Dimitrios Balomenos

INTERPLAY OF ACTIVATION, APOPTOSIS AND CELL CYCLE REGULATORS MONITORS AUTOIMMUNE T CELL MEMORY RESPONSES AND INFLAMMATION

Apoptosis is considered a basic mechanism for limiting T cell memory expansion known as homeostasis. Nevertheless, we find that the control of activation of memory T cells and of proliferation are also fundamental for memory T cell homeostasis. We suggest that memory responses and homeostasis require a combination of control in activation, apoptosis and proliferation.The cell cycle inhibitor p21 suppreses autoimmunity and controls T cell memory responses.