oncol. 2011 Sep;13(9):617-28.
  14. Data Analysis Strategies for Protein Microarrays. Microarrays 2012, 1(2), 64-83. Over 800 downloads.
  15. DREAM Mediated Regulation of GCM1 in the Human Placental Trophoblast. PLoS One. 2013;8(1):e51837.
  16. Protein chimerism: Novel source of protein diversity in humans adds complexity to bottom-up proteomics. Casado-Vela J. Proteomics. 2013 Jan;13(1):5-11.
  17. The Neuronal Functions of EF-Hand Ca2+-Binding Proteins. Front Mol Neurosci. 2012;5:92.
  18. Ca2+-dependent transcriptional control of Ca2+ homeostasis. Naranjo JR, Mellström B. J Biol Chem. 2012 Sep 14;287(38):31674-80.
  19. Reduced Mid1 Expression and Delayed Neuromotor Development in daDREAM Transgenic Mice. Naranjo JR. Front Mol Neurosci. 2012;5:58.
  20. Ca2+-activated nucleotidase 1, a novel target gene for the transcriptional repressor DREAM (downstream regulatory element antagonist modulator), is involved in protein folding and degradation. J Biol Chem. 2012 May 25;287(22):18478-91.
  21. DREAM regulates BDNF-dependent spinal sensitization. Mol Pain. 2010 Dec 18;6:95.
  22. Sumoylation regulates nuclear localization of repressor DREAM. Palczewska M, Casafont I, Ghimire K, Rojas AM, Valencia A, Lafarga M, Mellström B, Naranjo JR. Biochim Biophys Acta. 2011 May;1813(5):1050-8.
  23. Increased B cell proliferation and reduced Ig production in DREAM transgenic mice. J Immunol. 2010 Dec 15;185(12):7527-36.
  24. Redox signaling regulates transcriptional activity of the Ca2+-dependent repressor DREAM. Antioxid Redox Signal. 2011 Apr 1;14(7):1237-43.
  25. DREAM (downstream regulatory element antagonist modulator) contributes to synaptic depression and contextual fear memory. Mol Brain. 2010 Jan 21;3:3.
  26. Diffusion nuclear magnetic resonance spectroscopy detects substoichiometric concentrations of small molecules in protein samples. Ribeiro JP, Palczewska M, André S, Cañada FJ, Gabius HJ, Jiménez-Barbero J, Mellström B, Naranjo JR, Scheffers DJ, Groves P. Anal Biochem. 2010 Jan 1;396(1):117-23.
  27. The DREAM protein is associated with thyroid enlargement and nodular development. Mol Endocrinol. 2009 Jun;23(6):862-70.
  28. Specific effects of KChIP3/calsenilin/DREAM, but not KChIPs 1, 2 and 4, on calcium signalling and regulated secretion in PC12 cells. Venn N, Haynes LP, Burgoyne RD. Biochem J. 2008 Jul 1;413(1):71-80.
  29. Ca2+-operated transcriptional networks: molecular mechanisms and in vivo models. Mellström B, Savignac M, Gomez-Villafuertes R, Naranjo JR. Physiol Rev. 2008 Apr;88(2):421-49.
  30. Searching for a role of NCX/NCKX exchangers in neurodegeneration. Gomez-Villafuertes R, Mellström B, Naranjo JR. Mol Neurobiol. 2007 Apr;35(2):195-202.
  31. Calcium-dependent transcription of cytokine genes in T lymphocytes. Savignac M, Mellström B, Naranjo JR. Pflugers Arch. 2007 Jul;454(4):523-33.
  32. Split personality of transcription factors inside and outside the nuclear border. Naranjo JR, Mellström B. Sci STKE. 2007 Jan 30;2007(371):pe5.
  33. G protein-coupled receptor kinase 2-mediated phosphorylation of downstream regulatory element antagonist modulator regulates membrane trafficking of Kv4.2 potassium channel. J Biol Chem. 2007 Jan 12;282(2):1205-15.
