Lab. Prof. José Ramón Naranjo
Tel. +34 915854682 (office) / Tel. +34 915854913
(lab.)
Fax. +34 915854506
El estudio de la proteina DREAM (modulador antagonista
de sitios DRE), un represor transcripcional regulado por calcio.
The study of the DREAM protein
(DRE antagonist modulator), a transcriptional repressor regulated by calcium.
José
Ramon Naranjo
Maria Rosa
Gómez Villafuertes
Paz González
Pérez
David Campos
López
Jorge Rubén
Cabrera Heredia
Britt Mellstrom
Jorge Barrio
Burgos
Magali Savignac
Malgosia
Palczewska
Marcos Rivas
González
Tomaso Benedet
Laura Fabricci
Dmitri Lim
Estrella
López
Sofia Domingo
Publicaciones recientes / Recent Publications:
Rosa Gomez-Villafuertes, Jorge Barrio1, Begoña
Torres1, Nadia Gabellini, Magali Savignac, Federico Rizzato, Belen Pintado,
Alfonso Gutierrez-Adan, Britt Mellström, Ernesto Carafoli, Jose R.
Naranjo
The
down regulation of the Na+/Ca2+ exchanger 3 by Ca2+-insensitive DREAM mutants
regulates neuronal viability.
J. Neurosci. 25(47):10822-30.
Savignac M, Pintado B, Gutierrez-Adan A, Palczewska
M, Mellstrom B, Naranjo JR.
Transcriptional
repressor DREAM regulates T-lymphocyte proliferation and cytokine gene
expression.
EMBO J. 2005 Oct 19;24(20):3555-64. Epub 2005 Sep
22.
Scsucova S, Palacios D, Savignac M, Mellstrom B,
Naranjo JR, Aranda A.
The
repressor DREAM acts as a transcriptional activator on Vitamin D and retinoic
acid response elements.
Nucleic Acids Res. 2005 Apr 22;33(7):2269-79.
Mellstrom B, Torres B, Link WA, Naranjo JR.
The
BDNF gene: exemplifying complexity in Ca2+ -dependent gene expression.
Crit Rev Neurobiol. 2004;16(1-2):43-9.
Link WA, Ledo F, Torres B, Palczewska M, Madsen
TM, Savignac M, Albar JP, Mellstrom B, Naranjo JR. (2004)
Day-night
changes in downstream regulatory element antagonist modulator/potassium
channel interacting protein activity contribute to circadian gene expression
in pineal gland.
Journal of Neuroscience 24(23):5346-5355.
Rivas M, Mellstrom B, Naranjo JR, Santisteban P.(2004)
Transcriptional
repressor DREAM interacts with thyroid transcription factor-1 and regulates
thyroglobulin gene expression.
Journal of Biological Chemistry 279(32):33114-33122.
Epub 2004 Jun 04.
Zamorano A, Mellstrom B, Vergara P, Naranjo JR,
Segovia J. (2004)
Glial-specific
retrovirally mediated gas1 gene expression induces glioma cell apoptosis
and inhibits tumor growth in vivo.
Neurobiology of Disease 15(3):483-491.
Klattenhoff C, Montecino M, Soto X, Guzman L, Romo
X, Garcia MA, Mellstrom B, Naranjo JR, Hinrichs MV, Olate J. (2003)
Human
brain synembryn interacts with Gsalpha and Gqalpha and is translocated
to the plasma membrane in response to isoproterenol and carbachol.
Journal of Cellular Physiology 195(2):151-157.
Zamorano A, Lamas M, Vergara P, Naranjo JR, Segovia
J. (2003)
Transcriptionally
mediated gene targeting of gas1 to glioma cells elicits growth arrest and
apoptosis.
Journal of Neuroscience Research 71(2):256-263.