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Viral genome packaging by the ring-shaped small terminase. In collaboration with CNB researcher Juan Carlos Alonso, Alfred Antson at the University of York has determined for the first time that although the small terminase is ring-shaped, the central region is not wide enough to accommodate the DNA inside. Recently published in PNAS, the small terminase crystal structure reveals that DNA wraps around the terminase complex by binding to an external motif present in each of the nine oligomers of the terminase.

MEMTRONICS: electronic circuits with memory, learning and adaptation. CNB researcher Francisco J. Iborra participates in the organisation of the First Sax meeting on MEMTRONICS. This is an emerging technology whose function is being exploited in the novel circuits we are trying to use to model complex systems with memory, such us biological systems.

The X-ray structure of the HRV2 empty capsid. Upon attachment to their respective receptor, human rhinoviruses (HRVs) are internalized into the host cell via different pathways but undergo similar structural changes. The structural comparison between native and empty HRV2 particles unveils a number of pH-sensitive amino acid residues, conserved in rhinoviruses, which participate in the structural rearrangements involved in the uncoating process.

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