  34. Gas1 is related to the glial cell-derived neurotrophic factor family receptors alpha and regulates Ret signaling. Cabrera JR, Sanchez-Pulido L, Rojas AM, Valencia A, Mañes S, Naranjo JR, Mellström B. J Biol Chem. 2006 May 19;281(20):14330-9.
  35. Downstream regulatory element antagonist modulator regulates Ca2+ homeostasis and viability in cerebellar neurons. Gomez-Villafuertes R, Torres B, Barrio J, Savignac M, Gabellini N, Rizzato F, Pintado B, Gutierrez-Adan A, Mellström B, Carafoli E, Naranjo JR. J Neurosci. 2005 Nov 23;25(47):10822-30.
  36. Transcriptional repressor DREAM regulates T-lymphocyte proliferation and cytokine gene expression. Mellström B, Naranjo JR. EMBO J. 2005 Oct 19;24(20):3555-64.
  37. The repressor DREAM acts as a transcriptional activator on Vitamin D and retinoic acid response elements. Scsucova S, Palacios D, Savignac M, Mellström B, Naranjo JR, Aranda A. Nucleic Acids Res. 2005 Apr 22;33(7):2269-79.
  38. The BDNF gene: exemplifying complexity in Ca2+ -dependent gene expression. Mellstrom B, Torres B, Link WA, Naranjo JR. Crit Rev Neurobiol. 2004;16(1-2):43-9.
  39. Day-night changes in downstream regulatory element antagonist modulator/potassium channel interacting protein activity contribute to circadian gene expression in pineal gland. Link WA, Ledo F, Torres B, Palczewska M, Madsen TM, Savignac M, Albar JP, Mellström B, Naranjo JR. J Neurosci. 2004 Jun 9;24(23):5346-55.
  40. Transcriptional repressor DREAM interacts with thyroid transcription factor-1 and regulates thyroglobulin gene expression. Rivas M, Mellström B, Naranjo JR, Santisteban P. J Biol Chem. 2004 Aug 6;279(32):33114-22.
  41. Glial-specific retrovirally mediated gas1 gene expression induces glioma cell apoptosis and inhibits tumor growth in vivo. Zamorano A, Mellström B, Vergara P, Naranjo JR, Segovia J. Neurobiol Dis. 2004 Apr;15(3):483-91.
  42. Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol. Klattenhoff C, Montecino M, Soto X, Guzmán L, Romo X, García MA, Mellstrom B, Naranjo JR, Hinrichs MV, Olate J. J Cell Physiol. 2003 May;195(2):151-7.
  43. Ca2+-dependent block of CREB-CBP transcription by repressor DREAM. Ledo F, Kremer L, Mellström B, Naranjo JR. EMBO J. 2002 Sep 2;21(17):4583-92.
  44. Mechanisms of Ca(2+)-dependent transcription. Mellström B, Naranjo JR. Curr Opin Neurobiol. 2001 Jun;11(3):312-9.
  45. Interleukin 3-dependent activation of DREAM is involved in transcriptional silencing of the apoptotic Hrk gene in hematopoietic progenitor cells. Sanz C, Mellstrom B, Link WA, Naranjo JR, Fernandez-Luna JL. EMBO J. 2001 May 1;20(9):2286-92.
  46. Ca2+-dependent transcriptional repression and derepression: DREAM, a direct effector. Mellström B, Naranjo JR. Semin Cell Dev Biol. 2001 Feb;12(1):59-63.
  47. The DREAM-DRE interaction: key nucleotides and dominant negative mutants. Ledo F, Link WA, Carrión AM, Echeverria V, Mellström B, Naranjo JR. Biochim Biophys Acta. 2000 Dec 20;1498(2-3):162-8.
  48. DREAM-alphaCREM interaction via leucine-charged domains derepresses downstream regulatory element-dependent transcription. Ledo F, Carrión AM, Link WA, Mellström B, Naranjo JR. Mol Cell Biol. 2000 Dec;20(24):9120-6.
  49. Induction of glycerol phosphate dehydrogenase gene expression during seizure and analgesia. Link WA, Kauselmann G, Mellström B, Kuhl D, Naranjo JR. J Neurochem. 2000 Oct;75(4):1419-28.
