RESEARCH SUMMARY

Our group is interested in the molecular and cellular mechanisms allowing the formation of the immunological synapses.

To become activated, T-cells must establish cell–cell contact with antigen-presenting cells (APCs). This contact, known as the immune synapse (IS), drives major morphological and functional changes in T-cells, including massive actin rearrangements necessary for productive IS formation. IS serves as a platform for large-scale molecular exchange between the IS forming cells. Multiple cytokines and vesicles, which drive intercellular communication, are released to the synaptic cleft.

We showed for the first time that clathrin is essential for the massive actin polymerization observed at the IS. This finding, observed in cell lines and primary cells, is of outstanding relevance not only to Immunologist but also to Cellular Biologists, and scientists in the field of Cellular Microbiology.

Currently, we are also carry on studies on the molecular mechanisms driving pathogen infections and extending these studies to the intimate relation between bacterial and fungal pathogens with the cells of the immune system. We are also exploring the possible therapeutic use of bacterial products able to modify the immunological system.