Category
Seminarios
- Seminario de Ciclo Junior
Date
Friday, 31 January 2014 12:00
Venue
Salón de Actos del CNB - Calle Darwin, 3, 28049 Madrid
Madrid, España
COM_ICAGENDA_PONENTE
Dr. David Rueda . Imperial College, London, UK
COM_ICAGENDA_CONTACTO
María Eugenia Fuentes
COM_ICAGENDA_NOTES
The activation-induced deoxycytidine deaminase (AID) is a member the Apobec family of enzymes that catalyzes C to U deamination on ssDNA tri-nucleotide motifs. In B cells, it is required to generate antibody diversity by initiating somatic hypermutation (SHM) in the variable region of immunoglobulin genes and class-switch recombination (CSR) in immunoglobulin switch regions. In turn, SHM and CSR are required to generate high-affinity antibodies that bind and neutralize invading antigens. Thus, AID plays an indispensable role in causing mutational diversity to enhance fitness and optimize the immune response.