  50. DREAM is a Ca2+-regulated transcriptional repressor. Carrión AM, Link WA, Ledo F, Mellström B, Naranjo JR. Nature. 1999 Mar 4;398(6722):80-4.
  51. Protein kinase A-dependent derepression of the human prodynorphin gene via differential binding to an intragenic silencer element. Carrión AM, Mellström B, Naranjo JR.
  52. Metamizol potentiates morphine effects on visceral pain and evoked c-Fos immunoreactivity in spinal cord. Taylor J, Mellström B, Fernaud I, Naranjo JR. Eur J Pharmacol. 1998 Jun 12;351(1):39-47.
  53. Peripheral noxious stimulation induces CREM expression in dorsal horn: involvement of glutamate. Naranjo JR, Mellström B, Carrión AM, Lucas JJ, Foulkes NS, Sassone-Corsi P. Eur J Neurosci. 1997 Dec;9(12):2778-83.
  54. Stimulus-specific hierarchy of enhancer elements within the rat prodynorphin promoter. Carrión AM, Mellström B, Luckman SM, Naranjo JR. J Neurochem. 1998 Mar;70(3):914-21.
  55. Identification and functional characterization of a K+ channel alpha-subunit with regulatory properties specific to brain. Castellano A, Chiara MD, Mellström B, Molina A, Monje F, Naranjo JR, López-Barneo J. J Neurosci. 1997 Jun 15;17(12):4652-61.
  56. Experimental brain glioma: growth arrest and destruction by a blood-group-related tetrasaccharide. Nieto-Sampedro M, Bailón C, Fernández-Mayoralas A, Martín-Lomas M, Mellström B, Naranjo JR. J Neuropathol Exp Neurol. 1996 Feb;55(2):169-77.
  57. Functional N-methyl-D-aspartate receptors in clonal rat phaeochromocytoma cells. Casado M, López-Guajardo A, Mellström B, Naranjo JR, Lerma J. J Physiol. 1996 Jan 15;490:391-404.
  58. Expression of the bovine striatal D2 receptor, but not the D1 receptor, in bovine adrenal medulla. Maroto R, López MG, del Valle M, Naranjo JR, Mellström B, García AG. Mol Pharmacol. 1995 Jan;47(1):40-50.
  59. Differential effect of thyroid hormone on NGFI-A gene expression in developing rat brain. Mellström B, Pipaón C, Naranjo JR, Perez-Castillo A, Santos A. Endocrinology. 1994 Aug;135(2):583-8.
  60. Functional kainate-selective glutamate receptors in cultured hippocampal neurons. Lerma J, Paternain AV, Naranjo JR, Mellström B. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11688-92.
  61. VIP gene expression in rat thymus and spleen. Gomariz RP, Delgado M, Naranjo JR, Mellström B, Tormo A, Mata F, Leceta J. Brain Behav Immun. 1993 Dec;7(4):271-8.
  62. Nuclear Fos domains in transcriptionally activated supraoptic nucleus neurons. Lafarga M, Martinez-Guijarro FJ, Berciano MT, Blasco-Ibañez JM, Andres MA, Mellström B, Lopez-Garcia C, Naranjo JR. Neuroscience. 1993 Nov;57(2):353-64.
  63. Molecular mechanisms of pain: serotonin1A receptor agonists trigger transactivation by c-fos of the prodynorphin gene in spinal cord neurons. Lucas JJ, Mellström B, Colado MI, Naranjo JR. Neuron. 1993 Apr;10(4):599-611.
  64. Transcriptional response to cAMP in brain: specific distribution and induction of CREM antagonists. Mellström B, Naranjo JR, Foulkes NS, Lafarga M, Sassone-Corsi P. Neuron. 1993 Apr;10(4):655-65.
  65. Fos-like expression and nuclear size in osmotically stimulated supraoptic nucleus neurons. Lafarga M, Berciano MT, Martinez-Guijarro FJ, Andres MA, Mellström B, Lopez-Garcia C, Naranjo JR. Neuroscience. 1992 Oct;50(4):867-75.
