The shikimic acid pathway is essential to many pathogens but absent in mammals. Enzymes in its pathway are therefore appropriate targets for the development of novel antibiotics.

publications
- González-Bello C, Tizón L, Lence E, Otero JM, van Raaij MJ, Martinez-Guitian M, Beceiro A, Thompson P, Hawkins AR (2015) Chemical Modification of a Dehydratase Enzyme Involved in Bacterial Virulence by an Ammonium Derivative: Evidence of its Active Site Covalent Adduct. J Am Chem Soc 137, 9333-9343.
- Tizon L, Maneiro M, Peon A, Otero JM, Lence E, Poza S, van Raaij MJ, Thompson P, Hawkins AR, Gonzalez-Bello C (2015) Irreversible covalent modification of type I dehydroquinase by a stable Schiff base. Org Biomol Chem 13, 706-716.
- Maneiro M, Peon A, Lence E, Otero JM, van Raaij MJ, Thompson P, Hawkins AR, Gonzalez-Bello C (2014) Insights into Substrate Binding and Catalysis in Bacterial Type I Dehydroquinase. Biochem J 462, 415-426.
- Blanco B, Sedes A, Peon A, Otero JM, van Raaij MJ, Thompson P, Hawkins AR, Gonzalez-Bello C (2014) Exploring the Water-Binding Pocket of the Type II Dehydroquinase Enzyme in the Structure-Based Design of Inhibitors. J Med Chem 57, 3494-3510.
- Blanco B, Prado V, Lence E, Otero JM, Garcia-Doval C, van Raaij MJ, Llamas-Saiz AL, Lamb H, Hawkins AR, González-Bello C (2013) Mycobacterium tuberculosis Shikimate Kinase Inhibitors: Design and Simulation Studies of the Catalytic Turnover. J Am Chem Soc 135, 12366-12376.
- Lence E, Tizón L, Otero JM, Peón A, Prazeres VF, Llamas-Saiz AL, Fox GC, van Raaij MJ, Lamb H, Hawkins AR, González-Bello C (2013) Mechanistic Basis of the Inhibition of Type II Dehydroquinase by (2S)- and (2R)-2-Benzyl-3-dehydroquinic Acids. ACS Chem Biol 8, 568-577
- Tizon L, Otero JM, Prazeres VF, Llamas-Saiz AL, Fox GC, van Raaij MJ, Lamb H, Hawkins AR, Ainsa JA, Castedo L, Gonzalez-Bello C (2011) A Produg Approach for Improving Antituberculosis Activity of Potent Mycobacterium tuberculosis Type II Dehydroquinase Inhibitors. J Med Chem 54, 6063-6084
- Paz S, Tizon L, Otero JM, Llamas-Saiz AL, Fox GC, van Raaij MJ, Lamb H, Hawkins AR, Castedo L, Gonzalez-Bello C (2011) Synthesis of tetrahydrobenzothiophene derivatives, inhibitors of an essential enzyme in Helicobacter pylori survival, by intramolecular condensation of stable ozonide with Lawesson's reagent. ChemMedChem 6, 266-272
- Peon A, Otero JM, Tizon L, Prazeres VF, Llamas-Saiz AL, Fox GC, van Raaij MJ, Lamb H, Hawkins AR, Gago F, Castedo L, Gonzalez-Bello C (2010) Understanding the key factors that control the inhibition of type 2 dehydroquinase by (2R)-2-benzyl-3- dehydroquinic acids. ChemMedChem 4, 1726-1733
- Prazeres VF, Tizon L, Otero JM, Guardado-Calvo P, Llamas-Saiz AL, van Raaij MJ, Castedo L, Lamb H, Hawkins AR, Gonzalez-Bello C (2010) Synthesis and Biological Evaluation of New Nanomolar Competitive Inhibitors of Helicobacter pylori Type II Dehydroquinase. Structural Details of the Role of the Aromatic Moieties with Essential Residues. J Med Chem 53, 191-200

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