Departamento de Biología Molecular y Celular
Department of Molecular and Cellular Biology
CNB-CSIC

Lab. Prof. José Ramón Naranjo

Tel. +34 915854682 (office) / Tel. +34 915854913 (lab.)
Fax. +34 915854506

 Laboratory WEB page



Objetivos / Aims

El estudio de la proteina DREAM (modulador antagonista de sitios DRE), un represor transcripcional regulado por calcio.
The study of the DREAM protein (DRE antagonist modulator), a transcriptional repressor regulated by calcium.

Memoria Científica 2003-2004

Research Summary 2003-2004


Personal / Staff

José Ramon Naranjo
Maria Rosa Gómez Villafuertes
Paz González Pérez
David Campos López
Jorge Rubén Cabrera Heredia
Britt Mellstrom
Jorge Barrio Burgos
Magali Savignac
Malgosia Palczewska
Marcos Rivas González
Tomaso Benedet
Laura Fabricci
Dmitri Lim
Estrella López
Sofia Domingo


Publicaciones recientes / Recent Publications:

Rosa Gomez-Villafuertes, Jorge Barrio1, Begoña Torres1, Nadia Gabellini, Magali Savignac, Federico Rizzato, Belen Pintado, Alfonso Gutierrez-Adan, Britt Mellström, Ernesto Carafoli, Jose R. Naranjo
The down regulation of the Na+/Ca2+ exchanger 3 by Ca2+-insensitive DREAM mutants regulates neuronal viability.
J. Neurosci. 25(47):10822-30.

Savignac M, Pintado B, Gutierrez-Adan A, Palczewska M, Mellstrom B, Naranjo JR.
Transcriptional repressor DREAM regulates T-lymphocyte proliferation and cytokine gene expression.
EMBO J. 2005 Oct 19;24(20):3555-64. Epub 2005 Sep 22.

Scsucova S, Palacios D, Savignac M, Mellstrom B, Naranjo JR, Aranda A.
The repressor DREAM acts as a transcriptional activator on Vitamin D and retinoic acid response elements.
Nucleic Acids Res. 2005 Apr 22;33(7):2269-79.

Mellstrom B, Torres B, Link WA, Naranjo JR.
The BDNF gene: exemplifying complexity in Ca2+ -dependent gene expression.
Crit Rev Neurobiol. 2004;16(1-2):43-9.

Link WA, Ledo F, Torres B, Palczewska M, Madsen TM, Savignac M, Albar JP, Mellstrom B, Naranjo JR. (2004)
Day-night changes in downstream regulatory element antagonist modulator/potassium channel interacting protein activity contribute to circadian gene expression in pineal gland.
Journal of Neuroscience 24(23):5346-5355.

Rivas M, Mellstrom B, Naranjo JR, Santisteban P.(2004)
Transcriptional repressor DREAM interacts with thyroid transcription factor-1 and regulates thyroglobulin gene expression.
Journal of Biological Chemistry  279(32):33114-33122. Epub 2004 Jun 04.

Zamorano A, Mellstrom B, Vergara P, Naranjo JR, Segovia J. (2004)
Glial-specific retrovirally mediated gas1 gene expression induces glioma cell apoptosis and inhibits tumor growth in vivo.
Neurobiology of Disease 15(3):483-491.

Klattenhoff C, Montecino M, Soto X, Guzman L, Romo X, Garcia MA, Mellstrom B, Naranjo JR, Hinrichs MV, Olate J. (2003)
Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol.
Journal of Cellular Physiology 195(2):151-157.

Zamorano A, Lamas M, Vergara P, Naranjo JR, Segovia J. (2003)
Transcriptionally mediated gene targeting of gas1 to glioma cells elicits growth arrest and apoptosis.
Journal of Neuroscience Research 71(2):256-263.



Last update: 14 February 2006
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