  66. Narine occlusion decreases basal levels of Fos protein in the cerebral cortex of the lizard Podarcis hispanica. Blasco-Ibañez JM, Martinez-Guijarro FJ, Lopez-Garcia C, Mellström B, Naranjo JR. Neuroscience. 1992 Oct;50(3):647-54.
  67. Differential expression of the jun family members in rat brain. Mellström B, Achaval M, Montero D, Naranjo JR, Sassone-Corsi P. Oncogene. 1991 Nov;6(11):1959-64.
  68. Independent expression of the alpha and beta c-erbA genes in developing rat brain. Mellström B, Naranjo JR, Santos A, Gonzalez AM, Bernal J. Mol Endocrinol. 1991 Sep;5(9):1339-50.
  69. Molecular pathways of pain: Fos/Jun-mediated activation of a noncanonical AP-1 site in the prodynorphin gene. Naranjo JR, Mellström B, Achaval M, Sassone-Corsi P. Neuron. 1991 Apr;6(4):607-17.
  70. Transient expression of c-fos during the development of the rat cerebral cortex. González-Martín C, de Diego I, Fairén A, Mellström B, Naranjo JR. Brain Res Dev Brain Res. 1991 Mar 18;59(1):109-12.
  71. Co-induction of jun B and c-fos in a subset of neurons in the spinal cord. Naranjo JR, Mellström B, Achaval M, Lucas JJ, Del Rio J, Sassone-Corsi P. Oncogene. 1991 Feb;6(2):223-7.
  72. Unusual c-fos induction upon chromaffin PC12 differentiation by sodium butyrate: loss of fos autoregulatory function. Naranjo JR, Mellström B, Auwerx J, Mollinedo F, Sassone-Corsi P. Nucleic Acids Res. 1990 Jun 25;18(12):3605-10.
  73. Negative feedback regulation of the content of proenkephalin mRNA in chromaffin cell cultures. Naranjo JR. Neuropharmacology. 1988 Apr;27(4):337-43.
  74. Evaluation of homo- and hetero-functionally activated glass surfaces for optimized antibody arrays. González-González M, Bartolome R, Jara-Acevedo R, Casado-Vela J, Dasilva N, Matarraz S, García J, Alcazar JA, Sayagues JM, Orfao A, Fuentes M. Anal Biochem. 2014 Jan 15;450C:37-45. doi: 10.1016/j.ab.2014.01.002.
  75. Differential proteome analysis by isobaric tags for relative and absolute quantitation (iTRAQ). Martínez-Esteso MJ, Casado-Vela J, Sellés-Marchart S, Pedreño MA, Bru-Martínez R. Methods Mol Biol. 2014;1072:155-69. doi: 10.1007/978-1-62703-631-3_12.
  76. High-throughput proteomic characterization of plasma rich in growth factors (PRGF-Endoret)-derived fibrin clot interactome. Anitua E, Prado R, Azkargorta M, Rodriguez-Suárez E, Iloro I, Casado-Vela J, Elortza F, Orive G. J Tissue Eng Regen Med. 2013 Mar 18. doi: 10.1002/term.1721.
  77. Protein chimerism: novel source of protein diversity in humans adds complexity to bottom-up proteomics. Casado-Vela J, Lacal JC, Elortza F. Proteomics. 2013 Jan;13(1):5-11. doi: 10.1002/pmic.201200371.
  78. Uromodulin and α(1)-antitrypsin urinary peptide analysis to differentiate glomerular kidney diseases.Navarro-Muñoz M, Ibernon M, Bonet J, Pérez V, Pastor MC, Bayés B, Casado-Vela J, Navarro M, Ara J, Espinal A, Fluvià L, Serra A, López D, Romero R. Kidney Blood Press Res. 2012;35(5):314-25. doi: 10.1159/000335383.
  79. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). Lopitz-Otsoa F, Rodriguez-Suarez E, Aillet F, Casado-Vela J, Lang V, Matthiesen R, Elortza F, Rodriguez MS. J Proteomics. 2012 Jun 6;75(10):2998-3014. doi: 10.1016/j.jprot.2011.12.001.
