XXXI Workshop ADVANCES IN MOLECULAR BIOLOGY BY YOUNG RESEARCHERS ABROAD
Presentación de los avances anuales de los proyectos de investigación Fundación Jesús Serra en el CNB-CSIC
- Fundación Jesús Serra de GCO (Grupo Catalana Occidente) financia varios proyectos científicos en el Centro Nacional de Biotecnología (CNB-CSIC)
- Un año después del comienzo de los proyectos, los grupos seleccionados cuentan los avances de su investigación en una jornada celebrada en el CNB-CSIC.
La primera convocatoria de ayudas a la investigación Fundación Jesús Serra para jóvenes investigadores en el CNB-CSIC cumple un año, y los grupos seleccionados se han reunido en Madrid junto a representantes de Fundación Jesús Serra para presentar los avances en sus proyectos. En la reunión han estado presentes los componentes del comité evaluador de las ayudas: Laura Halpern Serra, vicepresidenta de Fundación Jesús Serra, y los investigadores del CNB Inés M. Antón, Lluís Montoliu (vicedirector) y Mario Mellado, director del centro, así como Susana Codina, subdirectora de Fundación Jesús Serra y Ana Cuenda, vicedirectora del CNB.
A lo largo de la jornada, los grupos han detallado los avances realizados gracias al apoyo de la Fundación, que les han permitido desde realizar la puesta a punto de modelos celulares o la modernización de equipos necesarios en su investigación hasta publicar en revistas de prestigio internacional.
CNB participates in DeCYPher, a new european project that combines AI to obtain natural compounds
La regulación de la forma celular abre nuevas vías terapéuticas frente a Salmonella
- Un nuevo mecanismo de regulación de la morfogénesis celular podría servir como diana efectiva para el tratamiento de las infecciones persistentes intracelulares causadas por Salmonella
Investigadores del Consejo Superior de Investigaciones Científicas (CSIC) en el Centro Nacional de Biotecnología (CNB-CSIC) han identificado un nuevo mecanismo molecular implicado en morfogénesis bacteriana que podría servir como diana efectiva para el tratamiento de las infecciones persistentes intracelulares por Salmonella. Los resultados de este trabajo se publican en la revista Communications Biology.
Pablo Laborda recibe el Premio Margarita Salas Ciencias de la Vida a las mejores tesis doctorales realizadas en la Comunidad de Madrid
- El investigador Pablo Laborda ha recibido uno de los Premios Margarita Salas de Investigación por su tesis doctoral, el reconocimiento del Ayuntamiento de Madrid a las mejores tesis doctorales defendidas en la comunidad de Madrid. Su trabajo ha recibido el segundo premio en la categoría Ciencias de la Vida.
Laborda realizó su tesis doctoral “Understanding evolution to tackle antibiotic resistance in Pseudomonas aeruginosa” en el CNB-CSIC bajo la supervisión de los investigadores Sara Hernando y José Luis Martínez. Además de recibir la máxima calificación (Sobresaliente Cum laude y mención internacional) por su tesis, los resultados de su tesis han dado lugar a la publicación de 17 artículos en revistas internacionales revisadas por pares, incluyendo 7 primeras autorías, y artículos en revistas de alto impacto como PNAS, Molecular Biology and Evolution, Nature Communications o Nature Reviews in Microbiology.
A legacy from Ms. María Lourdes Díaz de la Guardia will fund a cancer research project at the CNB-CSIC.
De plegar a proteger: identificados los cambios estructurales de la chaperona DNAJA2 que le permiten cambiar su función celular
Investigadores del Centro Nacional de Biotecnología del Consejo Superior de Investigaciones Científicas (CNB-CSIC) y la Universidad del País Vasco han colaborado en el descubrimiento del mecanismo de funcionamiento de la chaperona DNAJA2, perteneciente a la familia de las llamadas Hsp40 o proteínas J, el más diverso dentro de las chaperonas. El trabajo, publicado en Nature Communications, desvela cómo las diferentes condiciones celulares afectan a su función.
Las chaperonas moleculares son un variado grupo de proteínas involucradas en la síntesis, plegamiento, prevención de la formación de agregados y degradación de las proteínas celulares. Debido a ese papel tan crítico en el control de la calidad de las proteínas, los errores en su funcionamiento están asociados a procesos cancerígenos y a distintas enfermedades degenerativas. Muchas de estas chaperonas pueden funcionar como moléculas individuales (monómeros), o en conjunto, desde dímeros a estructuras oligoméricas, y algunas varían su estado dependiendo de las circunstancias. Este trabajo muestra que la chaperona DNAJA2, de la familia Hsp40 (hasta ahora conocidas como auxiliares de las chaperonas Hsp70, pero cuyo papel se está mostrando cada día más importante), es una de las que puede actuar tanto como monómero como oligómero.
Luis Enjuanes receives the Gregorio Marañon National Research Award
The National Research Awards 2023, granted by the Ministry of Science and Innovation, recognise the professional career of CNB researcher Luis Enjuanes. The jury has awarded him the 'Gregorio Marañón' National Research Award, in the area of Medicine and Health Sciences, for the excellence and impact of his work, making him a reference in the field of virology. His excellent career is complemented by the impact of his contributions to the knowledge of coronavirus replication and transcription, as well as his continuous research and innovation in the area of vaccines.
The National Research Awards, worth 30,000 euros in each category, distinguish Spanish researchers who stand out for their careers and international relevance in their respective areas of research. They also recognise the merit of young people - with a maximum age of 40 - who have made significant achievements in the early stages of their careers.
In addition to the CNB researcher, the awards have recognised the work of seven other researchers from the Spanish National Research Council (CSIC) in the fields of archaeology, virology, mathematics and global change, as well as molecular biology, nanogenerators and dance.
First Cryo-EM structures of homomeric GluA1 AMPA glutamate receptor reveals functional roles for N-terminal domains
Previously unseen structural flexibility of N-terminal domains is crucial for regulating speed by which GluA1 opens and closes ion channel gate, and recruiting receptor into synapse
AMPA receptors (AMPARs) are glutamate-gated cation channels, composed of four core subunits – GluA1 to GluA4 – and are the primary mediators of excitatory neurotransmission throughout the brain, playing a central role in learning and memory at synapses. There are two primary types of receptors: GluA2-containing, Ca2+- impermeable, and GluA2-lacking, Ca2+-permeable (CP). All structural studies have focused on the former, which dominate in the brain. There is currently no structural knowledge concerning GluA2-lacking receptors, despite their prominent expression in glia and interneurons, and their involvement in long-term potentiation and a range of neuropathologies. Ingo Greger’s group, in the LMB’s Neurobiology Division, has now published the first structures of a GluA2-lacking AMPAR, the GluA1 AMPA receptor homomer, a prominent CP AMPAR.
A new mathematical model explains the relationship between cognitive complexity and brain asymmetry
- The framework, developed by a scientist at the Spanish National Research Council (CSIC), allows us to carry out calculations concerning neural circuits and the presence of symmetries, and to test empirical hypotheses
- The new theory proves mathematically an open conjecture dating back to the beginnings of neuroscience.
Most animals have mirror-symmetric bodies: left and right are equal, but flipped side-wise. This property is inherited by the brain. However, some cognitive functions break this symmetry and appear lateralized. For example, language usually engages only the left side. The biological mechanisms for breaking this symmetry are not known in detail. A new mathematical framework developed by Luis F Seoane, researcher at the Spanish National Research Council (CSIC), proves how the emergence of higher cognitive complexity entails an evolutionary pressure that favors brain lateralization. The scientific paper verifying this popular hypothesis is published by the journal Physical Review X.
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