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Mutagenesis drive diversification and persistence of Pseudomonas aeruginosa. Pseudomonas aeruginosa is a versatile opportunistic pathogen
causing a wide variety of hospital-acquired acute infections in
immunocompromised patients
as well as chronic respiratory infections in
patients suffering from cystic fibrosis or other chronic respiratory
diseases.
Workshop on the study of Hepatitis C virus infection. Organized by CNB researcher Pablo Gastaminza, on 13 April 2012 we are hosting a workshop on the study of hepatitis C virus infection at the Centro Nacional de Biotecnología.
ATP hydrolysis drives microcantilever bending. The collaboration between José L. Carrascosa a and Javier Tamayo at the Instituto de Microelectrónica de Madrid has given rise to a novel measurement of real time conformational changes of viral ATPases. The researchers showed that the nanomechanical response of its device was dependent on the monolayer arrangement of ATPases at the cantilever surface.
XIX CNB Scientific Workshop. On December 19th and 20th, we will host our XIX Scientific Workshop, an excellent opportunity for an update in the Life Sciences research carried out at the Centro Nacional de Biotecnología.
CNB in the Media
Nature Medicine. Spain reeling from budget and staff cuts in biomedicine
Radiosíntesis. Salud Biotec nº 2
Público. El primer virus creado y censurado por el hombre
La Nueva España. «Al ser concebidos heredamos una marca genética, pero el embarazo viene con más instrucciones»
El Mundo. Nuevas herramientas para la 'nanobioingeniería'
Diario Médico. Dos décadas de ciencia contemplan al CNB
El Mundo. La fuerza de la luz para estirar una sola molécula
Radiosíntesis. Salud Biotec nº 1
El País. Explosiones en miniatura para un desafío biológico
El País. El Programa de Excelencia Severo Ochoa: Luces y Sombras
The Telegraph. Vaccine could reduce HIV to 'minor infection'
Nature Reviews. Direct injection of functional single-domain antibodies from E. coli into human cells
Microbe. Microbiology goes digital
GEN. Crescendo Claims Triple Knockout Mice Lack IgH and Kappa/Lambda Light Chains
Scientific Publications
PLoS PATHOGENS. Insights into minor group rhinovirus uncoating: the X-ray structure of the HRV2 empty capsid
Acta Crystallogr Sect F Struct Biol Cryst Commun. Crystallization of the C-terminal domain of the bacteriophage T7 fibre protein gp17
PLoS ONE. The ζ Toxin Induces a Set of Protective Responses and Dormancy
BMC Bioinformatics. Estimation of bacterial diversity using next generation sequencing of 16S rDNA: a comparison of different workflows
Journal of Molecular Medicine. Aberrant epigenetic regulation of bromodomain Brd4 in human colon cancer
Nucleis Acids Research. A promoter DNA demethylation landscape of human hematopoietic differentiation
Nature Reviews Genetics. Epigenetics and the environment: emerging patterns and implications
Nature. Control of flowering and storage organ formation in potato by FLOWERING LOCUS T
Science & Society
Alfonso M. Corral. Cómo las bacterias se hacen resistentes a los antibióticos
Miguel Vicente. Polio, ¿otro virus expulsado al zoológico?
Miguel Vicente. Las pandemias viajaban en galeón.
Meet our Scientists
The main objectives of our laboratory are geared toward understanding the molecular basis of the pathogenesis of infectious agents and their interaction with the host, as well as to use this knowledge in the development of vaccines that might be effective against diseases like AIDS, malaria and leishmaniasis. As a model system of an infectious agent and as a delivery vector for expression of genes of interest, we used vaccinia virus (VV), a member of the poxvirus family. |
Mariano Esteban