  80. Approaches for the study of cancer: towards the integration of genomics, proteomics and metabolomics. Casado-Vela J, Cebrián A, Gómez del Pulgar MT, Lacal JC. Clin Transl Oncol. 2011 Sep;13(9):617-28. doi: 10.1007/s12094-011-0707-9.
  81. Human urine proteomics: building a list of human urine cancer biomarkers. Casado-Vela J, Gómez del Pulgar T, Cebrián A, Alvarez-Ayerza N, Lacal JC. Expert Rev Proteomics. 2011 Jun;8(3):347-60. doi: 10.1586/epr.11.26.
  82. Lights and shadows of proteomic technologies for the study of protein species including isoforms, splicing variants and protein post-translational modifications. Casado-Vela J, Cebrián A, Gómez del Pulgar MT, Sánchez-López E, Vilaseca M, Menchén L, Diema C, Sellés-Marchart S, Martínez-Esteso MJ, Yubero N, Bru-Martínez R, Lacal JC. Proteomics. 2011 Feb;11(4):590-603. doi: 10.1002/pmic.201000287. Epub 2011 Jan 13.
  83. Cohesin organizes chromatin loops at DNA replication factories. Guillou E, Ibarra A, Coulon V, Casado-Vela J, Rico D, Casal I, Schwob E, Losada A, Méndez J. Genes Dev. 2010 Dec 15;24(24):2812-22. doi: 10.1101/gad.608210.
  84. A p120-catenin-CK1epsilon complex regulates Wnt signaling. Casagolda D, Del Valle-Pérez B, Valls G, Lugilde E, Vinyoles M, Casado-Vela J, Solanas G, Batlle E, Reynolds AB, Casal JI, de Herreros AG, Duñach M. J Cell Sci. 2010 Aug 1;123(Pt 15):2621-31. doi: 10.1242/jcs.067512.
  85. Novel snail1 target proteins in human colon cancer identified by proteomic analysis. Larriba MJ, Casado-Vela J, Pendás-Franco N, Peña R, García de Herreros A, Berciano MT, Lafarga M, Casal JI, Muñoz A. PLoS One. 2010 Apr 20;5(4):e10221. doi: 10.1371/journal.pone.0010221.
  86. Expression of serine proteases in egg-parasitic nematophagous fungi during barley root colonization. Lopez-Llorca LV, Gómez-Vidal S, Monfort E, Larriba E, Casado-Vela J, Elortza F, Jansson HB, Salinas J, Martín-Nieto J. Fungal Genet Biol. 2010 Apr;47(4):342-51. doi: 10.1016/j.fgb.2010.01.004.
  87. iTRAQ-based quantitative analysis of protein mixtures with large fold change and dynamic range. Casado-Vela J, Martínez-Esteso MJ, Rodriguez E, Borrás E, Elortza F, Bru-Martínez R. Proteomics. 2010 Jan;10(2):343-7. doi: 10.1002/pmic.200900509.
  88. Comprehensive proteomic analysis of human endometrial fluid aspirate. Casado-Vela J, Rodriguez-Suarez E, Iloro I, Ametzazurra A, Alkorta N, García-Velasco JA, Matorras R, Prieto B, González S, Nagore D, Simón L, Elortza F. J Proteome Res. 2009 Oct;8(10):4622-32. doi: 10.1021/pr9004426.
  89. Differential phosphorylation patterns between the Cyclin-A2/CDK2 complex and their monomers. Casado-Vela J, Martínez-Torrecuadrada JL, Casal JI. Protein Expr Purif. 2009 Jul;66(1):15-21. doi: 10.1016/j.pep.2009.02.007.
  90. A combination of neutral loss and targeted product ion scanning with two enzymatic digestions facilitates the comprehensive mapping of phosphorylation sites. Casado-Vela J, Ruiz EJ, Nebreda AR, Casal JI. Proteomics. 2007 Aug;7(15):2522-9.